Rauvolfianine, a new antimycobacterial glyceroglycolipid and other constituents from <i>Rauvolfia caffra.</i> Sond (Apocynaceae)

Messanga, Robert Ebeh; Serge, Ngono Bikobo Dominique; Zintchem, Auguste Abouem A; Norbert, Mbabi Nyemeck Ii; Florence, Moni Ndedi Esther Del; Hervé, Betote Diboué Patrick; Ascension, Nyegue Maximilienne; Théodore, Atchadé Alex De; Emmanuel, Pegnyemb Dieudonné; G, Bochet Christian; Koert, Ulrich

doi:10.1080/14786419.2017.1356832

Cited by 7 publications

(3 citation statements)

References 18 publications

(16 reference statements)

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“…For significant antitubercular activity concerning the flavonoid classes, this can be explained by the presence of polyhydroxyl substitutions which might produce remarkable improvements in antitubercular activity (Myricetin, 8) (MIC = 7.81 μg/mL), whereas the presence of methyl exemplified by 2'-hydroxy-4'-methoxyochnaflavone (2) (MIC = 62.5 μg/mL) or glycosidic residues in these substitution patterns may led to decreased activity against the test organism (compound 2 was 8 times less active than 8). The antimycobacterial activity detected for 1, 5, 6, 8 and 9 is in agreement to that previously reported (Erickson et al 2014;Ebeh Messanga et al 2017). According to Peterson and Shanholtzer (1992), bacteriostatic activity has been defined as a ratio of MBC to MIC of > 4.…”

Section: Evaluation Of Antimycobacterial Activitysupporting

confidence: 90%

Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis

Tiam

Bikobo

Zintchem

et al. 2017

Natural Product Research

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Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other known compounds. The chemical shifts of drypemolundein B (1) have been partially revised based on reinterpretation of NMR spectroscopic data. The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol (4), 3-O-β-D-glucopyranosylsitosterol (5), 3-O-β-D-glucopyranosylstigmasterol (6); oleanic acid (7); myricetin (8), quercetin (9) and 3-methoxyquercetin (10). Their structures were elucidated using IR, MS, NMR 1D and 2D, H andC and comparison with literature data. Furthermore, compounds 1, 2, 5, 6, 8, 9 and the crude extract were tested against Mycobacterium tuberculosis. Compounds 1, 2, 8 and 9 displayed moderate to very good activity against resistant strain (codified AC 45) of M. tuberculosis with minimum inhibitory concentrations MICs ranging from 3.90 to 62.5 μg/mL.

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Section: Evaluation Of Antimycobacterial Activitysupporting

confidence: 90%

Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis

Tiam

Bikobo

Zintchem

et al. 2017

Natural Product Research

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“…21,22 Oleanolic acid has also exhibited anti-tubercular activity. 23 The derivatives of oleanolic acid have been reported for the treatment of pancreatic cancer, 24 and oleanolic acid saponins have shown significant antimicrobial properties, 25 and the combination of oleanolic acid with hypocrellin A has been reported for the treatment of hepatocellular carcinoma diseases, 26 and oleanolic acid derivative SZC014 has exhibited anticancer activity. 27 Oleanolic acid has shown antidiabetic, 28,29 and hepatoprotective activities, 30,31 which may establish the use of H. umbellata as antidiabetic by the local inhabitants in Nigeria.…”

Section: Resultsmentioning

confidence: 99%

Isolation of Phytochemical Constituents from Hunteria umbellata K. Schum

Ali¹,

Falodun²,

Siyo³

et al. 2019

TJNPR

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Hunteria umbellata K. Schum has been reported for the treatment of diabetes in Nigeria. In the present study, the ethanolic extract of dried leaves of Hunteria umbellata K. Schum was investigated for the chemical principles. The isolated pure compounds were characterized by NMR, IR and Mass spectral studies. Ursolic acid (1), oleanolic acid (2) and squalene (3) were the main constituents isolated from the extract.

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“…Its main components are the α- and β-amyrin triterpenes [ 41 ]. Pentacyclic triterpenoids isolated from Alstonia scholaris also have shown antibacterial activity [ 42 ]. A sitosterol glycosylated derivative was identified in Rauvolfia caffra and showed some activity against Mycobacterium tuberculosis [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Susceptibility of virulent and resistant Escherichia coli strains to non-polar and polar compounds identified in Microplumeria anomala

et al. 2020

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Background and Aim: Escherichia coli is one of the main pathogens responsible for veterinary and human infections, and it is associated with significant economic losses in the livestock, as it causes severe diseases to humans, particularly in children. For that reason, there is a need for introducing new drugs to treat E. coli diseases. The Brazilian species richness is a source of potential new antibacterial natural products. The study aimed at the biological and chemical investigation of the organic extract obtained from the stem of Microplumeria anomala (Apocynaceae), EB127, as it was identified as a potential source of new antibacterial compounds to be used in Veterinary. Materials and Methods: The antibacterial activity was evaluated by disk diffusion and microdilution assays; chromatography, nuclear magnetic resonance spectrometry, and mass spectrometry were used in the isolation and identification of compounds. Results: EB127 showed activity against E. coli ATCC25922, and against three E. coli strains that were isolated from frigarte's cloaca, named 31/1A, 35A, and 51A. Lupeol, 3-acetyl-11-oxo-β-amyrin, 3-acetyl-11-oxo-α-amyrin, sitosterol, stigmasterol, 3β,7α-dihydroxy-cholest-5-ene, 3β-hydroxy-cholest-5-en-7-one, and 3β-hydroxy-cholest-5,22-dien-7-one were identified in fraction Hex/CHCl3, while loganin, loganic acid, methylanomaline, and anomaline were all identified in EB127 and protocatechuic acid hexoside, ferulic acid, secoxyloganin, feruloylquinic acid, vanillic acid hexoside, protocatechuic acid-4-O-β-hexoside, and rosmarinic acid were tentatively identified in fraction 10%ACN/H2O. E. coli 51A (virulent/non-resistant) showed sensitivity to the antibacterial action of fraction Hex/CHCl3 which contains alkaloids, triterpenes, and steroids, while E. coli 35A (resistant/non-virulent) were more susceptible to 10%ACN/H2O, which contains iridoids as loganin and loganic acid, and glycosylated and non-glycosylated caffeic acids. Conclusion: Fraction 10%ACN/H2O is of interest in pursuing new drugs to treat resistant E. coli, in veterinary. All compounds were isolated from the plant for the first time and have shown potential as new antibacterial natural products from Amazon plants to be used in veterinary and human diseases.

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Rauvolfianine, a new antimycobacterial glyceroglycolipid and other constituents from Rauvolfia caffra. Sond (Apocynaceae)

Cited by 7 publications

References 18 publications

Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis

Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis

Isolation of Phytochemical Constituents from Hunteria umbellata K. Schum

Susceptibility of virulent and resistant Escherichia coli strains to non-polar and polar compounds identified in Microplumeria anomala

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