Reaction-based fluorescent and chemiluminescent probes for formaldehyde detection and imaging

Huang, Shumei; Li, Zejun; Liu, Minghui; Zhou, Mengjiao; Weng, Jintao; He, Yuhang; Yin, Jie; Zhang, Huatang; Sun, Hongyan

doi:10.1039/d1cc05644a

Cited by 28 publications

(13 citation statements)

References 125 publications

(151 reference statements)

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“…The pathological and physiological functions inspire researchers to design innovative FA probes for biological roles and usage investigations. [17][18][19] However, Polymers 2022, 14, 2416 2 of 17 as a potential therapy method, the design of nano-carriers with FA controlled release is still limited [20].…”

Section: Introductionmentioning

confidence: 99%

Photo-Responsive Micelles with Controllable and Co-Release of Carbon Monoxide, Formaldehyde and Doxorubicin

Zheng

Dong

et al. 2022

Polymers

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Endogenous gases have attracted much attention due to their potent applications in disease therapies. The combined therapy, including gaseous molecules and other medicines that can create synergistic effects, is a new way for future treatment. However, due to the gaseous state, gas utilization in medical service is still limited. To pave the way for future usage, in this work, an amphiphilic block copolymer containing nitrobenzyl ether, 3-hydroxyflavone (3-HF) derivatives and ether linker was constructed. The nitrobenzyl ether group endows the polymer with a photo-responsive character. Upon light illumination, 3-HF derivatives can be triggered for carbon monoxide (CO) release. The ether linker can also be released emitting formaldehyde (FA). The self-assembly induced micelle can encompass medicine, e.g., doxorubicin (DOX), into it and a controlled release of DOX can be realized upon light illumination. As far as we know, there is no report on the combination donor of CO and DOX and this is the first attempt on the co-release of CO, FA and DOX.

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Section: Introductionmentioning

confidence: 99%

Photo-Responsive Micelles with Controllable and Co-Release of Carbon Monoxide, Formaldehyde and Doxorubicin

Zheng

Dong

et al. 2022

Polymers

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“…Among the various fluorescence‐based detection methodology of RCSs, most of the efforts have been inclined towards monocarbonyls such as formaldehyde (FA), carbon monoxide (CO), and phosgene. However, recently fluorescent probes for dicarbonyls such as glyoxal (GO), methylglyoxal (MGO), and malondialdehyde (MDA) have been started to be explored among the thirty so far reported RCSs [23,29,37,38] . The limitations in traditional analytical techniques are well addressed by the synergistic advancement of the fluorescence probe development and the progress of imaging instruments.…”

Section: Introductionmentioning

confidence: 99%

“…However, recently fluorescent probes for dicarbonyls such as glyoxal (GO), methylglyoxal (MGO), and malondialdehyde (MDA) have been started to be explored among the thirty so far reported RCSs. [23,29,37,38] The limitations in traditional analytical techniques are well addressed by the synergistic advancement of the fluorescence probe development and the progress of imaging instruments. The design of fluorescent probes, development of recognition unit, sensing mechanism, and application of the RCSs are briefly described below.…”

Section: Introductionmentioning

confidence: 99%

“…Formaldehyde, the most superficial monocaronyl reactive species, is widely used in industrial applications, including buildings, constructions, paints, automobiles. [23,29,37,38] It is also extensively used in the food industry as a preservative and healthcare research for tissue fixation and vaccine preservation. [39] Apart from these exogenous sources, FA is continuously being generated in human physiology during various enzymatic and metabolic pathways.…”

Section: Introductionmentioning

confidence: 99%

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Activity‐Based Fluorescent Probes for Sensing and Imaging of Reactive Carbonyl Species (RCSs)

Jana

Baruah

Samanta

2022

Chemistry An Asian Journal

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This review explains various strategies for developing fluorescent probes to detect reactive carbonyl species (RCS). There are several mono and diacarbonyls among 30 varieties of reactive carbonyl species (RCSs) so far discovered, which play pivotal roles in pathological processes such as cancer, neurodegenerative diseases, cardiovascular disease, renal failure, and diabetes mellitus. These RCSs play essential roles in maintaining ion channel regulation, cellular signaling pathways, and metabolisms. Among RCSs, carbon monoxide (CO) is also utilized for its cardioprotective, anti-inflammatory, and anti-apoptotic effects. Fluorescence-based non-invasive optical tools have come out as one of the promising methods for analyzing the concentrations and co-localizations of these small metabolites. There has been a tremendous eruption in developing fluorescent probes for selective detection of specific RCSs within cellular and aqueous environments due to their high sensitivity, high spatial and temporal resolution of fluorescence imaging. Fluorescence-based sensing mechanisms such as intramolecular charge transfer (ICT), photoinduced electron transfer (PeT), excited-state intramolecular proton transfer (ESIPT), and fluorescence resonance energy transfer (FRET) are described. In particular, probes for dicarbonyls such as methylglyoxal (MGO), malondialdehyde (MDA), along with monocarbonyls that include formaldehyde (FA), carbon monoxide (CO) and phosgene are discussed. One of the most exciting advances in this review is the summary of fluorescent probes of dicarbonyl compounds.

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“…Nowadays, the research developments for selective detection of FA have been focused on two reaction types involving Schiff base (amine and hydrazine) and 2-aza-Cope rearrangement reactions (Scheme 1). [12][13][14][15] These two main approaches are highly selective and sensitive to FA but the 2-aza-Cope reaction basedapproach showed much longer detection time than the Schiff base reaction (Table S1, ESI †). 12 Thus, it is still challenging to develop uorescent probes based on 2-aza-Cope rearrangement with fast detection time.…”

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confidence: 99%

Quinolizinium-based fluorescent probes for formaldehyde detection in aqueous solution, serum, and test strip via 2-aza-Cope rearrangement

et al. 2022

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Reaction-based fluorescent and chemiluminescent probes for formaldehyde detection and imaging

Abstract: The major developments of fluorescent and chemiluminescent formaldehyde probes have been summarized in this highlight.

Cited by 28 publications

References 125 publications

Photo-Responsive Micelles with Controllable and Co-Release of Carbon Monoxide, Formaldehyde and Doxorubicin

Photo-Responsive Micelles with Controllable and Co-Release of Carbon Monoxide, Formaldehyde and Doxorubicin

Activity‐Based Fluorescent Probes for Sensing and Imaging of Reactive Carbonyl Species (RCSs)

Quinolizinium-based fluorescent probes for formaldehyde detection in aqueous solution, serum, and test strip via 2-aza-Cope rearrangement

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