Reactive angioendotheliomatosis following implantation of a knee metallic device

González‐Pérez, R.; Lagrán, Z. Martínez de; Soloeta, R.; Saracibar, N

doi:10.1111/ijd.12343

Cited by 7 publications

(5 citation statements)

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“…Most reported cases have been associated with systemic disorders including chronic infections, cryoglobulinemia, lymphoproliferative disorders, renal failure, hepatic failure, autoimmune disease, post solid organ or bone marrow transplantation, immunosuppression, and hypertension [1]. RAE in association with dermal amyloid angiopathy [1], and metallic prosthesis [1,2] has also been reported. Despite its diverse clinical associations, RAE is poorly defined and its pathogenesis remains unknown, probably in part due to its rarity [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Reactive angioendotheliomatosis of the intestine in Crohn’s disease: A second case report with 10-year follow up

Lee

Jennings

2015

Human Pathology: Case Reports

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Reactive angioendotheliomatosis (RAE) is a rare cutaneous vascular disorder, usually associated with systemic diseases. RAE has previously been described only in the skin, with the single exception of one case involving the intestine in a patient with Crohn's disease, associated with lower gastrointestinal bleeding. We report a second case of intestinal RAE, also associated with Crohn's disease and bleeding, with 10-year follow up. A 48-year-old man with Crohn's disease presented with fever and chills associated with an abscess-like lesion in the ileum. The patient underwent ileocecectomy. The specimen showed histologic features of Crohn's disease. In addition, a florid vascular lesion was identified in the ileum, proximal to the area involved by Crohn's enteritis. Histomorphology and immunophenotype of this vascular lesion was consistent with RAE. The lesion was intimately associated with mesenteric hematoma, suggestive of bleeding. No abscess was identified. Currently, 10 years after surgery, the patient has persistent ileal Crohn's enteritis, but otherwise remains healthy with no evidence of vascular disorder. Although rarely reported, intestinal RAE in Crohn's disease may be under recognized. The co-existence of Crohn's disease in our patient and prior case report suggests that immunologic factors underlie its pathogenesis. Pathologic recognition of the lesion and awareness of the existence of intestinal RAE in hemorrhagic forms of Crohn's disease is warranted.

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Section: Introductionmentioning

confidence: 99%

“…RAE in association with dermal amyloid angiopathy [1], and metallic prosthesis [1,2] has also been reported. Despite its diverse clinical associations, RAE is poorly defined and its pathogenesis remains unknown, probably in part due to its rarity [1,2].…”

Section: Introductionmentioning

confidence: 99%

Reactive angioendotheliomatosis of the intestine in Crohn’s disease: A second case report with 10-year follow up

Lee

Jennings

2015

Human Pathology: Case Reports

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“…We read with great interest the case report by González‐Pérez et al . published in the April issue of the International Journal of Dermatology .…”

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confidence: 95%

“…The authors described the case of a 61‐year‐old woman who developed a reactive intravascular angioendotheliomatosis (RIA) following the placement of a prosthetic metallic device in the knee. After removal of the prosthesis, the lesion began to improve and completely disappeared within three months …”

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confidence: 99%

“…In the case described by González‐Pérez et al ., orthopedic surgery for implantation of a knee metallic device would inevitably damage the local lymphatic network and sensory nerve fibers. As a consequence, the alteration of immune cell trafficking and the disrupted nerve conduction could result in an immune destabilization of the involved area with local hypoxia and synthesis of angiogenic cytokines, leading to endothelial cell proliferation.…”

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confidence: 99%

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Reactive angioendotheliomatosis following implantation of a knee metallic device: an instance of immunocompromised district

Caccavale

Gambardella

2015

Int J Dermatology

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philic and do not readily cross cell membranes; 2 thus, they are not appreciably stored within tissues. Rather, the particles' small size enables them to be easily filtered by the kidneys without tubular resorption. 2 Given normal renal function, indigo carmine is cleared from the circulation and seen in the bladder within 5-7 minutes. 2 The side effects of indigo carmine dye are largely cardiovascular and most commonly involve hypertension and a reflex bradycardia with decreased stroke volume, leading to decreased cardiac output. Rarely, dysrhythmias, cardiac arrest, and anaphylaxis have also been reported. 1 Uncommonly, indigo carmine dye can extravasate from the peripheral line into the skin and cause a dramatic but asymptomatic blue discoloration. The three prior instances of indigo carmine extravasation were also noticed upon the completion of surgery. 1-3 As in the present case, the previously reported patients did not experience any symptoms and, other than the discoloration and edema of the affected arm, showed unremarkable findings on examination. In all cases, the discoloration resolved within 24-48 hours without any cutaneous or cardiovascular sequelae.Although indigo carmine dye extravasation into the skin is a benign, transient condition, its presentation is dramatic and can induce significant anxiety in both patients and clinicians who are unfamiliar with this complication. Dermatologists consulted for such rashes can reassure patients and the healthcare team that the discoloration will resolve completely without resultant tissue

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Necrotic Vascular Plaques on Breasts and Upper Arm

El-Darouti

Al-Ali

2019

Challenging Cases in Dermatology Volume 2

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Reactive angioendotheliomatosis following implantation of a knee metallic device

Cited by 7 publications

References 5 publications

Reactive angioendotheliomatosis of the intestine in Crohn’s disease: A second case report with 10-year follow up

Reactive angioendotheliomatosis of the intestine in Crohn’s disease: A second case report with 10-year follow up

Reactive angioendotheliomatosis following implantation of a knee metallic device: an instance of immunocompromised district

Necrotic Vascular Plaques on Breasts and Upper Arm

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