Rationale, secondary outcome scores and 1-year follow-up of a randomised trial of platelet-rich plasma injections in acute hamstring muscle injury: the Dutch Hamstring Injection Therapy study

Abstract

At 1-year postinjection, we found no benefit of intramuscular PRP compared with placebo injections in patients with acute hamstring injuries in the time to return to play, re-injury rate and alterations of subjective, clinical or MRI measures.

Actovegin Equals to Performance Enhancing Drug Doping: Fact or Fiction?

“…Interventions such as Platelet Rich Plasma (PRP) and Autologous Conditioning Serum (ACS) have become popular augmentative therapies in Sports Medicine, being proposed to facilitate muscle healing by optimizing provision of growth factors from promising animal study [13][14][15]. However, again these results do not necessarily translate to human trial.…”

“…However, again these results do not necessarily translate to human trial. Reurink et al in a recent, double-blind, randomized placebo controlled trial, showed no clinical or statistical difference between PRP and placebo treated groups [15]. This study did highlight the heterogeneity in PRP preparation protocol, distinct lack of consistency in quality control and thus, variation between individual PRP injections.…”

Effectiveness of PRP Injection in Reducing Recovery Time of Acute Hamstring Injury: A Critically Appraised Topic

“…Two articles showed no benefit of PRP injection in combination with rehabilitation compared to rehabilitation alone (Total N=170). [9][10][11] One study (N=28), however, demonstrated that PRP injections combined with a rehabilitation program allowed significantly higher levels of pain relief, faster regeneration, and shorter recovery time following an acute hamstring injury than rehabilitation alone. 1 It is important to note that in this study, the control group demonstrated a very large standard deviation for time to return to play (42.5 days + 20.6 vs. 26.7 days + 7.0 for the PRP group).…”

“…One study used a placebo saline injection in the comparison group. 8,9  All three studies included participants with acute hamstring injuries 1,[9][10][11] . Two studies [9][10][11] included both Grade I and II hamstring injury, while one 1 included only grade 2a hamstring injury.…”

Autologous Platelet Rich Plasma for Neck and Lower Back Pain Secondary to Spinal Disc Herniation: Midterm Results

“…Platelet-rich plasma is an orthobiologic that has recently gained popularity as an adjuvant treatment for musculoskeletal injuries [10][11][12][13][14][15][16][17][18]. It is a volume of fractionated plasma from the patient's own blood that contains platelet concentrate.…”