Ratiometric detection of amyloid-β aggregation by a dual-emissive tris-heteroleptic ruthenium complex

Shao, Jiang‐Yang; Wu, Si‐Hai; Ma, Junjie; Gong, Zhong‐Liang; Sun, Tian-Ge; Jin, Yulong; Yang, Rong; Sun, Bin; Zhong, Yu‐Wu

doi:10.1039/c9cc08909h

Cited by 21 publications

(21 citation statements)

References 39 publications

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“…Complex 12 2+ is another dual‐emissive ruthenium complex that contains three different bidentate ligands. [ 32 ] The use of the N , N ‐di(pyrid‐2‐yl)‐methylamine ligand induces the dual‐emission property. The use of the dipyrido[3,2‐a:2′,3′‐c]phenazine (dppz) ligand allows the complex to interact with protein or DNA.…”

Section: Stimuli‐responsive Luminescent Metal Complexesmentioning

confidence: 99%

Photofunction‐Directed Coordination Molecular Engineering

Zhong

2021

Chin. J. Chem.

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Molecular engineering has emerged as a highly interdisciplinary field of study on function‐directed molecular design, material synthesis, and property optimization, accompanied by a deep understanding of the structure‐property relationship. In this review, our recent progress on the design and preparations of photofunctional metal complexes and related materials is summarized from the perspective of coordination molecular engineering. In particular, a series of cyclometalated diruthenium complexes with near‐infrared (NIR) electrochromic property have been synthesized by engineering the bridging ligand structures. A group of ruthenium‐amine conjugated complexes with multistage NIR electrochromism are obtained on the basis of a multicenter strategy. By engineering the ligand structures, a series of new ruthenium and platinum complexes are synthesized to show switchable luminescence in response to various stimuli. In addition, photoluminescent ruthenium, iridium, and platinum complexes are assembled to afford micro/nanocrystals with well‐defined morphology and luminescent properties. What is the most favorite and original chemistry developed in your research group? Ruthenium‐triarylamine conjugated system is one of my favorite topics. How do you get into this specific field? Molecular materials with multistage redox processes and multiple near‐ infrared absorptions are a challenging task in the field of electrochromism and molecular switching. The combination of cyclometalated ruthenium complexes and triarylamines allows us to solve this issue by using a multicenter strategy with a great structural and functional diversity. What is the most important personality for scientific research? Personally, I consider honesty, curiosity, and persistence are the most important and fundamental personalities in carrying out scientific research. What's your hobbies? I enjoy playing basketball and watching basketball matches in leisure time. How do you keep balance between research and family? I like managing time by prioritizing daily tasks. If time permits, I'm glad to join family activities in cooking, walking, exercising, etc. I always appreciate and support my wife's career and my daughter's studies, from which I receive their returns in support of my career. Could you please give us some advices on improving Chinese Journal of Chemistry? Chin. J. Chem. is a classical and influential journal of chemistry. The impact of the journal keeps increasing especially in recent years. In my point of view, it would be helpful for the journal by keeping a balance among different subjects of chemistry while welcoming manuscripts on material and energy‐related interdisciplinary researches. In addition, in order to further boost its global reputation, I would like to suggest inviting more international scientists to contribute to the journal.

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Section: Stimuli‐responsive Luminescent Metal Complexesmentioning

confidence: 99%

Photofunction‐Directed Coordination Molecular Engineering

Zhong

2021

Chin. J. Chem.

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“…These parameters can be influenced by different factors including the microenvironment, probe concentration, and the excitation energy. To improve the detection of Aβ aggregates, Zhong group used a ratiometric photoluminescent probe with two distinct emission bands [77] . Here, a tris‐heteroleptic ruthenium complex with three different bidentate ligands was used ([Ru(phen)(dpma)(dppz)] 2+ , where dpma= N , N ‐di(pyrid‐2‐yl)‐methylamine, Figure 2, 9 ).…”

Section: Ruthenium(ii) Metal Complexesmentioning

confidence: 99%

Probing Amyloid Nanostructures Using Photoluminescent Metal Complexes

Jiang

Martí

2021

Eur J Inorg Chem

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Amyloid aggregates have been linked to the onset of multiple human neurodegenerative diseases, including Alzheimer's disease, Parkinson disease and type II diabetes. The detection of these aggregates is critical for understanding the mechanism and factors that lead to aggregation. In the recent decades, photoluminescence spectroscopy has been utilized to study amyloid aggregation, allowing the development of interesting therapeutic and diagnostic strategies. With the advancement of photoluminescence spectroscopy, metal complexes have led to the detection of amyloid aggregates due to their distinct properties. In the presence of amyloid aggregates, these metal complexes exhibit specific responses such as intensity changes, shift in emission wavelength, variations in lifetime and anisotropy changes. In this minireview, we provide an overview of the photoluminescent metal complexes used for the detection of amyloid aggregates, including Ru(II), Re(I), Ir(III) and Pt(II) complexes.

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“…[ 9–11 ] However, very few ratiometric fluorescent probes for Aβ recognition have been reported. [ 12–15 ] On the other hand, a variety of approaches to inhibit Aβ aggregation have been developed, [ 16 ] such as small molecules, [ 17–22 ] polymers, [ 23–25 ] peptides, [ 26–27 ] nanomaterials, [ 28–34 ] nanocomposites, [ 35–37 ] which functioned mainly by noncovalent interactions, including electrostatic interactions, π‐π stacking, hydrogen bonding, and hydrophobic interactions. These interactions are unstable and sensitive to interferences, such as temperature or pH.…”

Section: Introductionmentioning

confidence: 99%

A Ratiometric Fluorescent Conjugated Oligomer for Amyloid β Recognition, Aggregation Inhibition, and Detoxification

Zhang

Yuan

et al. 2021

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The sensitive recognition and effective inhibition of toxic amyloid β protein (Aβ) aggregates play a critical role in early diagnosis and treatment of neurodegenerative diseases. In this work, a new conjugated oligo(fluorene‐co‐phenylene) (OFP) modified with 1,8‐naphthalimide (NA) derivative OFP‐NA‐NO2 is designed and synthesized as a ratiometric fluorescence probe for sensing Aβ, inhibiting the assembly of Aβ, and detoxicating the cytotoxicity of Aβ aggregates. In the presence of Aβ, the active ester group on the side chain of OFP‐NA‐NO2 can covalently react with the amino group on Aβ, effectively inhibiting the formation of Aβ aggregates and degrading the preformed fibrils. In this case, the fluorescence intensity ratio of NA to OFP (INA/IOFP) increases greatly. The detection limit is calculated to be 89.9 nM, presenting the most sensitive ratiometric recognition of Aβ. Interestingly, OFP‐NA‐NO2 can dramatically recover the cell viability of PC‐12 and restore the Aβ‐clearing ability of microglia. Therefore, this ratiometric probe exhibits the targeted recognition of Aβ, effective inhibition of Aβ aggregates, and detox effect, which is potential for early diagnosis and treatment of neurodegenerative diseases.

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Ratiometric detection of amyloid-β aggregation by a dual-emissive tris-heteroleptic ruthenium complex

Abstract: A dual-emissive tris-heteroleptic ruthenium complex is reported for the ratiometric photoluminescent detection of amyloid-β aggregation in steady and transient states.

Cited by 21 publications

References 39 publications

Photofunction‐Directed Coordination Molecular Engineering

Photofunction‐Directed Coordination Molecular Engineering

Probing Amyloid Nanostructures Using Photoluminescent Metal Complexes

A Ratiometric Fluorescent Conjugated Oligomer for Amyloid β Recognition, Aggregation Inhibition, and Detoxification

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