REACTION OF 4-ARYL-2,3-DIHYDRO-2-PHENYL-l//-l,5-BENZODIAZEPINES WITH 2-CHLOROACETYL CHLORIDE. SYNTHESIS OF N-ACYLAND AZETO[l,2-a]-l,5-BENZODIAZEPINES

Chalcone derived benzoheterodiazepines for medicinal applications: A Two‐pot and one‐pot synthetic approach

“…Benzoheterodiazepine is a seven-membered heterocyclic ring [19] with two heteroatoms [20], nonplanar [21], and pharmacophoric [22,23] properties. Benzodiazepines and benzothiazepines are examples of benzoheterodiazepine derivatives that are commercially used in medicine such as nevirapine [24], fuligocandin B [25], tiazesim [26], halazepam [27], diltiazem [28], triazolam [29], gastrozepin [30], clozapine (a) [31], olanazapine (b) [32], 3-carbamoyl-1,-5-benzodiazapine (c), clobazam (antiepileptic agent), (d) and neoplasm inhibitors (e) (Figure 1) [31,33].…”