RDRio Mycobacterium tuberculosis strains associated with isoniazid resistance in Northern Mexico

Bocanegra-García, Virgilio; Cortez-de-la-Fuente, Luis Jesús; Nakamura-López, Yuko; González, Gloria M.; Rivera, Gildardo; Palma-Nicolás, José Prisco

doi:10.1016/j.eimc.2020.07.003

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…This long sequence polymorphism results from a homologous recombination deletion between Rv3346c and Rv355c genes located 26.3 kb apart (22). This LAM variant, called MTB RD Rio is associated with multidrug resistance and distributed worldwide (22,(24)(25)(26)(27). The prevalence of MTB RD Rio varies in Latin America: 30 to 51.9% in Brazil (22,28), 69.8% in Venezuela (19), 37% in Colombia (17,21,29), 31% in Peru (21,30), 20% in Argentina (21), 10% in Paraguay (18) and 3% in Chile (21).…”

Section: Introductionmentioning

confidence: 99%

Prevalence, drug resistance, and genotypic diversity of the RDRio subfamily of Mycobacterium tuberculosis in Ecuador: a retrospective analysis for years 2012–2016

Castro-Rodriguez,

Franco-Sotomayor,

Benitez-Medina

et al. 2024

Front. Public Health

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IntroductionA major sublineage within the Mycobacterium tuberculosis (MTB) LAM family characterized by a new in-frame fusion gene Rv3346c/55c was discovered in Rio de Janeiro (Brazil) in 2007, called RDRio, associated to drug resistance. The few studies about prevalence of MTB RDRio strains in Latin America reported values ranging from 3% in Chile to 69.8% in Venezuela, although no information is available for countries like Ecuador.MethodsA total of 814 MTB isolates from years 2012 to 2016 were screened by multiplex PCR for RDRio identification, followed by 24-loci MIRU-VNTR and spoligotyping.ResultsA total number of 17 MTB RDRio strains were identified, representing an overall prevalence of 2.09% among MTB strains in Ecuador. While 10.9% of the MTB isolates included in the study were multidrug resistance (MDR), 29.4% (5/17) of the RDRio strains were MDR.DiscussionThis is the first report of the prevalence of MTB RDRio in Ecuador, where a strong association with MDR was found, but also a very low prevalence compared to other countries in Latin America. It is important to improve molecular epidemiology tools as a part of MTB surveillance programs in Latin America to track the transmission of potentially dangerous MTB stains associated to MDR TB like MTB RDRio.

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Section: Introductionmentioning

confidence: 99%

Prevalence, drug resistance, and genotypic diversity of the RDRio subfamily of Mycobacterium tuberculosis in Ecuador: a retrospective analysis for years 2012–2016

Castro-Rodriguez,

Franco-Sotomayor,

Benitez-Medina

et al. 2024

Front. Public Health

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Molecular epidemiology of Mycobacterium tuberculosis in Ecuador: Recent advances and future challenges

Castro-Rodriguez,

Franco-Sotomayor,

Orlando

et al. 2024

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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Mycobacterium tuberculosis lineage 4 associated with cavitations and treatment failure

et al. 2023

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Background Mycobacterium tuberculosis genotyping has been crucial to determining the distribution and impact of different families on disease clinical presentation. The aim of the study was to evaluate the associations among sociodemographic and clinical characteristics and M. tuberculosis lineages from patients with pulmonary tuberculosis in Orizaba, Veracruz, Mexico. Methods We analyzed data from 755 patients whose isolates were typified by 24-loci mycobacterial interspersed repetitive unit–variable number of tandem repeats (MIRU–VNTR). The associations among patient characteristics and sublineages found were evaluated using logistic regression analysis. Results Among M. tuberculosis isolates, 730/755 (96.6%) were assigned to eight sublineages of lineage 4 (Euro-American). Alcohol consumption (adjusted odds ratio [aOR] 1.528, 95% confidence interval (CI) 1.041–2.243; p = 0.030), diabetes mellitus type 2 (aOR 1.625, 95% CI 1.130–2.337; p = 0.009), sputum smear positivity grade (3+) (aOR 2.198, 95% CI 1.524–3.168; p < 0.001) and LAM sublineage isolates (aOR 1.023, 95% CI 1.023–2.333; p = 0.039) were associated with the presence of cavitations. Resistance to at least one drug (aOR 25.763, 95% CI 7.096–93.543; p < 0.001) and having isolates other than Haarlem and LAM sublineages (aOR 6.740, 95% CI 1.704–26.661; p = 0.007) were associated with treatment failure. In a second model, multidrug resistance was associated with treatment failure (aOR 31.497, 95% CI 5.119–193.815; p < 0.001). Having more than 6 years of formal education was not associated with treatment failure. Conclusions Knowing M. tuberculosis genetic diversity plays an essential role in disease development and outcomes, and could have important implications for guiding treatment and improving tuberculosis control.

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RDRio Mycobacterium tuberculosis strains associated with isoniazid resistance in Northern Mexico

Cited by 3 publications

References 11 publications

Prevalence, drug resistance, and genotypic diversity of the RDRio subfamily of Mycobacterium tuberculosis in Ecuador: a retrospective analysis for years 2012–2016

Prevalence, drug resistance, and genotypic diversity of the RDRio subfamily of Mycobacterium tuberculosis in Ecuador: a retrospective analysis for years 2012–2016

Molecular epidemiology of Mycobacterium tuberculosis in Ecuador: Recent advances and future challenges

Mycobacterium tuberculosis lineage 4 associated with cavitations and treatment failure

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