Chalcone derived benzoheterodiazepines for medicinal applications: A Two‐pot and one‐pot synthetic approach

Abstract

The production of effective drugs has continuously been a challenging process for researchers due to the occurrence of resistive diseases. Drugs derived from natural product-based compounds as an active scaffold have gained interest in drug development due to a wide range of biological properties. Benzoheterodiazepines, a natural product derivative of bicyclic chalcones have been

Coumarin‐Chalcones Generated from 3‐Acetylcoumarin as a Promising Agent: Synthesis and Pharmacological Properties

“…[108] compounds in reasonable-to-good yields which were shown in Table 2. [113,114] According to the proposed mechanism, [147] addition of guanidine to chalcone (4) forms intermediate A. Intermediate B is formed by the intramolecular nucleophilic addition of the amine to the carbonyl group, which is followed by the elimination of water to give compound 49 (Scheme 10).…”

“…(the mechanism was redrawn from literature.) [147] Scheme 11. Mechanism for the synthesis of coumarinpyridinone (52).…”

New Chalcone Derivatives as Anticancer and Antioxidant Agents: Synthesis, Molecular Docking Study and Biological Evaluation

“…Many synthesized chemical compounds have shown various biological activities [2][3][4][5][6][7][8][9]. Among those compounds, chalcones and their derivatives have received increasing attention from researchers because of their various activities, such as anti-bacterial [10][11][12], antifungal [13,14], anti-cancer [15][16][17], anti-Alzheimer [18,19], anti-inflammatory [20,21], and antioxidant [22][23][24], in addition to their importance in the industrial field [25][26][27].…”