RDoC is necessary, but very oversold

Frances, Allen

doi:10.1002/wps.20102

Cited by 55 publications

(27 citation statements)

References 7 publications

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“…The same problems afflict the classification system in the International Classification of Diseases. (ICD), which overlaps with the DSM (Frances, 2014). We remain saddled with a diagnostic paradigm that (a) relies almost exclusively on superficial signs and symptoms and (b) is largely divorced from pathology and etiology.…”

Section: The Dsm and Its Discontentsmentioning

confidence: 99%

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The Research Domain Criteria (RDoC): An analysis of methodological and conceptual challenges

Lilienfeld

2014

Behaviour Research and Therapy

186

176

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Section: The Dsm and Its Discontentsmentioning

confidence: 99%

“…RDoC must avoid the same missteps (Frances, 2014). For RDoC to succeed, it will need to proceed with humility and with full recognition of the hard-won lessons of the past.…”

Section: Concluding Thoughtsmentioning

confidence: 99%

The Research Domain Criteria (RDoC): An analysis of methodological and conceptual challenges

Lilienfeld

2014

Behaviour Research and Therapy

186

176

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“…The hue and cry regarding the most controversial changes in DSM-5, such as the deletion of the bereavement criterion for major depressive disorder or the jettisoning of hypochondriasis as a diagnosis (Frances, 2014), may have obscured a deeper point. With the potential exception of (a) the inclusion of dimensional scales to capture the functioning and impairment associated with major mental disorders and (b) the inclusion of a hybrid prototype-dimensional model for personality disorders, both of which appeared in Section III (“Emerging Measures and Models”), DSM-5 was every bit as neo-Kraepelinian as its predecessors.…”

Section: Dsm and Icd: Origins And Assumptionsmentioning

confidence: 99%

Clashing Diagnostic Approaches: DSM-ICD Versus RDoC

Lilienfeld

Treadway

2016

Annu. Rev. Clin. Psychol.

234

192

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Since at least the middle of the past century, one overarching model of psychiatric classification, namely, that of the Diagnostic and Statistical Manual of Mental Disorders and International Classification of Diseases (DSM-ICD), has reigned supreme. This DSM-ICD approach embraces an Aristotelian view of mental disorders as largely discrete entities that are characterized by distinctive signs, symptoms, and natural histories. Over the past several years, however, a competing vision, namely, the Research Domain Criteria (RDoC) initiative launched by the National Institute of Mental Health, has emerged in response to accumulating anomalies within the DSM-ICD system. In contrast to DSM-ICD, RDoC embraces a Galilean view of psychopathology as the product of dysfunctions in neural circuitry. RDoC appears to be a valuable endeavor that holds out the long-term promise of an alternative system of mental illness classification. We delineate three sets of pressing challenges – conceptual, methodological, and logistical/pragmatic – that must be addressed for RDoC to realize its scientific potential, and conclude with a call for further research, including investigation of a rapprochement between Aristotelian and Galilean approaches to psychiatric classification.

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“…26,27 The incorporation of preclinical translational studies of fear extinction at both the behavioral and molecular level into treatments (e.g., exposure therapy and DCS) demonstrates the potential value of the integrated approach proposed by RDoC, and the burgeoning literature on neuroplasticity and epigenetics further highlights that this concern is unwarranted, as one cannot study neural circuits and genetics without considering experience. 25,28 Old dichotomies of nature versus nurture, or biology versus experience, are obsolete and have been so for decades.…”

Section: Rdoc Matrixmentioning

confidence: 99%

The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children

Kaufman

Gelernter

Hudziak

et al. 2015

Journal of the American Academy of Child & Adolescent Psych

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Objective The Research Domain Criteria (RDoC) project was initiated to develop, for research purposes, new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures. This article reviews the rationale behind the RDoC program, its goals, and central tenets; discusses application of an RDoC framework to research with maltreated children; and highlights some clinical implications of this work. Method Published RDoC papers were reviewed, together with relevant preclinical and clinical studies that guide our work on risk and resilience in maltreated children. Results The ultimate long-term goal of the RDoC initiative is precision medicine in psychiatry. In the interim, the RDoC initiative provides a framework to organize research to help develop the database required to derive a new psychiatric nomenclature that can appropriately match treatments to patients. The primary focus of RDoC is on neural circuitry, with levels of analyses that span from molecules to behavior. There has been some concern that the RDoC framework is reductionist, with an overemphasis on neural circuits and genetics; however, the briefly reviewed, burgeoning literature on neuroplasticity and epigenetics highlights that this concern is unwarranted, as one cannot study neural circuits and genetics without considering experience. Conclusion The study of maltreated children has a number of advantages for the RDoC project, including the following: study of a subset of patients who are often not responsive to standard interventions; examination of a relatively homogenous sample with onset of psychopathology proposed to be associated with stress-related mechanisms; and well-established, relevant animal models to facilitate translational research.

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RDoC is necessary, but very oversold

Cited by 55 publications

References 7 publications

The Research Domain Criteria (RDoC): An analysis of methodological and conceptual challenges

The Research Domain Criteria (RDoC): An analysis of methodological and conceptual challenges

Clashing Diagnostic Approaches: DSM-ICD Versus RDoC

The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children

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