Re: Spaide et al.: Volume-rendering optical coherence tomography angiography of macular telangiectasia type 2 (Ophthalmology 2015;122:2261-9)

Chen, Zhongping; Huang, David; Izatt, Joseph A.; Wang, Ke; Werner, John S.; Yasuno, Yoshiaki

doi:10.1016/j.ophtha.2015.10.013

Cited by 5 publications

(1 citation statement)

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“…1,7 These regions can be assessed for the presence of new vessels, loss of capillary perfusion and increased vessel tortuosity by using qualitative data. [38][39][40] The OptovueTM software also contains the ability to use quantitative data through fractal analysis or pixel counting methods to assess the fovea avascular zone (FAZ), parafoveal area and areas of foveal non-perfusion but also other peripheral retinal areas as well by using decorrelation values. 30,35…”

Section: Basic Principles and Algorithms In Oct-amentioning

confidence: 99%

<p>Optical Coherence Tomography Angiography in Neurodegenerative Diseases: A Review</p>

Tsokolas

Tsaousis

Diakonis

et al. 2020

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Background: Optical coherence tomography angiography (OCT-A) has emerged as a novel, fast, safe and non-invasive imaging technique of analyzing the retinal and choroidal microvasculature in vivo. OCT-A captures multiple sequential B-scans performed repeatedly over a specific retinal area at high speed, thus enabling the composition of a vascular map with areas of contrast change (high flow zones) and areas of steady contrast (slow or no flow zones). It therefore provides unique insight into the exact retinal or choroidal layer and location at which abnormal blood flow develops. OCTA has evolved into a useful tool for understanding a number of retinal pathologies such as diabetic retinopathy, age-related macular degeneration, central serous chorioretinopathy, vascular occlusions, macular telangiectasia and choroidal neovascular membranes of other causes. OCT-A technology is also increasingly being used in the evaluation of optic disc perfusion and has been suggested as a valuable tool in the early detection of glaucomatous damage and monitoring progression. Objective: To review the existing literature on the applications of optical coherence tomography angiography in neurodegenerative diseases. Summary: A meticulous literature was performed until the present day. Google Scholar, PubMed, Mendeley search engines were used for this purpose. We used 123 published manuscripts as our references. OCT-A has been utilized so far to describe abnormalities in multiple sclerosis (MS), Alzheimer's disease, arteritic and non-arteritic optic neuropathy (AION and NAION), Leber's hereditary optic neuropathy (LHON) papilloedema, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), Wolfram syndrome, migraines, lesions of the visual pathway and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). It appears that OCT-A findings correlate quite well with the severity of the aforementioned diseases. However, OCT-A has its own limitations, namely its lack of wide-field view of the peripheral retina and the inaccurate interpretation due to motion artifacts in uncooperative groups of patients (e.g. children). Larger prospective longitudinal studies will need to be conducted in order to eliminate the aforementioned limitations.

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