RD Rio Mycobacterium tuberculosis lineage in the Brazil/Paraguay/Argentina triple border

Almeida, Aryadne Larissa de; Scodro, Regiane Bertin de Lima; Carvalho, Hayalla Corrêa de; Costacurta, Giovana Ferreira; Baldin, Vanessa Pietrowski; Santos, Nathally Claudiane Souza; Ghiraldi-Lopes, Luciana Dias; Campanerut‐Sá, Paula Aline Zanetti; Siqueira, Vera Lúcia Dias; Caleffi-Ferracioli, Katiany Rizzieri; Shibata, Flávia Kazumi; Sprada, Andressa; Cardoso, Rosilene Fressatti

doi:10.1016/j.tube.2018.03.008

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…Additionally, a phylogenetic analysis was done using 12-loci MIRU-VNTR, including all the MTB RD Rio strains reported in the bibliography ( 18 , 43 ), as well as the strains identified in the current study for Ecuador. This analysis is detailed in the Minimum Spanning Tree (MST) in the Figure 3 , where the maximum locus difference within a clonal complex was set at 2.…”

Section: Resultsmentioning

confidence: 99%

Prevalence, drug resistance, and genotypic diversity of the RDRio subfamily of Mycobacterium tuberculosis in Ecuador: a retrospective analysis for years 2012–2016

Castro-Rodriguez,

Franco-Sotomayor,

Benitez-Medina

et al. 2024

Front. Public Health

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IntroductionA major sublineage within the Mycobacterium tuberculosis (MTB) LAM family characterized by a new in-frame fusion gene Rv3346c/55c was discovered in Rio de Janeiro (Brazil) in 2007, called RDRio, associated to drug resistance. The few studies about prevalence of MTB RDRio strains in Latin America reported values ranging from 3% in Chile to 69.8% in Venezuela, although no information is available for countries like Ecuador.MethodsA total of 814 MTB isolates from years 2012 to 2016 were screened by multiplex PCR for RDRio identification, followed by 24-loci MIRU-VNTR and spoligotyping.ResultsA total number of 17 MTB RDRio strains were identified, representing an overall prevalence of 2.09% among MTB strains in Ecuador. While 10.9% of the MTB isolates included in the study were multidrug resistance (MDR), 29.4% (5/17) of the RDRio strains were MDR.DiscussionThis is the first report of the prevalence of MTB RDRio in Ecuador, where a strong association with MDR was found, but also a very low prevalence compared to other countries in Latin America. It is important to improve molecular epidemiology tools as a part of MTB surveillance programs in Latin America to track the transmission of potentially dangerous MTB stains associated to MDR TB like MTB RDRio.

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Section: Resultsmentioning

confidence: 99%

Prevalence, drug resistance, and genotypic diversity of the RDRio subfamily of Mycobacterium tuberculosis in Ecuador: a retrospective analysis for years 2012–2016

Castro-Rodriguez,

Franco-Sotomayor,

Benitez-Medina

et al. 2024

Front. Public Health

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“…The RDRio genotype is remarkably frequent in Brazil, although its prevalence varies widely between regions (15.5% to 52%) [38,39]. In Venezuela it was reported in almost 70% of LAM strains [40].…”

Section: Genotypes Associated With Euro-american Lineage In Latin Ame...mentioning

confidence: 99%

Genotyping methods and their contributions to the study of tuberculosis dynamic in Latin America

Castillos de Ibrahim das Neves,

Reis,

Xavier Maio

et al. 2023

J Infect Dev Ctries

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Introduction: Mycobacterium tuberculosis genotyping has impacted evolutionary studies worldwide. Nonetheless, its application and the knowledge generated depend on the genetic marker evaluated and the detection technologies that have evolved over the years. Here we describe the timeline of main genotypic methods related to M. tuberculosis in Latin America and the main findings obtained. Methodology: Systematic searches through the PubMed database were performed from 1993 to May 2021. A total of 345 articles met the inclusion criteria and were selected. Results: Spacer oligonucleotide typing (spoligotyping) was the most widely used method in Latin America, with decreasing use in parallel with increasing use of mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) and whole genome sequencing (WGS). Among the countries, Brazil, Mexico, and Argentina had the most publications, and a considerable part of the articles were in collaboration with Latin American or non-Latin American institutions; a small proportion of studies needed partnerships to perform the genotypic methods. The genotypic methods allowed the identification of M. tuberculosis genotypes with greater capacity for clonal expansion and revealed the predominance of the Euro-American lineage in Latin America. There was a notable presence of the Beijing family in Peru and Colombia. Conclusions: The data obtained demonstrated the importance of expanding collaborative networks of tuberculosis (TB) research groups to countries with low productivity in this area, the commitment of the few Latin American countries to advance TB research, as well as the inestimable value of building a Latin America database, considering ease of population mobility between countries.

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Molecular epidemiology of Mycobacterium tuberculosis in Brazil before the whole genome sequencing era: a literature review

Conceição

Salvato

Gomes

et al. 2021

Mem. Inst. Oswaldo Cruz

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Molecular-typing can help in unraveling epidemiological scenarios and improvement for disease control strategies. A literature review of Mycobacterium tuberculosis transmission in Brazil through genotyping on 56 studies published from 1996-2019 was performed. The clustering rate for mycobacterial interspersed repetitive units - variable tandem repeats (MIRU-VNTR) of 1,613 isolates were: 73%, 33% and 28% based on 12, 15 and 24-loci, respectively; while for RFLP-IS 6110 were: 84% among prison population in Rio de Janeiro, 69% among multidrug-resistant isolates in Rio Grande do Sul, and 56.2% in general population in São Paulo. These findings could improve tuberculosis (TB) surveillance and set up a solid basis to build a database of Mycobacterium genomes.

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RD Rio Mycobacterium tuberculosis lineage in the Brazil/Paraguay/Argentina triple border

Cited by 3 publications

References 39 publications

Prevalence, drug resistance, and genotypic diversity of the RDRio subfamily of Mycobacterium tuberculosis in Ecuador: a retrospective analysis for years 2012–2016

Prevalence, drug resistance, and genotypic diversity of the RDRio subfamily of Mycobacterium tuberculosis in Ecuador: a retrospective analysis for years 2012–2016

Genotyping methods and their contributions to the study of tuberculosis dynamic in Latin America

Molecular epidemiology of Mycobacterium tuberculosis in Brazil before the whole genome sequencing era: a literature review

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