Abstract:Objective: Seasonal variations in monoaminergic function may underlie seasonal affective disorder, a subtype of major depression. Here, we examined whether antidepressant drugs which regulate monoaminergic function exhibit seasonal effects in an animal model of depression, congenital helplessness. Material and Method: Rats selectively bred for helplessness were required to press a lever to turn off a footshock before and after chronic treatment with the tricyclic antidepressant imipramine (10 mg/kg) or the mon… Show more
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