Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer’s Disease Drug Determination
Alexey Ivanov,
Rezeda Shamagsumova,
Marina Larina
et al.
Abstract:Neurodegenerative diseases and Alzheimer’s disease (AD), as one of the most common causes of dementia, result in progressive losses of cholinergic neurons and a reduction in the presynaptic markers of the cholinergic system. These consequences can be compensated by the inhibition of acetylcholinesterase (AChE) followed by a decrease in the rate of acetylcholine hydrolysis. For this reason, anticholinesterase drugs with reversible inhibition effects are applied for the administration of neurodegenerative diseas… Show more
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