Reactions and platelet increments after transfusion of platelet concentrates in plasma or an additive solution: a prospective, randomized study

Abstract

Transfusion of PCs in PAS-2 significantly reduces the incidence of reactions. The 1-hour and 20-hour CCIs after transfusion of PCs in PAS-2 were significantly lower than the CCIs after transfusion of PCs in plasma. Because storage conditions of both PCs were found to be optimal, the decrease in CCIs after transfusion of PCs prepared in PAS-2 may be caused by rapid elimination of a subpopulation of P-selectin-positive platelets from the circulation.

Platelets: Testing, Dosing and the Storage Lesion—Recent Advances

“…Numerous platelet additive solutions have been formulated with this idea in mind. Because additive solutions replace 70-80% of the plasma in the original platelet unit, these formulations are predicted to have additional benefits: reduced allergic and febrile transfusion reactions, 33 decreased transfusion of unwanted antibodies (e.g., ABO, HLA) and increased plasma made available for fractionation. 34 Additive solutions could afford technical benefits for pathogen reduction methods as well (PAS-III, or "Inactisol" was created for the EuroSPRITE pathogen reduction study).…”

Clinical Evaluation of Platelet Concentrates Either in Plasma or in Additive Solution

“…PAS displays several advantages over the use of plasma for preparation of PCs. These benefits include reduction of the number of allergic reactions [8,9], while more plasma becomes available for fractioning. Due to the absence of anti-A and anti-B, ABO-incompatible transfusions are better tolerated [10], life-threatening anaphylaxis or febrile nonhemolytic transfusion reactions after transfusion of PCs is a serious clinical problem caused by the sensitizing of recipients to plasma components, such as cytokines [11].…”

“…The use of an additive solution as the major component of the platelet storage medium was first described by Rock et al [12]. The preparation and storage of PCs in a platelet additive solution (PAS-2) have been shown to result in acceptable storage conditions [9] but require the carryover of substantial (30%) amounts of plasma for success. Platelet additive solutions can be used as a substitute for plasma in order to recover plasma for other purposes, to avoid transfusion of large volumes of plasma to patients, to improve storage conditions, and to make possible photochemical treatment for viral inactivation of PCs [13].…”

“…Ninety-nine platelet concentrates (43 with plasma and 56 with PAS-2) were transfused. The transfusion trigger for platelets was 20x10 9 or less. One hour after each transfusion, corrected count increments (CCIs) were calculated, presence of hemorrhage and adverse reactions were recorded.…”

Comparison of harvesting methods and clinical application of apheresis platelet concentrates with additive solution

“…В последнее десятилетие на фоне роста количест-ва заместительных трансфузий [21][22][23][24] все больший интерес представляет заготовка КТ с применением добавочных растворов (ДР) для снижения риска раз-вития негемолитических посттрансфузионных реак-ций. Кроме того, использование ДР при заготовке КТ способствует сохранению функциональной активно-сти тромбоцитов при длительных сроках хранения [25][26][27].…”