Rational design of a novel MOF-based ternary nanocomposite for effectively monitoring harmful organophosphates in foods and the environment

Wu, Fang; Wang, Beibei; Guo, Haiqian; Kang, Kai; Ji, Xueping; Wang, Lanyue; Guo, Shouxiang; Ren, Jianguo

doi:10.1039/d2ay01893d

Cited by 5 publications

(4 citation statements)

References 45 publications

(65 reference statements)

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“…As far as we know, Zn-MOF stands out as the first MOF that can be employed as a potentially effective fluorescent sensor for detecting PBP at a nanomolar scale, which is a widely used BFR. A comparative list of MOFs demonstrating similar sensing capabilities is presented in Table S7 of the SI. , …”

Section: Resultsmentioning

confidence: 99%

“…A comparative list of MOFs demonstrating similar sensing capabilities is presented in Table S7 of the SI. 10,67 Additionally, to assess the specificity and selectivity of Zn-MOF toward the investigated flame retardants, the detection selectivity of Zn-MOF for PBP and TBPA with the existence of other potential interfering flame retardants is explored. For this, a 2 mL suspension of Zn-MOF is primarily added to 70 μL (10 mM) of respective flame retardants, for instance, PBP and TBPA, followed by the addition of 70 μL (10 mM) of other potentially competing flame retardants (apart from PBP and TBPA) and their interference with PBP and TBPA is observed (Figure S27).…”

Section: Inorganicmentioning

confidence: 99%

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Zinc(II)-MOF: A Versatile Luminescent Sensor for Selective Molecular Recognition of Flame Retardants and Antibiotics

Rani,

Husain,

Bhasin

et al. 2024

Inorg. Chem.

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An exceptional Zinc(II)-organic framework with the formula [{Zn(L 4-py )(bdc)}•DMF] n (Zn-MOF) has been constructed solvothermally using a novel linker L 4-py {2,7-bis(3-(pyridin-4-ylethynyl)phenyl)benzo [lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone}, coligand H 2 bdc (1,4-benzenedicarboxylic acid), and ZnBF 4 •xH 2 O. The ligand L 4-py has been fabricated after functionalization of NDA (1,4,5,8-naphthalenetetracarboxylic dianhydride) core with 3-(pyridin-4-ylethynyl)phenyl group. The single-crystal X-ray analysis reveals that Zn-MOF exhibits a comprehensive three-dimensional (3D) framework architecture and features (4)-connected uninodal dia; 4/6/c1; sqc6 topology with point symbol {6 6 } and two-dimensional (2D) + 2D, parallel polycatenation. Notably, Zn-MOF displayed excellent fluorescence phenomenon and stability in water as well as in methanol solvents and was harnessed as a versatile sensor, demonstrating selective and sensitive molecular recognition of flame retardants and antibiotics. Notably, Zn-MOF displayed 57 and 49.5% quenching efficiency for the flame-retardant pentabromophenol (PBP) and 3,3′,5,5′-tetrabromobisphenol A (TBPA), respectively. Whereas an outstanding 90% quenching efficiency was observed for antibiotics, tetracycline (TC) and secnidazole (SD). The mechanistic investigations of this luminescence quenching suggest that this might be primarily occurring via the Fourier resonance energy transfer (FRET) and photoinduced electron transfer (PET) mechanisms, which might be assisted by the competitive absorption and host−guest interactions. The π-electron-rich framework structure of sensor Zn-MOF activates this mechanism.

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Section: Resultsmentioning

confidence: 99%

Section: Inorganicmentioning

confidence: 99%

Zinc(II)-MOF: A Versatile Luminescent Sensor for Selective Molecular Recognition of Flame Retardants and Antibiotics

Rani,

Husain,

Bhasin

et al. 2024

Inorg. Chem.

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“…Prussian blue [83], Co phthalocyanine [84], 7,7,8,8tetracyanoquinodimethane (TCNQ) [85], macrocycles bearing hydroquinone units [74,86,87] and metal-organic framework (MOF) particles [88,89] are implemented in the surface layer together with enzyme molecules. Mediators are often combined with each other and carbon nanomaterials.…”

Section: Cholinesterase Biosensor Signal Measurementmentioning

confidence: 99%

“…Thiocholine can be directly oxidized to disulfide on carbon electrodes at about 0.6 V. Mediated oxidation is preferred to avoid the passivation of the electrode and to decrease the overpotential of the reaction. For this purpose, Ag [74,[78][79][80] and Au nanoparticles [68,69,81,82], Prussian blue [83], Co phthalocyanine [84], 7,7,8,8-tetracyanoquinodimethane (TCNQ) [85], macrocycles bearing hydroquinone units [74,86,87] and metal-organic framework (MOF) particles [88,89] are implemented in the surface layer together with enzyme molecules. Mediators are often combined with each other and carbon nanomaterials.…”

Section: Cholinesterase Biosensor Signal Measurementmentioning

confidence: 99%

Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer’s Disease Drug Determination

Ivanov,

Shamagsumova,

Larina

et al. 2024

Biosensors

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Neurodegenerative diseases and Alzheimer’s disease (AD), as one of the most common causes of dementia, result in progressive losses of cholinergic neurons and a reduction in the presynaptic markers of the cholinergic system. These consequences can be compensated by the inhibition of acetylcholinesterase (AChE) followed by a decrease in the rate of acetylcholine hydrolysis. For this reason, anticholinesterase drugs with reversible inhibition effects are applied for the administration of neurodegenerative diseases. Their overdosage, variation in efficiency and recommendation of an individual daily dose require simple and reliable measurement devices capable of the assessment of the drug concentration in biological fluids and medications. In this review, the performance of electrochemical biosensors utilizing immobilized cholinesterases is considered to show their advantages and drawbacks in the determination of anticholinesterase drugs. In addition, common drugs applied in treating neurodegenerative diseases are briefly characterized. The immobilization of enzymes, nature of the signal recorded and its dependence on the transducer modification are considered and the analytical characteristics of appropriate biosensors are summarized for donepezil, huperzine A, rivastigmine, eserine and galantamine as common anti-dementia drugs. Finally, the prospects for the application of AChE-based biosensors in clinical practice are discussed.

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Metal-organic framework-based nanoarchitectonics: A promising material platform for electrochemical detection of organophosphorus pesticides

Huang,

Wu,

et al. 2024

Coordination Chemistry Reviews

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Rational design of a novel MOF-based ternary nanocomposite for effectively monitoring harmful organophosphates in foods and the environment

Abstract: Methyl parathion (MP) is a widely used organophosphate insecticide that is extremely toxic due to its ability to irreversibly inhibit acetylcholinesterase in the body and persistently accumulate in the environment....

Cited by 5 publications

References 45 publications

Zinc(II)-MOF: A Versatile Luminescent Sensor for Selective Molecular Recognition of Flame Retardants and Antibiotics

Zinc(II)-MOF: A Versatile Luminescent Sensor for Selective Molecular Recognition of Flame Retardants and Antibiotics

Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer’s Disease Drug Determination

Metal-organic framework-based nanoarchitectonics: A promising material platform for electrochemical detection of organophosphorus pesticides

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