Controlling nanoparticle formation from the onset of nucleation through a multi-step continuous flow approach

Roger, Kévin; Amri, Nouha El

doi:10.1016/j.jcis.2021.10.071

Cited by 9 publications

(9 citation statements)

References 37 publications

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“…The synthesis was performed in the presence of high concentrations of acetic acid to obtain silver nanoplates. 15 Figure 1 C shows that this synthesis yielded a red-purple liquid that displays three plasmonic bands characteristic of silver nanoplates, 17 as confirmed by TEM imaging. Over time, color changes were observed until a yellow tint was obtained corresponding to a single absorption peak, which is characteristic of isotropic particles.…”

Section: ■ Introductionmentioning

confidence: 72%

“…Nanoparticles were synthesized using a continuous flow setup that associates three rapid mixing units . Each unit consists of four inlets meeting tangentially in a mixing chamber and exiting orthogonally, as first described by Hartridge and Roughton .…”

Section: Methodsmentioning

confidence: 99%

“…Nanoparticles were synthesized using a continuous flow setup that associates three rapid mixing units. 15 Each unit consists of four inlets meeting tangentially in a mixing chamber and exiting orthogonally, as first described by Hartridge and Roughton. 23 In the first mixer, the first inlet was used for the injection of a 2.2 mM silver nitrate aqueous solution, the second inlet was used for the injection of a 1.57 M aqueous solution of acetic acid, and the other two inlets were connected with a Tjunction in which a 2.3 mM purified PVP aqueous solution is added.…”

Section: ■ Conclusionmentioning

confidence: 99%

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An Alkanethiol-Surfactant Bilayer To Prevent Shape Conversion of Anisotropic Silver Nanoparticles and Probe Their Formation Mechanisms

Amri

Roger

2023

Langmuir

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Anisotropic nanoparticles can be synthesized under kinetic control but may undergo subsequent shape changes due to atomic reorganization. Furthermore, their synthesis involves rapid steps, which are challenging to monitor in situ. Here, we show how a nanoemulsion of alkanethiols with an ethoxylated surfactant, easily prepared and metastable for months, can simultaneously prevent shape reorganization and arrest reaction kinetics. We illustrate this generic method on the silver nanoplates synthesized in concentrated acetic acid aqueous solutions, in which rapid shape reorganization occurs. We show that there exists an optimum thiol concentration corresponding to full coverage of all silver surface atoms, which can be simply calculated from particle dimensions. Furthermore, we demonstrate that arresting nanoparticle formation can be achieved within milliseconds using a tandem rapid mixers scheme in a continuous flow setup, allowing ex situ monitoring of the reaction.

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Section: ■ Introductionmentioning

confidence: 72%

Section: Methodsmentioning

confidence: 99%

Section: ■ Conclusionmentioning

confidence: 99%

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An Alkanethiol-Surfactant Bilayer To Prevent Shape Conversion of Anisotropic Silver Nanoparticles and Probe Their Formation Mechanisms

Amri

Roger

2023

Langmuir

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“…It is only by inspecting time‐resolved data during synthesis, revealing the different mechanistic stages taking place, and measuring their relative rates, that one can design the synthesis of size‐controlled nanomaterials to move away from trial‐and‐error. However, this objective is particularly complex due to the fast nature of the reactions: for example, coprecipitation of lead‐halide perovskite nanocrystals is known to take place within ms, [ 344 ] similar to the nucleation stage of some plasmonic nanoparticles (e.g., Au). [ 25 ] Traditionally batch reactors, and more recently flow reactors, have been extensively used for the discovery and synthesis of new nanomaterials.…”

Section: Discussionmentioning

confidence: 99%

Importance of Monitoring the Synthesis of Light‐Interacting Nanoparticles – A Review on In Situ, Ex Situ, and Online Time‐Resolved Studies

Pinho

Zhang

Hoye

et al. 2022

Advanced Optical Materials

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Reducing the dimensionality of materials from bulk thin films and single crystals to nanocrystals (NCs) and quantum dots This review paper analyzes the importance of monitoring the synthesis of plasmonic and optoelectronic materials to provide a mechanistic understanding of their nucleatiçon and growth, as well as crucial kinetic insights to enable their future development. Light-interacting nanoparticles present strong size-property relationships, such that size control is at the core of any synthetic development. However, conventional ex situ characterization of these materials has heavily limited their development to simple trial-and-error approaches. Over the last decade, the development of in situ and online characterization capabilities has transformed the understanding of mechanistic models. In addition, time-resolved data are able to reveal the step rate, even for phenomena taking place in the microsecond timescale (i.e., nucleation), thanks to the use of micro-flow-reactors. However, the literature contains a few disagreements and inaccuracies, which are considered to be due to the general lack of attention and control on mixing (relevant when mixing time is comparable to the reaction time), and the presence of additives during synthesis (e.g., stabilizers). Finally, it is believed that recent in situ monitoring development coupled with reactor design brings unique opportunities to not only synthesize nanoparticles in a reproducible and controllable manner, but also gives data-rich approaches for self-regulated and automated systems.

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“…With the increased interest in nanobiology and nanoparticle research [1][2][3], there have been many studies in recent years on the use of nanocarriers, such as inorganic nanomaterials, as loading structures for hemoglobin (Hb). Tu et al suggested the use of tetraethyl-orthosilicate-based nanoparticles as a hemoglobin carrier system [4].…”

Section: Introductionmentioning

confidence: 99%

A Novel Artificial Hemoglobin Carrier Based on Heulandite-Calcium Mesoporous Aluminosilicate Particles

Jordanoski

Drobne

Repar

et al. 2022

IJMS

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Tetraethyl-orthosilicate (TEOS)-based nanoparticles are most extensively used as a silica-based hemoglobin carrier system. However, TEOS-based nanoparticles induce adverse effects on the hemoglobin structure. Therefore, a heulandite-calcium-based carrier was investigated as a novel silica-based hemoglobin carrier system. The heulandite-calcium mesoporous aluminosilicate particles (MSPs) were fabricated by a patented tribo-mechanical activation process, according to the manufacturer, and its structure was assessed by X-ray diffraction analysis. Upon hemoglobin encapsulation, alternation in the secondary and tertiary structure was observed. The hemoglobin-particle interactions do not cause heme degradation or decreased activity. Once encapsulated inside the particle pores, the hemoglobin shows increased thermal stability, and higher loading capacity per gram of particles (by a factor of >1.4) when compared to TEOS-based nanoparticles. Futhermore, we introduced a PEGlyted lipid bilayer which significantly decreases the premature hemoglobin release and increases the colloidal stability. The newly developed hemoglobin carrier shows no cytotoxicity to human umbilical vein endothelial cells (HUVEC).

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Controlling nanoparticle formation from the onset of nucleation through a multi-step continuous flow approach

Cited by 9 publications

References 37 publications

An Alkanethiol-Surfactant Bilayer To Prevent Shape Conversion of Anisotropic Silver Nanoparticles and Probe Their Formation Mechanisms

An Alkanethiol-Surfactant Bilayer To Prevent Shape Conversion of Anisotropic Silver Nanoparticles and Probe Their Formation Mechanisms

Importance of Monitoring the Synthesis of Light‐Interacting Nanoparticles – A Review on In Situ, Ex Situ, and Online Time‐Resolved Studies

A Novel Artificial Hemoglobin Carrier Based on Heulandite-Calcium Mesoporous Aluminosilicate Particles

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