Reactivation of Polyomavirus hominis 1 (BKV) during pregnancy and the risk of mother-to-child transmission

Kalvatchev, Z.; Slavov, Svetoslav Nanev; Shtereva, Milkana; Savova, S

doi:10.1016/j.jcv.2008.08.002

Cited by 29 publications

(21 citation statements)

References 14 publications

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“…Viruria was detected for 3-54% of pregnant women, while viraemia was found to be less frequent. 1,10,11,23 In accordance with literature, in this study 13% of pregnant women had active BKPyV replication resulting in viruria, but no viraemia. The possible effect of BK virus replication during pregnancy is not clarified.…”

Section: Discussionsupporting

confidence: 90%

“…Although viral DNA was demonstrated in foetal tissues 24 the hypothesis of transplacental transmission was not confirmed. 10,11 Recently serological evidence for vertical transmission of BKPyV was published. 9 Hitherto, there are no prevalence data about the novel WU, KI and human polyomavirus 9 during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…1 Transient immunosuppression due to pregnancy may lead to reactivation of BKPyV resulting in generally asymptomatic viruria with frequency of 3-54%. 1,[9][10][11] Beside viruria, BKPyV viraemia was also detected in pregnant women. 11 The pathogenic role of the novel WUPyV, KIPyV and HPyV9 is far from clear, only speculative.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Novel human polyomaviruses in pregnancy: Higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9

Csoma

Sápy

Mészáros

et al. 2012

Journal of Clinical Virology

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26Background: Immunosuppression due to pregnancy may lead to higher susceptibility to 27 infections and reactivation of latent infections, such as BK polyomavirus (BKPyV). There is 28 lack of information about the prevalence of novel human polyomavirus 9 (HPyV9), WU 29 (WUPyV) and KI (KIPyV) during pregnancy. 30Objectives: To study whether pregnancy results in higher prevalence of HPyV9, WUPyV, 31KIPyV and their correlation with BKPyV. 32Study design: Plasma, urine and throat swab samples from 100 pregnant and 100 non 33 pregnant women were screened for the presence of WUPyV, KIPyV, HPyV9 and BKPyV by 34 PCR. 35Results: No WUPyV DNA was detected in plasma, urine and respiratory samples from 36

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Novel human polyomaviruses in pregnancy: Higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9

Csoma

Sápy

Mészáros

et al. 2012

Journal of Clinical Virology

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“…However, little is known of the dynamics of polyomavirus excretion in the urine of healthy adults. Among pregnant women, the prevalence of BKV excretion has been reported to be as low as 4% and high as 54% in point‐prevalence studies [Markowitz et al, 1991; Jin, 1993; Tsai et al, 1997; Bhattacharjee and Chakraborty, 2004; Kalvatchev et al, 2008]. Our recent longitudinal analysis of polyomavirus shedding in pregnancy found that 54.9% of subjects excreted BKV during pregnancy [McClure et al, 2012].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of urinary polyomavirus shedding in healthy adult women

Kling

Wright

Katz

et al. 2012

Journal of Medical Virology

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The hypothesis was examined that physiologic variation of estrogen concentrations during the menstrual cycle can provoke BK virus (BKV) excretion. BKV and JCV viral loads were determined in urine specimens obtained almost daily from 20 healthy, non‐pregnant women over 2 months. Asymptomatic urinary shedding of BKV was observed in 123 (12.0%) of 1,021 specimens from 11 (55%) study subjects. Two subjects excreted JCV in their urine, with one subject excreting detectable JCV in all urine specimens. Analysis of 36 complete menstrual cycles revealed no difference in the prevalence of BKV excretion between pre‐ovulatory and post‐ovulatory phases of the menstrual cycle. The unexpected day‐to‐day variability in BKV excretion suggests that as yet unidentified factors may contribute to the periodic shedding of BKV by healthy women. J. Med. Virol. 84:1459–1463, 2012. © 2012 Wiley Periodicals, Inc.

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“…Some investigators have suggested that the mother–fetus pathway may be an alternative or complementary route of BKV transmission [Taguchi et al, 1975; Gibson et al, 1981; Kalvatchev et al, 2008], although this has been denied by others [Coleman et al, 1980; Chang et al, 1996]. One previous study of 300 pregnant women did not find any evidence of the transplacental transmission of BKV [Boldorini et al, 2008].…”

Section: Introductionmentioning

confidence: 99%

BK virus sequences in specimens from aborted fetuses

Boldorini

Allegrini

Miglio

et al. 2010

Journal of Medical Virology

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Given the conflicting results of the few published studies, the aim of this retrospective molecular-based study of 10 aborted fetuses that underwent complete autopsy and 10 placentas was carried out to determine whether BK polyomavirus (BKV) can be transmitted transplacentally. The interruption of pregnancy was due to a miscarriage (five cases) or a prenatal diagnosis of severe intrauterine malformations (five cases). Samples from the brain, heart, lung, thymus, liver, and kidney were taken from each fetus, and two samples were obtained from all of the placentas. The presence of BKV was investigated by means of PCR using primers specific for the transcription control region (TCR) and viral capsidic protein 1 (VP1) and DNA extracted from formalin-fixed, paraffin-embedded tissue. BKV genome was detected in 22 of 60 samples (36.6%) from seven fetuses (70%), regardless of the cause of abortion: VP1 was amplified in 12 samples (54%), TCR in seven (32%), and both in three (14%). VP1 was also detected in one placental sample. BKV sequences were most frequently detected in heart and lung (five cases), but sequence analyses of TCR and VP1 revealed a high degree of genomic variability among the samples taken from different organs and the placenta. These results indicate that BKV can cross the placenta during pregnancy and become latent in fetal organs other than the kidney and brain (previously considered the main targets of BKV latency). This may happen in early pregnancy and does not seem to be associated with an increased risk of abortion.

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Reactivation of Polyomavirus hominis 1 (BKV) during pregnancy and the risk of mother-to-child transmission

Cited by 29 publications

References 14 publications

Novel human polyomaviruses in pregnancy: Higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9

Novel human polyomaviruses in pregnancy: Higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9

Dynamics of urinary polyomavirus shedding in healthy adult women

BK virus sequences in specimens from aborted fetuses

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