Reactive crystallization: From mixing to control of kinetics by additives

Teychené, Sébastien; Rodríguez-Ruiz, Isaac; Ramamoorthy, Raj Kumar

doi:10.1016/j.cocis.2020.01.003

Cited by 30 publications

(19 citation statements)

References 132 publications

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“…However, composition changes over time have been mostly restricted, due to the use of batch methods, to a time range from seconds to hours. Since nucleation, the onset of nanoparticles formation, usually occurs in much shorter times [6,7], it thus proceeds at constant composition in most syntheses. Controlling composition changes over sub-second time ranges would thus allow exploring an uncharted, but pivotal, area of the parameter space.…”

Section: Introductionmentioning

confidence: 99%

Controlling nanoparticle formation from the onset of nucleation through a multi-step continuous flow approach

Roger

Amri

2022

Journal of Colloid and Interface Science

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Section: Introductionmentioning

confidence: 99%

Controlling nanoparticle formation from the onset of nucleation through a multi-step continuous flow approach

Roger

Amri

2022

Journal of Colloid and Interface Science

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“…Most processes reviewed are governed by micromixing. Detection of the influence of mesomixing for the BIS system provides valuable insights into the underlying process with implications for scale-up. ,, Identifying the point of influence as the conversion of oligomers to primary/secondary particles indicates that this step occurs on time scales similar to mixing timescales. Consequently, the associated nucleation/aggregation processes are sensitive to this regime.…”

Section: Production Capabilitymentioning

confidence: 99%

Recent Advances in Enabling Green Manufacture of Functional Nanomaterials: A Case Study of Bioinspired Silica

Pilling

Patwardhan

2022

ACS Sustainable Chem. Eng.

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Global specialty silica production is over 3 million tonnes per annum with diverse applications across sectors and an increasing demand for more complex material structures and surface chemistries. Commercial manufacturing of high-value silica nanomaterials is energy and resource intensive. In order to meet market needs and mitigate environmental impacts, new synthesis methods for these porous materials are required. The development of the bioinspired silica (BIS) product system, which is the focus of this review, provides a potential solution to this challenge. BIS is a versatile and greener route with the prospect of good scalability, attractive process economics and well controlled product materials. The potential of the system lies not only in its provision of specific lead materials but also, as itself, a rich design-space for the flexible and potentially predictive design of diverse sustainable silica nanomaterials. Realizing the potential of this design space, requires an integrative mind-set, which enables parallel and responsive progression of multiple and dependent research strands, according to need, opportunities, and emergent knowledge. Specifically, this requires development of detailed understanding of (i) the pathways and extent of material diversity and control, (ii) the influences and mechanisms of scale-up, and (iii) performance, economic and environmental characteristics and sensitivities. Crucially, these need to be developed for the system overall, which sits in contrast to a more traditional research approach, which focuses initially on the discovery of specific material leads at the laboratory scale, leaving scale-up, commercialization, and, potentially, pathway understanding to be considered as distinctly separate concerns. The intention of this review is to present important recent advances made in the field of BIS. Specifically, advances made along three research themes will be discussed: (a) particle formation pathways, (b) product design, and (c) scale-up and manufacture. These advances include first quantitative investigation of synthesis-product relationships, first structured investigation of mixing effects, preparation of a broad range of functionalized and encapsulated silica materials and continued industrial engagement and market research. We identify future challenges and provide an important foundation for the development of new research avenues. These include the need to develop comprehensive and predictive product design models, to understand markets in terms of product cost, performance and environmental considerations, and to develop capabilities enabling rapid prototyping and scale-up of desired nanomaterials.

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“…In addition, microwave-assisted evaporation crystallization resulted in significantly narrower standard deviation in the crystal size. For crystallization involving a reaction or antisolvent, mixing of the feed streams can greatly affect the crystallization process and hence the critical quality attributes such as particle size distribution. , Additionally, concentration control has been reported in cooling and antisolvent crystallization. − The adaptive control started cooling until primary nucleation occurred, then adapted to maintain the desired counts/s based on FBRM, able to detect the new metastable zone width which changes with the amount of solids in the slurry, providing fine particle removal with no additional equipment or design needed. The resulting temperature profile showed bursts of increased temperature dissolving excess crystals …”

Section: Key Process Parameters To Obtain Large Particle Sizesmentioning

confidence: 99%

Targeting Particle Size Specification in Pharmaceutical Crystallization: A Review on Recent Process Design and Development Strategies and Particle Size Measurements

Liu

Bagi²,

Su³

et al. 2022

Org. Process Res. Dev.

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Obtaining a particle size within the specifications for a pharmaceutical compound in an industrial crystallization can be a challenging task. The events affecting the final particle size of the product include nucleation, growth, breakage, and agglomeration, which are often convoluted. Secondary nucleation may significantly influence the particle size distribution. The strategies and techniques relevant to obtaining an in-spec particle size in crystallization are summarized and discussed from a perspective of process parameters. The effect of cooling profiles, seeding strategies, as well as mixing by agitation are reviewed, and an efficient and controlled crystallization process may be achieved using an optimized combination of these conditions. Multiple characterization methods for particle size and distribution are compared, and the discrepancies associated with the measurements are addressed.

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Reactive crystallization: From mixing to control of kinetics by additives

Cited by 30 publications

References 132 publications

Controlling nanoparticle formation from the onset of nucleation through a multi-step continuous flow approach

Controlling nanoparticle formation from the onset of nucleation through a multi-step continuous flow approach

Recent Advances in Enabling Green Manufacture of Functional Nanomaterials: A Case Study of Bioinspired Silica

Targeting Particle Size Specification in Pharmaceutical Crystallization: A Review on Recent Process Design and Development Strategies and Particle Size Measurements

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