The purpose of this research program was to design and evaluate prototype artificially-cooled gloves that enhance thermal comfort as assessed by skin temperature, sweat rate, manual dexterity and perceived comfort. Three multiple-layered glove systems were sequentially designed and tested under simulated environmental conditions in a controlled laboratory chamber. Artificial-cooling and a liner were successful in reducing skin temperature and perceived moisture-related discomfort. Manual dexterity was hampered by one liner design.