RBE as a Function of Neutron Energy: I. Experimental Observations

Hall, Eric J.; Novak, Judy K.; Kellerer, Albrecht M.; Rossi, Harald H.; Marino, Stephen; Goodman, L.J.

doi:10.2307/3574262

Cited by 76 publications

(35 citation statements)

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“…values for dsb induction are larger than 1 (1.1-2.2). These values are smaller than those commonly observed for cell killing and chromosome aberration frequencies (Hall et al 1975, Bauchinger et al 1975.…”

Section: Discussioncontrasting

confidence: 44%

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Cell Inactivation and DNA Single- and Double-strand Breaks in Cultured Mammalian Cells Irradiated by a Thermal Neutron Beam

Maki

Saito

Kobayashi

et al. 1986

International Journal of Radiation Biology and Related Studies

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The effects on the cellular viability and induction and repair kinetics of DNA strand breaks in HeLa cells were examined after exposure to a thermal neutron beam and compared with those after gamma-irradiation. The thermal neutron survival curve had no initial shoulder. The relative biological effectiveness (r.b.e.) value of the neutron beam was determined to be 2.2 for cell killing (ratio of D0 values), 1.8 and 0.89 for single strand breakage (ssb) by alkaline sedimentation and alkaline elution respectively, and for double strand breakage (dsb) 2.6 by neutral elution. No difference was observed between thermal neutrons and gamma-rays in the repair kinetics of ssb and dsb. It is suggested that the effect induced by the intracellular nuclear reaction, 14N(n,p)14C is mainly responsible for the high r.b.e. values observed.

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Section: Discussioncontrasting

confidence: 44%

“…values of neutrons of various energies for the inactivation of hamster cells. They analysed statistically the previous experimental data (Hall et al 1975) using the dual action model. Relatively high r.b.e.…”

Section: Discussionmentioning

confidence: 99%

Cell Inactivation and DNA Single- and Double-strand Breaks in Cultured Mammalian Cells Irradiated by a Thermal Neutron Beam

Maki

Saito

Kobayashi

et al. 1986

International Journal of Radiation Biology and Related Studies

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“…Kellerer and Rossi 1972, 1973a, Hall, Novak, Kellerer, Rossi, Marino and Goodman 1975, Amols, Di ello and Lane 1975, de Choudens, Gilet, Roux and Fabre 1975, Dobson and Kwan 1976 . The present results show, however, that k must vary by a large fa tor .…”

Section: Dis Ussion 1 ' Site Model' Interpretationmentioning

confidence: 98%

Inactivation and Mutation of Cultured Mammalian Cells by Aluminium Characteristic Ultrasoft X-rays

1977

International Journal of Radiation Biology and Related Studies

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Microdosimetric distributions for aluminium K characteristic ultrasoft X-rays and 4He ion tract intersections are calculated and used to analyse recent biological results obtained with these radiations. Results on inactivation and mutation-induction to thioguanine resistance of both V79 Chinese hamster cells and HF19 human diploid fibroblasts in vitro are analysed in terms of the Kellerer-Rossi "theory of dual radiation action". The small quantum energy of the aluminium X-ray photons and the very short length of the secondary electrons which they produce highlight the inadequacy of the model. It is shown that the model predicts r.b.e. values in conflict with those observed unless an additional variable is introduced, but that the introduction of such a variable creates mathematical inconsistencies. The experimental evidence is contrary to the conventional usage and basis of the model.

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“…RBE values for cell inactivation of neutron energies near 2 MeV have been reported from other facilities, such as RARAF at Columbia University. Hall et al, showed their RBE for 1.0, and 2.0 MeV neutrons against X-ray to be nearly 4.0 (Hall et al, 1975). Kubota et al, showed the RBE values of 0.32, 0.57, and 1.2 MeV neutrons to be 7.6, 6.7, and 5.7, respectively (Kubota et al, 1999).…”

Section: Experimental Procedures For In Vitro Experiments and Prelimimentioning

confidence: 94%

Specifications of a neutron exposure accelerator system for biological effects experiments (NASBEE) in NIRS

Suda¹,

Hagihara²,

Suya³

et al. 2009

Radiation Physics and Chemistry

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RBE as a Function of Neutron Energy: I. Experimental Observations

Cited by 76 publications

References 0 publications

Cell Inactivation and DNA Single- and Double-strand Breaks in Cultured Mammalian Cells Irradiated by a Thermal Neutron Beam

Cell Inactivation and DNA Single- and Double-strand Breaks in Cultured Mammalian Cells Irradiated by a Thermal Neutron Beam

Inactivation and Mutation of Cultured Mammalian Cells by Aluminium Characteristic Ultrasoft X-rays

Specifications of a neutron exposure accelerator system for biological effects experiments (NASBEE) in NIRS

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