Reactions to ionizing radiation

Goldschmidt, Herbert; Sherwin, William K.

doi:10.1016/s0190-9622(80)80067-3

Cited by 103 publications

(55 citation statements)

References 78 publications

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“…17 Lesions resembling keratoses called pseudorecidives sometimes appear in the immediate postradiation period, may resemble tumor recurrences, and often spontaneously resolve without treatment. 17,18 Hair loss may be transient after therapy, and new hair may continue to return for up to a year. Alopecia due to follicular fibrosis may be permanent.…”

Section: Acute Radiation Dermatitismentioning

confidence: 99%

Radiation dermatitis: Clinical presentation, pathophysiology, and treatment 2006

Hymes

Strom

Fife

2006

Journal of the American Academy of Dermatology

516

551

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Section: Acute Radiation Dermatitismentioning

confidence: 99%

Radiation dermatitis: Clinical presentation, pathophysiology, and treatment 2006

Hymes

Strom

Fife

2006

Journal of the American Academy of Dermatology

516

551

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“…16], Further more. it has been shown that the true substrate for tyrosi nase is the superoxide anion radical (O, ) and not molecu lar oxygen (O,) as previously suggested [17][18][19][20], Based on these recent biochemical observations, a new concept for the treatment of vitiligo was proposed.…”

Section: Introductionmentioning

confidence: 97%

Treatment of Vitiligo with a Topical Application of Pseudocatalase and Calcium in Combination with Short-Term UVB Exposure: A Case Study on 33 Patients

Schallreuter

Wood²,

Lemke³

et al. 1995

Dermatology

141

105

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Thirty-three patients with the depigmentation disorder vitiligo were successfully treated with a new topical application of pseudocatalase, calcium and short-term UVB light exposure. First repigmentation occurred in the majority of cases after 2–4 months. Complete repigmentation on the face and dorsum of the hands appeared in 90% of the group. In all patients, active depigmentation was arrested. None of them developed new lesions during treatment. No recurrence of the disease was observed during a 2-year follow-up. The rationale for this pilot study originated from a recent understanding of vitiligo at the molecular level. The involved epidermis produces hydrogen peroxide due to defective tetrahydrobiopterin recycling and increased monoamine oxidase A activity, whereupon catalase is inactivated. In addition, calcium homeostasis is perturbed in the affected skin. The substitution for insufficient catalase by a pseudocatalase together with calcium and UVB exposure lead to effective repigmentation.

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“…Patients undergoing repeated cardiac catheterisation and coronary angioplasty procedures have developed chronic radiodermatitis 67 This skin lesion may result in ulceration and transformation into an invasive squamous cell carcinoma with a high risk of metastasis 8. We describe two patients in whom chronic radiodermatitis developed after being exposed twice to radiation during cardiac catheterisation.…”

mentioning

confidence: 99%

Chronic radiodermatitis following cardiac catheterisation: a report of two cases and a brief review of the literature

Dehen

Vilmer²,

Humilière³

et al. 1999

Heart

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Cardiac angiography produces one of the highest radiation exposures of any commonly used diagnostic x ray procedure. Recently, serious radiation induced skin injuries have been reported after repeated therapeutic interventional procedures using prolonged fluoroscopic imaging. Two male patients, aged 62 and 71 years, in whom chronic radiodermatitis developed one to two years after two consecutive cardiac catheterisation procedures are reported. Both patients had undergone lengthy procedures using prolonged fluoroscopic guidance in a limited number of projections. The resulting skin lesions were preceded, in one case, by an acute erythema and took the form of a delayed pigmented telangiectatic, indurated, or ulcerated plaque in the upper back or below the axilla whose site corresponded to the location of the x ray tube during cardiac catheterisation. Cutaneous side eVects of radiation exposure result from direct damage to the irradiated tissue and have known thresholds. The diagnosis of radiation induced skin injury relies essentially on clinical and histopathological findings, location of skin lesions, and careful medical history. Interventional cardiologists should be aware of this complication, because chronic radiodermatitis may result in painful and resistant ulceration and eventually in squamous cell carcinoma. (Heart 1999;81:308-312)

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Reactions to ionizing radiation

Cited by 103 publications

References 78 publications

Radiation dermatitis: Clinical presentation, pathophysiology, and treatment 2006

Radiation dermatitis: Clinical presentation, pathophysiology, and treatment 2006

Treatment of Vitiligo with a Topical Application of Pseudocatalase and Calcium in Combination with Short-Term UVB Exposure: A Case Study on 33 Patients

Chronic radiodermatitis following cardiac catheterisation: a report of two cases and a brief review of the literature

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