A NIR-I light-responsive superoxide radical generator with cancer cell membrane targeting ability for enhanced imaging-guided photodynamic therapy

Abstract

Photodynamical therapy (PDT), as an emerging treatment modality, which takes advantage of reactive oxygen species (ROS) initiated by light illumination to ablate tumor, has suffered from the limited treatment depth,...

NIR-absorbing superoxide radical and hyperthermia photogenerator via twisted donor-acceptor-donor molecular rotation for hypoxic tumor eradication

“…For example, the inherent defects of most O 2 −• photogenerators, such as short maximum absorption wavelength (less than 750 nm) and poor photo/chemical stability, would limit the therapeutic efficacy against deep tumors [34,35]. Moreover, normal nonplanar O 2 −• photogenerators tend to aggregate in physiological environments which might induce the quenching of O 2 −• [36,37].…”

1,1′-(Ethane-1,2-diyl)bis(4-{(E)-2-[4-(dimethylamino)phenyl]ethenyl}pyridin-1-ium) dibromide ethanol 0.67-solvate

“…Double pyridine-bromide salts have been proposed as radical generators in cancer treatment (Bu et al, 2020). We now describe the synthesis and structure of the title solvated molecular salt, 3C 32 H 36 Br 2 N 4 2+ Á6Br À Á2C 2 H 5 OH.…”

An ultra-stable bio-inspired bacteriochlorin analogue for hypoxia-tolerant photodynamic therapy

“…To address this issue, some strategies such as two-photon excitation (TPE) technique 4,5 and upconversion nanoparticles (UCNPs) 6,7 had been introduced for the therapy of deep tumors, but the complex equipment and the low conversion efficiency will bring about new problems for the clinic application 8,9 . Thus, PSs with strong NIR (700-1000 nm) absorption, which display deeper tissue penetration and minimized photodamage, have attracted intense research efforts for eradicating tumor in deep site [10][11][12] . Moreover, the PDT efficacy is also greatly suffered from the hypoxia environment of solid tumors, since the conventional PSs consume oxygen to produce reactive oxygen species (ROS) for inhibiting tumor growth (type II mechanism).…”

“…8,9 Thus, PSs with strong NIR (700–1000 nm) absorption, which display deeper tissue penetration and minimized photodamage, have attracted intense research efforts for eradicating tumors in deep sites. 10–12 Moreover, PDT efficacy also greatly suffers from the hypoxic environment of solid tumors, since conventional PSs consume oxygen to produce reactive oxygen species (ROS) for inhibiting tumor growth (type II mechanism). A great number of contributions have been recently dedicated to defeating the hypoxia of tumors by increasing oxygen concentration, 13,14 including in situ oxygen production at tumor sites via catalytic reactions 15–17 and oxygen delivery into tumors.…”