Radiation dermatitis: Clinical presentation, pathophysiology, and treatment 2006

Hymes, Sharon R.; Strom, Eric A.; Fife, Caroline E.

doi:10.1016/j.jaad.2005.08.054

Cited by 518 publications

(582 citation statements)

References 168 publications

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“…Patient-related factors include larger breast size, high BMI, overlapping skin folds, the sensitivity of the exposed skin region, smoking and nutritional status, preexisting skin conditions (e.g., psoriasis), and individual (genetic) susceptibility. However, there is still some controversy on which factors really determine the individual risk for developing severe skin reactions [48][49][50].…”

Section: Rdmentioning

confidence: 99%

“…Therefore, preventing and managing RD is an important part of the patient care during RT. Current treatment options for RD include topical agents such as hydrophilic creams, gels, ointments, and wound dressings [50,51]. The MASCC developed some clinical practice guidelines for the prevention and treatment of acute and late radiation skin reactions [52].…”

Section: Rdmentioning

confidence: 99%

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The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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Breast cancer is the most common cancer in women worldwide, with an incidence of 1.7 million in 2012. Breast cancer and its treatments can bring along serious side effects such as fatigue, skin toxicity, lymphedema, pain, nausea, etc. These can substantially affect the patients' quality of life. Therefore, supportive care for breast cancer patients is an essential mainstay in the treatment. Low-level light therapy (LLLT) also named photobiomodulation therapy (PBMT) has proven its efficiency in general medicine for already more than 40 years. It is a noninvasive treatment option used to stimulate wound healing and reduce inflammation, edema, and pain. LLLT is used in different medical settings ranging from dermatology, physiotherapy, and neurology to dentistry. Since the last twenty years, LLLT is becoming a new treatment modality in supportive care for breast cancer. For this review, all existing literature concerning the use of LLLT for breast cancer was used to provide evidence in the following domains: oral mucositis (OM), radiodermatitis (RD), lymphedema, chemotherapy-induced peripheral neuropathy (CIPN), and osteonecrosis of the jaw (ONJ). The findings of this review suggest that LLLT is a promising option for the management of breast cancer treatment-related side effects. However, it still remains important to define appropriate treatment and irradiation parameters for each condition in order to ensure the effectiveness of LLLT.

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Section: Rdmentioning

confidence: 99%

Section: Rdmentioning

confidence: 99%

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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“…Most patients had breast cancer (38%), followed by pelvic (32%), head-and-neck (22%), and other cancers (8%). Field size was 80-320 cm 2 (mean: 177 cm 2 ), and the dose of radiotherapy was 40-70 Gy (mean: 54 Gy). Concurrent chemotherapy was administered in 20 patients.…”

Section: Introductionmentioning

confidence: 99%

Aloe vera for Prevention of Radiation-Induced Dermatitis: A Self-Controlled Clinical Trial

et al. 2013

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To evaluate an Aloe vera lotion for prevention of radiation-induced dermatitis, all patients with a prescription of radiotherapy to a minimum dose of 40 Gy were eligible provided that their treatment area could be divided into two symmetrical halves. Patients were given a lotion of Aloe vera to use on one half of the irradiated area, with no medication to be used on the other half. The grade of dermatitis in each half was recorded weekly until 4 weeks after the end of radiotherapy. The trial enrolled 60 patients (mean age: 52 years; 67% women). Most patients had breast cancer (38%), followed by pelvic (32%), head-and-neck (22%), and other cancers (8%). Field size was 80–320 cm2 (mean: 177 cm2), and the dose of radiotherapy was 40–70 Gy (mean: 54 Gy). Concurrent chemotherapy was administered in 20 patients. From week 4 to week 6 of radiotherapy and then at weeks 2 and 4 after radiotherapy, the mean grade of dermatitis with and without Aloe vera was 0.81 and 1.10 (p < 0.001), 0.96 and 1.28 (p < 0.001), 1.00 and 1.57 (p = 0.006), 0.59 and 0.79 (p = 0.003), and 0.05 and 0.21 (p = 0.002) respectively. Age and radiation field size had a significant effect on the grade of dermatitis. Based on these results, we conclude that the prophylactic use of Aloe vera reduces the intensity of radiationinduced dermatitis.

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“…[4][5][6] Living tissues are usually able to repair themselves when attacked, but when repeatedly irradiated, the tissue repair capacity is affected. 7 One effect of the repeated irradiation is the radiodermitis or radiodermatitis, a high incidence reaction characterized by skin lesions similar to superficial burns that may ulcerate and develop local infections. 8 These lesions tend to be quite painful, to limit the movements depending on the affected area 9 and to decrease the quality of life of patients.…”

Section: Introductionmentioning

confidence: 99%

Smoking influences the Occurrence of Radiodermatitis in Head and Neck-irradiated Patients

Kuga¹,

Tonetto²,

Caetano³

et al. 2017

World Journal of Dentistry

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Radiation dermatitis: Clinical presentation, pathophysiology, and treatment 2006

Cited by 518 publications

References 168 publications

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

Aloe vera for Prevention of Radiation-Induced Dermatitis: A Self-Controlled Clinical Trial

Smoking influences the Occurrence of Radiodermatitis in Head and Neck-irradiated Patients

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