Reactions of some annelated 2-aminothiophenes with two naphthoquinones

Fondjo, Emmanuel Sopbué; Döpp, D.

doi:10.3998/ark.5550190.0007.f05

Cited by 6 publications

(2 citation statements)

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“…The thienocoumarin (413) and 2,3-dichloro-1,4-naphthoquinone (1) in refluxing THF in the presence of triethylamine produced 414; Scheme 87 [53].…”

Section: Miscellaneous Reactions Of 23-dichloro-14-naphthoquinonementioning

confidence: 99%

“…Aminothiazole derivatives (101) and (102) on treatment with 2,3-dichloro-1,4-naphthoquinone (1) in presence of K2CO3 resulted in the formation of 2-[(3-chloro-1,4-naphthoquinonyl)amino]-1,3thiazoles( 104) and ( 105); Scheme 23 [52]. Analogous reaction of 2,3-dichloro-1,4naphthoquinone (1) with 103 in refluxing toluene in the presence of Et3N gave aminoquinone (6106) in poor yield [53].…”

Section: Introductionmentioning

confidence: 99%

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Synthetic and Biological Utility of 2,3-Dichloro-1,4-Naphthoquinone: A Review

Maurya

2020

Int. J. Res. Granthaalayah

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2,3-Dichloro-1,4-naphthoquinones (dichlone) have attracted considerable attention for the construction of biologically active tricyclic and tetracyclic 1,4-quinones and other derivatives. A diversified reaction of 2,3-dichloro-1,4-naphthoquinones such as cycloaddition, condensation, photo induced and nucleophilic substitution reactions with suitable nucleophiles viz. carbon, nitrogen, oxygen, sulfur, selenium etc have been explored. Various synthesized compounds have also explored for their biological activity such as antifungal, antibacterial, anticancer, antiplatlet, anti-inflamentry, anti-allergic and anti HIV. This review describes the chemistry and biological activity of compounds synthesized from 2,3-dichloro-1,4-naphthoquinones during the last three decades.

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“…The thienocoumarin (413) and 2,3-dichloro-1,4-naphthoquinone (1) in refluxing THF in the presence of triethylamine produced 414; Scheme 87 [53].…”

Section: Miscellaneous Reactions Of 23-dichloro-14-naphthoquinonementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthetic and Biological Utility of 2,3-Dichloro-1,4-Naphthoquinone: A Review

Maurya

2020

Int. J. Res. Granthaalayah

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Synthesis of 3‐arylazo‐6‐oxopyridazin‐5‐carbonitriles: A versatile precursor for condensed arylazopyridazin‐6‐ones

Al‐Mousawi

El‐Apasery

Al‐Kandery

et al. 2008

Journal of Heterocyclic Chem

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hydrazono]-butan-2-one were produced via coupling the (E) 2-oxopropanal-1-phenylhydrazone or (E) 2-oxobutanal-1-(4-methylphenyl)hydrazone with aromatic diazonium salts. These formazanes condensed readily with ethyl cyanoacetate to yield 5-methyl-3-oxo-2-phenyl-6-phenylazo-2,3-dihydropyridazine-4-carbonitrile compound (9a), 5-ethyl-3-oxo-2-p-tolyl-6-p-tolylazo-2,3-dihydropyridazine-4-carbonitrile and/or 5-ethyl-3-oxo-2,6-di-p-tolyl-2,3-dihydropyridazine-4-carbonitrile that reacted with sulphur in presence of piperidine to yield the aminothienopyridazinones. The latter reacted with electron poor olefins and acetylenes to yield aminophthalazines. Compound (9a) reacted also with benzylidenemalononitrile to yield the arylazophthalazinone.

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