Reactive Changes in the Resistive of the Hemomycocirculatory Bed Following the Action of 1% of Methacrylic Acid Ester

Abstract

The morphometric study conducted has revealed that the effect of a 1% methacrylic acid-methyl ester solution affects the resistive section of the microvasculatory bed of the submandibular salivary gland lobes. The study was conducted on 30 white outbred male rats, 10 of which made up the control group of animals and 20 animals made up experimental group, whose oral mucosa was treated with 1% methacrylic acid-methyl ester solution for 30 days. After euthanasia of animals in 14 and 30 days, samples of the submandibular gland were embedded into epon-812. Semi-thin sections were stained with polychrome dye. A quantitative analysis of the results of the morphometric study and statistical processing of the morphometric data was performed using standard statistical methods using the Excel program. The outer diameter and lumen diameter of arterioles were measured. The thickness of the vascular wall was calculated using the formula VWTh = Dz-Dt / 2. On the 14th day, in response to the action of 1% methacrylic acid-methyl ester solution, the average outer arteriole diameter decreased by 13.04%, the diameter of the of arteriole lumen by 20.77%. There is a significant increase in the average thickness of the vascular wall by 5.45%, the value of which was 2.90 microns. On the 13th day of the study, it was found out that the average values ​​of the outer diameter of the arterioles increased by 5.04% (p <0.05), compared with the control group. The lumen diameter was significantly larger by 15% that the values ​​in the control group of animals, and the average vascular wall thickness was significantly lower by 18.91% than the values ​​in the control group of animals (p <0.05). Normalization of indicators for the 30th day has not been defined. Thus, the effect of 1% methacrylic acid-methyl ester solution on the arterioles of the submandibular salivary gland lobes is characterized by vascular spasms in the early stages, and vascular dilatation in the later stages of the experiment.