The Research Domain Criteria (RDoC): An analysis of methodological and conceptual challenges

Lilienfeld, Scott O.

doi:10.1016/j.brat.2014.07.019

Cited by 186 publications

(184 citation statements)

References 114 publications

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“…Although some evidence from both the previous literature and our work points toward negative or depressive symptoms being more related to the reported finding, they require further confirmation. The future of this line of research fits nicely within the specifications laid out by the RDoC project, although it also faces similar challenges, such as the measurement error, and the biological and psychometric limitations of proposed endophenotypes and their relationship to behavior (Cuthbert, 2014b;Lilienfeld, 2014;Weinberger and Goldberg, 2014). Upcoming studies on reward and psychopathology will have to use bigger sample sizes and a broader range of clinical measurements in order to be able to obtain a compelling evidence of the relationship between brain activation and everyday behavior.…”

Section: Resultsmentioning

confidence: 96%

“…However, within each of these categories there is great heterogeneity in the type and severity of symptoms and, similarly, it is common to have overlap in symptoms between the different diagnoses (Lilienfeld, 2014). Recently the Research Domain Criteria (RDoC) framework has been proposed as an alternative framework in order to advance the understanding of mental disorders .…”

Section: Abstract: Reward System Ventral Striatum Monetary Incentivmentioning

confidence: 99%

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Reward Processing in Motivational and Affective Disorders

Ryan¹,

Skandali²

2016

Frontiers Research Topics

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Section: Resultsmentioning

confidence: 96%

Section: Abstract: Reward System Ventral Striatum Monetary Incentivmentioning

confidence: 99%

Reward Processing in Motivational and Affective Disorders

Ryan¹,

Skandali²

2016

Frontiers Research Topics

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“…Im Gegensatz zu neurologischen Störungen gibt es bei den psychischen Störungen bislang keine klaren Hinweise, dass tatsächlich ein pathologischer Gehirnprozess die Grundlage der Störung ist [Lilienfeld, 2014]. Vielmehr belegt die neurowissenschaftliche Forschung eindeutig, dass viele Hirnveränderungen durch Erleben und Verhalten erst bedingt werden, wie z.B.…”

Section: Psychische Störungen Basieren Auf Psychologischen Mechanismeunclassified

Lost in Translation: Psychologische Mechanismen und Psychotherapie

Flor

2015

Verhaltenstherapie

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In diesem Artikel möchte ich zu den folgenden Punkten Stellung nehmen: 1. Psychische Störungen basieren auf psychologischen Mechanismen und müssen aus diesen heraus verstanden werden 2. Psychische Störungen sind keine Hirnerkrankungen - jedoch kann das Verständnis psychischer Störungen durch die Kenntnis biologischer Prozesse verbessert werden. 3. Psychotherapie muss an diesen Mechanismen ansetzen und sollte von einer störungsorientierten zu einer mechanismenorientierten Therapie kommen. 4. Dies setzt eine mechanismenorientierte Diagnostik voraus. Der RDoc-Ansatz ist ein wichtiger Versuch, aber er greift zu kurz, was die psychologischen Mechanismen betrifft. 5. Pharmakotherapie und andere somatische Therapien können Psychotherapie unterstützen, wenn sie zur Veränderung der psychologischen Mechanismen eingesetzt werden. 6. Psychotherapie kann auch bei organischen Erkrankungen wirksam eingesetzt werden. 7. Wir sind noch weit davon entfernt, die Erkenntnisse der Grundlagenforschung in der Psychologie und den Neurowissenschaften in die Konstruktion neuer Psychotherapien einzubauen. Dafür brauchen wir bessere Förderinstrumente als die bislang zur Verfügung stehenden und eine politische und finanzielle Priorität für die Therapieforschung.

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“…There are some challenges in this regard. [67][68][69] First involves the reality that the language construct is closely inter-related with other RDoC-related cognitive, affective, and social constructs. 70,71 The neuroscience of language is fairly well established, 72 with a number of neural regions and connections identified that are critical to specific language functions.…”

Section: Potential Challenges In Applying Rdoc To Thought Disordermentioning

confidence: 99%

Can RDoC Help Find Order in Thought Disorder?

Cohen

Fedechko

et al. 2017

Schizophrenia Bulletin

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Thought disorder is a pernicious and nonspecific aspect of numerous serious mental illnesses (SMIs) and related conditions. Despite decades of empirical research on thought disorder, our present understanding of it is poor, our clinical assessments focus on a limited set of extreme behaviors, and treatments are palliative at best. Applying a Research Domain Criteria (RDoC) framework to thought disorder research offers advantages to explicate its phenotype; isolate its mechanisms; and develop more effective assessments, treatments, and potential cures. In this commentary, we discuss ways in which thought disorder can be understood within the RDoC framework. We propose operationalizing thought disorder within the RDoC construct of language using psycholinguistic sciences, to help objectify and quantify language within individuals; technologically sophisticated paradigms, to allow naturalistic behavioral sampling techniques with unprecedented ecological validity; and computational modeling, to account for a network of interconnected and dynamic linguistic, cognitive, affective, and social functions. We also highlight challenges for understanding thought disorder within an RDoC framework. Thought disorder likely does not occur as an isomorphic dysfunction in a single RDoC construct, but rather, as multiple potential dysfunctions in a network of RDoC constructs. Moreover, thought disorder is dynamic over time and context within individuals. In sum, RDoC is a useful framework to integrate multidisciplinary research efforts aimed at operationalizing, understanding, and ameliorating thought disorder.

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The Research Domain Criteria (RDoC): An analysis of methodological and conceptual challenges

Cited by 186 publications

References 114 publications

Reward Processing in Motivational and Affective Disorders

Reward Processing in Motivational and Affective Disorders

Lost in Translation: Psychologische Mechanismen und Psychotherapie

Can RDoC Help Find Order in Thought Disorder?

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