Reactive hydroxyl radical-driven oral bacterial inactivation by radio frequency atmospheric plasma

Kang, Seong-Hoon; Choi, Moon‐Hee; Koo, Il Gyo; Kim, Paul Y.; Kim, Yoonsun; Kim, Gon Jun; Mohamed, Abdel‐Aleam H.; Collins, G. J.; Lee, Jae Koo

doi:10.1063/1.3574639

Cited by 45 publications

(29 citation statements)

References 8 publications

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“…OH radicals may be quenched when plasma passes through saline and YPD solutions, eventually leading to less cell damage in saline and YPD. The toxic effects of OH radicals in plasma have already been observed in other studies [33]–[34]. OH radicals seems to be involved in membrane lipid peroxidation.…”

Section: Discussionsupporting

confidence: 54%

Effects of Background Fluid on the Efficiency of Inactivating Yeast with Non-Thermal Atmospheric Pressure Plasma

et al. 2013

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Non-thermal plasma at atmospheric pressure has been actively applied to sterilization. However, its efficiency for inactivating microorganisms often varies depending on microbial species and environments surrounding the microorganisms. We investigated the influence of environmental factors (surrounding media) on the efficiency of microbial inactivation by plasma using an eukaryotic model microbe, Saccharomyces cerevisiae, to elucidate the mechanisms for differential efficiency of sterilization by plasma. Yeast cells treated with plasma in water showed the most severe damage in viability and cell morphology as well as damage to membrane lipids, and genomic DNA. Cells in saline were less damaged compared to those in water, and those in YPD (Yeast extract, Peptone, Dextrose) were least impaired. HOG1 mitogen activated protein kinase was activated in cells exposed to plasma in water and saline. Inactivation of yeast cells in water and saline was due to the acidification of the solutions by plasma, but higher survival of yeast cells treated in saline may have resulted from the additional effect related to salt strength. Levels of hydroxyl radical (OH.) produced by plasma were the highest in water and the lowest in YPD. This may have resulted in differential inactivation of yeast cells in water, saline, and YPD by plasma. Taken together, our data suggest that the surrounding media (environment) can crucially affect the outcomes of yeast cell plasma treatment because plasma modulates vital properties of media, and the toxic nature of plasma can also be altered by the surrounding media.

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Section: Discussionsupporting

confidence: 54%

Effects of Background Fluid on the Efficiency of Inactivating Yeast with Non-Thermal Atmospheric Pressure Plasma

et al. 2013

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“…They observed a significant increase in a dose dependent manner in the inactivation of P. gingivalis in the treatment group compared with control. Kang et al used RF atmospheric plasma to inactivate Streptococcus mutans [100]. The gas used was a mix of Argon and Hydrogen Peroxide.…”

Section: Methods Of Productionmentioning

confidence: 99%

Cold Atmospheric Plasma: methods of production and application in dentistry and oncology

Hoffmann

Berganza

Zhang

2013

Medical Gas Research

288

185

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Cold Atmospheric Plasma is an ionized gas that has recently been extensively studied by researchers as a possible therapy in dentistry and oncology. Several different gases can be used to produce Cold Atmospheric Plasma such as Helium, Argon, Nitrogen, Heliox, and air. There are many methods of production by which cold atmospheric plasma is created. Each unique method can be used in different biomedical areas. In dentistry, researchers have mostly investigated the antimicrobial effects produced by plasma as a means to remove dental biofilms and eradicate oral pathogens. It has been shown that reactive oxidative species, charged particles, and UV photons play the main role. Cold Atmospheric Plasma has also found a minor, but important role in tooth whitening and composite restoration. Furthermore, it has been demonstrated that Cold Atmospheric Plasma induces apoptosis, necrosis, cell detachment, and senescence by disrupting the S phase of cell replication in tumor cells. This unique finding opens up its potential therapy in oncology.

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“…Non‐equilibrium atmospheric pressure plasma jets (APPJs) have been attractive for many biomedical applications, ranging from cancer cell treatment, sterilization, wound healing, coagulation, and tooth whitening . Compared with the low‐pressure plasmas, APPJs have advantages because they can be operated without a bulky vacuum pump with relatively low power requirements .…”

Section: Introductionmentioning

confidence: 99%

Characterization and Effects of Ar/Air Microwave Plasma on Wound Healing

Kim

Kang

Park

et al. 2015

Plasma Processes & Polymers

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1Using Ar/Air mixture microwave plasma, we investigated the effects of air and gas temperature on the generation of electrons, ozone (O 3 ), and nitric oxide (NO) through experiments and chemical kinetics simulation. The global model (GM) chemical kinetics simulation was used to validate and complement experimental observations. As the air percentages in Ar plasma increase, electrons are mainly generated by reactive oxygen species (ROS), but electron densities decrease. This is why plasma jet length becomes shorter with the mixture of air to Ar plasma at the same power. The profile of O 3 densities has a maximum point because these are affected by oxygen (O 2 ) molecules and gas temperature. O 3 densities increase because these are generated via recombination of atomic oxygen (O) and O 2 radicals as the air percentages increase. As the gas temperature increases, O 3 densities decrease and O 3 radicals are mainly destroyed by ROS such as O 2 À , excited O 2 , and O, although air percentages increase. NO radicals increase continually with the addition of air mixture and increase in gas temperature. With respect to biomedical applications, in the case of Ar/Air plasma treatment, it takes just 2 d, which has reduced the wound area to 30% because of faster scab formation over the wound and mRNA activation. Abundant NO radicals with ROS in Ar/aAir plasma strongly enhance IL-6 and TGF-b1, which facilitate collagen remodeling and wound recovery effectively.

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Reactive hydroxyl radical-driven oral bacterial inactivation by radio frequency atmospheric plasma

Cited by 45 publications

References 8 publications

Effects of Background Fluid on the Efficiency of Inactivating Yeast with Non-Thermal Atmospheric Pressure Plasma

Effects of Background Fluid on the Efficiency of Inactivating Yeast with Non-Thermal Atmospheric Pressure Plasma

Cold Atmospheric Plasma: methods of production and application in dentistry and oncology

Characterization and Effects of Ar/Air Microwave Plasma on Wound Healing

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