Reaction of Olefins with Nitriles under Solvent-Free Conditions Using Molecular Iodine as a Catalyst in the Presence of Water

Recent developments in Ritter reaction

“…In 2012, Y. Hanzawa et al 21 reported another Ritter reaction of alkenes with molecular iodine (I 2 , 20 mol%) as the catalyst. In their protocol, the reaction of chiral (+)-camphene with benzonitrile under solvent-free conditions in the presence of water (100 mol%) caused skeletal rearrangement of the camphene and amidation, resulting in racemic (AE)-N-isobornylbenzamide (19) in good yield (Scheme 15).…”

“…Many useful compounds have been synthesized through Ritter or Ritter-type reaction, including asymmetrical di-and tri-substituted ureas, 3-substituted-3amino-oxindoles, 4-acyl-aminotetrahydroindazoles, N-(4-iodo-1,3-diarylbutyl) acetamides, 4-amidopiperidine derivatives and aza-bicyclic alkaloids. [4][5][6][7][8]10,11,[13][14][15][16][17][19][20][21][22][23][24]27,[30][31][32][33][34][35][36] This review focuses on new ndings in Ritter or Ritter-type reaction in the last four years and provides a concise overview of recent progress in this area.…”