Reaction of Cysteine with Nitrogen Mustards and their N-oxides.

Nature of the addition of dienophiles to the acridizinium ion

“…b Xma" 271 µ (log « 3.76), Xmm 244 µ (log e 3.51). 6 Acetonitrile was used instead of acetic acid as the solvent for the reaction. d Colorless needles from methanol-ethyl acetate.…”

“…As may be seen in Figure 1 the reaction rate increases with increased electron release of the para substituent p-nitrostyrene reacting slowest and p-methoxystyrene fastest, an exact parallel to the observations of Sauer and Wiest.6 °From the bromide of the anhydride 1 as the perchlorate salt. 6 Physical data (except nmr) for this compound from ref 3. ' Signal overlapped by 5.64-6.10 (m, four, CHtCHi).…”