Reaction-free and MMP-independent fluorescent probes for long-term mitochondria visualization and tracking

Abstract

We present two mitochondria-immobilized fluorescent probes ECPI-12 and IVPI-12 for long-term mitochondria visualization and tracking regardless of MMP changes.

Observation of crystallisation dynamics by crystal-structure-sensitive room-temperature phosphorescence from Au(I) complexes

“…Over the past two decades, materials in which the aggregation of molecules enhances the radiative decay of excited states have been developed, and this phenomenon is recognised as aggregation-induced emission (AIE) [15][16][17][18][19][20][21][22][23][24] . Many types of organic AIE-active molecules (AIEgens) have been found to be non-emissive in dilute solutions but emissive in condensed phases [20][21][22][23][24] . We consider that AIEgens may allow crystallisation processes to be visualised because of the drastic enhancement in luminescence intensity caused by the formation of aggregates.…”

Enhanced three-photon activity triggered by the AIE behaviour of a novel terpyridine-based Zn(ii) complex bearing a thiophene bridge

“…4b), indicating that DZ1 is a mitochondrial membrane potential-independent mitochondrial probe. As reported,32,33 the hydrophobicity of cationic probes plays a vital part in mitochondria staining. Therefore, the hydrophobicity (as modelled by log P values) of DZ1 was measured (log P of DZ1 = 0.489), which corroborated the moderate hydrophobicity of DZ1 .…”

A NIR-I light-responsive superoxide radical generator with cancer cell membrane targeting ability for enhanced imaging-guided photodynamic therapy

“…S41c and d †), electrostatic interaction and long-alkyl chain-induced hydrophobicity would enable it to rmly stain mitochondria, which was also reported in the previous literature. 60 The turn-on uorescence when EBD-5 anchored on mitochondria could be attributed to the interaction between EBD-5 and mitochondrial DNA [61][62][63][64][65][66] (Fig. S41e †).…”