Rational Design of a Dual‐Reactivity‐Based Fluorescent Probe for Visualizing Intracellular HSNO

Abstract

Sendai 980-8575 (Japan) Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

A novel fluorescent probe for real-time imaging of thionitrous acid under inflammatory and oxidative conditions

“…The stock solution of Angeli's salt were prepared in degassed 10 mM NaOH solution containing 50 μM diethylenetriaminepentaacetic acid (DTPA). The stock solution of HSNO (300 μM) was freshly prepared by mixing 1 mM GSNO and 300 μM Na 2 S in 50 mM PBS [ 23 ]. The stock solution of SNP-1 was prepared in DMSO.…”

“…Analysis of some HSNO-relevant reactions revealed that HSNO has sulfane sulfur character and performs trans -nitrosation, similar to other RSNO compounds [ 22 ]. This preliminary information on the dual reactivity of HSNO enabled the development of a fluorescent probe (TAP-1) for HSNO detection [ 23 ]. TAP-1 is very sensitive and specific to the presence of HSNO, and it demonstrated effectiveness for visualizing cellular HSNO formation in HEK293 cells.…”

N-alkyl functionalized squaraine dyes as fluorescent probes for the detection of serum albumins

“…There are many fluorescent dyes with different structures, which can be successfully used for the detection and visualization of various biomolecules [1][2][3][4][5]. Squaraine (SQ) dyes are a class of organic dyes derived from the aromatic squaric acid core and containing electron-donating aromatic rings at the diametrically opposite sides of the four-member ring.…”

Synthesis of some new distyrylbenzene derivatives using immobilized Pd on an NHC-functionalized MIL-101(Cr) catalyst: photophysical property evaluation, DFT and TD-DFT calculations

“…The synthesis of uorescent compounds to be used in organic light emitting diodes (OLEDs), [1][2][3][4][5] solar cells, 6,7 organic eld effect transistors (OFETs), 8,9 sensing, [10][11][12] and uorescent probes [13][14][15][16] is highly considered. Stilbene compounds are a signicant class of uorescent organic p-conjugated compounds, which are widely used in the above mentioned applications.…”