Novel biomarker of sphericity and cylindricity indices in volume-rendering optical coherence tomography angiography in normal and diabetic eyes: a preliminary study

Maloca, Peter; Spaide, Richard F.; Carvalho, Emanuel R. de; Studer, H; Hasler, Pascal W.; Scholl, Hendrik P. N.; Heeren, Tjebo; Schottenhamml, Julia; Balaskas, Konstantinos; Tufail, Adnan; Egan, Catherine

doi:10.1007/s00417-019-04582-x

Cited by 11 publications

(12 citation statements)

References 66 publications

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“…A limit could be that currently no reproducibility test has been performed. Nevertheless, for the reproducibility of the described OCTA method, a mean intraclass correlation coefficient (ICC) of 0.845 or a mean ICC of 0.999, and an intraclass coefficient of variation of 0.07 or 0.0006, was reported earlier 39 so that it is comparable to standard en face OCTA methods 49 , 50 .…”

Section: Discussionmentioning

confidence: 83%

“…As retinal vessels do not grow in two dimensions, the ordinary 2D OCTA display method is evidently only able to show limited areas of the retinal vasculature. Therefore, the scope of this study was to extend the current OCTA method with a novel approach into the 3D realm and to measure the naturally occurring variations of retinal vessel surface areas in healthy subjects 37 – 39 . This is of particular interest because the vascular surface in the retina represents the most important diffusion barrier and participates in the exchange of small molecules such as oxygen and glucose from the blood to the surrounding tissue.…”

Section: Discussionmentioning

confidence: 99%

“…2 ). Image post-processing included the application of an automatic script written in MATLAB R2017a (MathWorks Inc., Natick, USA), through which the retinal flow signal was separated and made suitable for the measurement of the total 3D vessel surface area; details regarding this method, including its reproducibility, were previously reported on 53 . Briefly summarized:

Figure 2 Presentation of image processing in three-dimensional optical coherence tomography angiography.…”

Section: Methodsmentioning

confidence: 99%

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Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography

Maloca

Feu-Basilio

Schottenhamml

et al. 2022

Sci Rep

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Optical coherence tomography angiography (OCTA) enables three-dimensional, high-resolution, depth-resolved flow to be distinguished from non-vessel tissue signals in the retina. Thus, it enables the quantification of the 3D surface area of the retinal vessel signal. Despite the widespread use of OCTA, no representative spatially rendered reference vessel surface area data are published. In this study, the OCTA vessel surface areas in 203 eyes of 107 healthy participants were measured in the 3D domain. A Generalized Linear Model (GLM) model analysis was performed to investigate the effects of sex, age, spherical equivalent, axial length, and visual acuity on the OCTA vessel surface area. The mean overall vessel surface area was 54.53 mm2 (range from 27.03 to 88.7 mm2). OCTA vessel surface area was slightly negatively correlated with age. However, the GLM model analysis identified axial length as having the strongest effect on OCTA vessel surface area. No significant correlations were found for sex or between left and right eyes. This is the first study to characterize three-dimensional vascular parameters in a population based on OCTA with respect to the vessel surface area.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Figure 2 Presentation of image processing in three-dimensional optical coherence tomography angiography.…”

Section: Methodsmentioning

confidence: 99%

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Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography

Maloca

Feu-Basilio

Schottenhamml

et al. 2022

Sci Rep

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“…Therefore we labeled the vascular network of 21 3D OCTA datasets. Numerous medical studies 6 – 9 have shown that the morphology of the vascular network is suitable as biomarkers for various pathological changes of the retina. In this work we first describe the 3D appearance of the retinal vessel plexus of dry age-related macular degeneration cases, which are captured with an OCTA device.…”

Section: Introductionmentioning

confidence: 99%

Axial Stretching of Vessels in the Retinal Vascular Plexus With 3D OCT-Angiography

Kuhlmann

Rothaus

Jiang

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose The purpose of this study is to describe and quantify the nonpathological axial stretching in the retinal vascular plexus in three-dimensional (3D) optical coherence tomography angiography (OCTA) images. Methods The 3D vascular network underneath the inner limiting membrane of OCTA volumes was labeled as ground truth (GT) data. To analyze the cross-section area of the vessels the width and depth of the vessels in the GT data were computed and an elliptical quotient was proposed to quantify the axial stretching. Results A total of 21 3D OCTA volumes were labeled. It was found that the vessels in 3D OCTA images are stretched in the direction of the A-Scan by a factor of 2 . 46 ± 1 . 82 with a median of 2 . 24. Furthermore, a larger cross-section area leads to higher axial stretching. Conclusions The elliptical shape of the cross-section area of the vessel does not match with the expected pathology of the vascular network in the human eye. Therefore a correction of the volume data before a 3D analysis is recommended. Translational Relevance This work gives a systematic insight to the stretched shape of vessels in 3D OCTA images and is relevant for further clinical research analyzing the 3D vascular network.

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“…However, the latest visualization tools allowed for combining of structural OCT and OCTA to present threedimensional (3D) retinal vascular models. 12,13 Such spatial volume-rendering technique demonstrated the geometric association between morphological pathologies, such as cystoid edema, and flow voids in specific vascular layers, which are otherwise undiscoverable in 2D. 14 Few studies to date have analyzed the retinal or choroidal vasculature in STDG using 2D-OCTA.…”

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confidence: 99%

Negative Vessel Remodeling in Stargardt Disease Quantified With Volume-Rendered Optical Coherence Tomography Angiography

Reich

Dreesbach

Boehringer

et al. 2021

Retina

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Purpose: To quantify retinal vasculature changes in Stargardt disease1 (STGD1) with volume-rendered optical coherence tomography angiography. Methods: Optical coherence tomography angiography volumes from healthy subjects and two subgroups of patients with STGD1 with the presence/absence of definitely decreased autofluorescence areas were compared. Optical coherence tomography angiography vessel surface area and vessel volume were measured in central zones (Z) of 1-, 2-, and 3-mm diameter. Results: Twenty nine eyes of 15 patients with STGD1 (20/9 eyes with/without definitely decreased autofluorescence) and 30 eyes of 15 controls contributed data. An enlarged foveal avascular zone was found in patients with STGD1 without and even more with definitely decreased autofluorescence associated with a vessel rarefication in central and also paracentral zones with unnoticeable autofluorescence. Vessel surface area and vessel volume were reduced in both STGD1 subgroups for all zones (P < 0.0001). Stargardt disease 1 eyes when compared to without definitely decreased autofluorescence showed reduced vessel surface area and vessel volume in Z2+3 (both P < 0.05). Conclusion: Volume rendering of optical coherence tomography angiography in STGD1 shows a reduced retinal flow in the central macula. This is most likely secondary to loss of neurosensory tissue with disease progression and therefore not likely be favorably influenced by gene transfer and retinal pigment epithelial transplantation. Retinal blood flow assessed by 3D volume-rendered optical coherence tomography angiography could serve as surrogate marker for vascular changes of the central retina.

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Novel biomarker of sphericity and cylindricity indices in volume-rendering optical coherence tomography angiography in normal and diabetic eyes: a preliminary study

Cited by 11 publications

References 66 publications

Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography

Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography

Axial Stretching of Vessels in the Retinal Vascular Plexus With 3D OCT-Angiography

Negative Vessel Remodeling in Stargardt Disease Quantified With Volume-Rendered Optical Coherence Tomography Angiography

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