Rats bred for helplessness exhibit positive reinforcement learning deficits which are not alleviated by an antidepressant dose of the MAO-B inhibitor deprenyl

Schulz, Daniela; Henn, Fritz A.; Petri, David; Huston, Joseph P.

doi:10.1016/j.neuroscience.2016.04.049

Cited by 6 publications

(4 citation statements)

References 50 publications

(76 reference statements)

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“…In the present study, cH rats were exposed to helplessness tests only because impairments are present in this strain even without prior exposure to uncontrollable stress (12)(13)(14). Test 1 was conducted as a baseline test.…”

Section: Methodsmentioning

confidence: 99%

“…Specifically, we compared the efficacy of the tricyclic antidepressant imipramine and the monoamine oxidase (MAO) inhibitor deprenyl across seasons in a congenital rat model of depression. model is based on selective breeding of rats that exhibit a helpless phenotype in a behavioral paradigm (11)(12)(13)(14). We hypothesized that both imipramine and deprenyl show a seasonal variation with regard to their efficacy in attenuating helplessness.…”

Section: Introductionmentioning

confidence: 99%

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Seasonal effects of the monoamine oxidase inhibitor deprenyl but not the tricyclic antidepressant imipramine in rats bred for helplessness

Schulz

2016

Med Sci and Discov

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Objective: Seasonal variations in monoaminergic function may underlie seasonal affective disorder, a subtype of major depression. Here, we examined whether antidepressant drugs which regulate monoaminergic function exhibit seasonal effects in an animal model of depression, congenital helplessness. Material and Method: Rats selectively bred for helplessness were required to press a lever to turn off a footshock before and after chronic treatment with the tricyclic antidepressant imipramine (10 mg/kg) or the monoamine oxidase inhibitor deprenyl (10 mg/kg). Control rats received saline. Different groups of rats were tested in summer-fall and spring over the course of two years. Results: Congenitally helpless (cH) rats that were treated with imipramine pressed the lever more often than controls in fall and in spring, indicative of antidepressant effects regardless of season. By contrast, cH rats treated with deprenyl pressed the lever more often in summer-fall than in spring, suggestive of seasonal drug effects on helplessness behavior. Deprenyl significantly attenuated the lever-pressing deficit in both seasons when compared to saline controls. Moreover, cH rats treated with deprenyl but not imipramine increased the number of lever presses over trials, indicative of negative reinforcement learning. Conclusion: The present data are the first to show seasonal variations in antidepressant drug effects that are possibly linked to changes in dopamine neurotransmission. The data support the view that we must take seasonality into account when evaluating the efficacy of antidepressant compounds.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Seasonal effects of the monoamine oxidase inhibitor deprenyl but not the tricyclic antidepressant imipramine in rats bred for helplessness

Schulz

2016

Med Sci and Discov

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“…Autoshaping clearly demonstrated that reinforcement was not necessary to explain the development of the canonical lever press response. Today, however, now nearly 80 years since Skinner's first Operant conditioning publications, positive reinforcement continues to be used to describe how a rat learns to press a lever [4][5][6][7][8][9]. If the stimulus was a reinforcer, it will increase the previous behavior.…”

Section: Articlementioning

confidence: 99%

Is Positive Reinforcement Pseudoscience?

Newquist¹

2017

ARC Journal of Neuroscience

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“…The factors, which influence the dynamics of this process, are still being actively discussed in the scientific community [2]. Thus, on the issue of the central dopamine participation there are data on the suppression of motion activity [3], as well as its stimulation [4], or even on the absence of the obvious effect [5]. The presence of antidepressant and anxiolytic effects is observed [3,6], as well as the grooming stimulation [7,8], or, on the contrary, the absence of meaningful psycho-emotional behavioral reactions [9].…”

Section: Introductionmentioning

confidence: 99%

Participation of dopaminergic system in the dynamics of behavioral reactions of aging rats of both sexes under daily testing in the open field

et al. 2021

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Under daily testing of aging rats of both sexes in the open field a slow lowering of motion activity is observed: by the 6th day of the experiment the passed distance of male rats reduces by 41% (р≤0.01), and of female rats – by 46% (р≤0.05) in comparison to the background values. The blockade of monoamine oxidase-B (МАО-В) by selegiline (intraperitoneal Introduction of 5 mg/kg one hour before testing) does not significantly change the orientation and intensity of this process, but probably contribute to the formation of a more comfortable psycho-emotional state of the animals. Consequently, the central dopamine cannot prevent from the motion activity lowering process of aging rats under daily testing, at least, in the frames of the experiment method used in this research. We obtained the evidence in favor of the fact that the suppression of the motion activity under daily testing is rather connected with the animals’ loss of motivation for research than with the growing anxiety.

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Rats bred for helplessness exhibit positive reinforcement learning deficits which are not alleviated by an antidepressant dose of the MAO-B inhibitor deprenyl

Cited by 6 publications

References 50 publications

Seasonal effects of the monoamine oxidase inhibitor deprenyl but not the tricyclic antidepressant imipramine in rats bred for helplessness

Seasonal effects of the monoamine oxidase inhibitor deprenyl but not the tricyclic antidepressant imipramine in rats bred for helplessness

Is Positive Reinforcement Pseudoscience?

Participation of dopaminergic system in the dynamics of behavioral reactions of aging rats of both sexes under daily testing in the open field

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