Ratio of C-reactive protein to albumin is a prognostic factor for operable non-small-cell lung cancer in elderly patients

Miyazaki, Takuro; Yamasaki, Naoya; Tsuchiya, Tomoshi; Matsumoto, Keitaro; Kitajima, Masaki; Kamohara, Ryotaro; Hatachi, Go; Doi, Ryoichiro; Obata, Tomohiro; Nagayasu, Takeshi

doi:10.1007/s00595-016-1448-8

Cited by 35 publications

(25 citation statements)

References 24 publications

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“…HRs with 95% CIs were directly obtained from the articles or estimated from the K-M curves according to the methods reported by Tierney et al [19] Statistical heterogeneity among the studies was evaluated with Q and I 2 statistics, with the significance level set at P < .05. [20] If there was significant heterogeneity among the studies, a random effects model was used to calculate the pooled HRs and 95% CIs. [21] Sensitivity analyses to rule out overrepresentation of results from a single study in the meta-analysis were performed by excluding each study individually from the meta-analysis.…”

Section: Methodsmentioning

confidence: 99%

The prognostic value of C-reactive protein to albumin ratio in patients with lung cancer

et al. 2018

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Background:To perform a meta-analysis of retrospective studies exploring the association of C-reactive protein to albumin (CAR) with overall survival (OS) in patients with lung cancer.Methods:Relevant studies were enrolled by searching databases of PubMed, Cochrane Library, Web of Science, and Embase were searched until July 16, 2017. We combined the hazard ratios (HRs) and 95% confidence intervals (CIs) to assess the correlation between CAR and OS in patients with lung cancerResults:Four studies involving 1257 participants from several countries were involved in the meta-analysis. In a pooled analysis of all studies, elevated CAR predicted poor OS (HR: 2.13; 95% CI: 1.52–2.97; P < .05). Subgroup analysis showed that high level of CAR predicted poor OS in patients with lung cancer though multivariate analyses on 1092 participants (HR: 1.63; 95% CI: 1.24–2.51; P < .001) and the heterogeneity decreased to 45.4%. Moreover, a similar trend was observed in patients receiving surgery (HR: 2.64; 95% CI: 2.08–3.35; P < .001) and chemotherapy (HR: 1.75; 95% CI: 1.93–2.57; P = .004). And the HRs for patients receiving surgery was moderately higher than that for patients receiving chemotherapy.Conclusion:Our findings indicate that CAR may have a prognostic value in lung cancer as we detected a significant association between elevated CAR and poorer OS. However, further studies are warranted to draw firm conclusions.

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Section: Methodsmentioning

confidence: 99%

The prognostic value of C-reactive protein to albumin ratio in patients with lung cancer

et al. 2018

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“…Appropriate patient selection is also important when undertaking multimodal therapy. Many recent reports have described the use of prognostic factors involving inflammatory markers such as combinations of neutrophils, platelets, and lymphocytes; 1,2) the C-reactive protein level; and the nutritional status as indicated by the serum albumin and cholesterol levels 15) in both lung cancer 16,17) and MPM although the cutoff values have not been fully investigated. The EORTC prognostic score 13) has also been assessed.…”

Section: Discussionmentioning

confidence: 99%

“…Cancer progression simultaneously induces the release of proinflammatory cytokines and promotes the immunovascular system, and neutrophils, lymphocytes, platelets, albumin, and C-reactive protein are affected. 16,17) The detailed mechanism and clinical significance of the inflammatory response have been fully described elsewhere. 15,18) In the present study, only the PLR and EORTC prognostic score were identified as prognostic factors in the univariate analysis.…”

Section: Discussionmentioning

confidence: 99%

Is Pleurectomy/Decortication Superior to Extrapleural Pneumonectomy for Patients with Malignant Pleural Mesothelioma? A Single-Institutional Experience

Miyazaki

Yamasaki

Tsuchiya

et al. 2018

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“…The CONUT score was defined based on the total scores for these points. PNI was calculated as 10×the serum albumin level (g/dl)+0.005 × the absolute lymphocyte count (14).CAR was calculated as the ratio of serum CRP (mg/dl) to serum albumin (g/dl) (15). NLR was calculated as the absolute neutrophil count divided by the absolute lymphocyte count (4).…”

Section: Methodsmentioning

confidence: 99%

Comparative Analysis of Immunoinflammatory and Nutritional Measures in Surgically Resected Esophageal Cancer: A Single-center Retrospective Study

Sakai

Sohda

Saya

et al. 2020

In Vivo

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Background/Aim: Several immunoinflammatory and nutritional measures have been reported to be good prognostic indicators for esophageal cancer (EC). However, the association between those markers and the postoperative survival of EC patients remains unclear due to varying study designs and treatment strategies. The aim of this study was to compare the significance of preoperative immunoinflammatory and nutritional measures in patients with EC. Patients and Methods: One hundred and five patients with EC who underwent McKeown esophagectomy with gastric tube reconstruction without neoadjuvant therapy between 2006 and 2014 were included in this study. The prognostic values of preoperative modified Glasgow prognostic score (mGPS), controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), C-reactive protein (CRP)-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were investigated using univariate and multivariate survival analyses. Results: Multivariate analysis revealed that CAR and pathological stage are independent prognostic factors for overall survival (OS). CAR was significantly associated with more advanced pathological stage as both a subject and a continuous variable. Conclusion: Preoperative CAR was an independent prognostic factor for the OS of EC patients who underwent McKeown esophagectomy. The tumor-stage related increase in CAR demonstrated that a high CAR is associated with tumor progression in EC patients.

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Ratio of C-reactive protein to albumin is a prognostic factor for operable non-small-cell lung cancer in elderly patients

Abstract: The preoperative CAR is a useful predictor of overall survival and could be a simple prognostic tool to help identify resectable NSCLC in elderly patients.

Cited by 35 publications

References 24 publications

The prognostic value of C-reactive protein to albumin ratio in patients with lung cancer

The prognostic value of C-reactive protein to albumin ratio in patients with lung cancer

Is Pleurectomy/Decortication Superior to Extrapleural Pneumonectomy for Patients with Malignant Pleural Mesothelioma? A Single-Institutional Experience

Comparative Analysis of Immunoinflammatory and Nutritional Measures in Surgically Resected Esophageal Cancer: A Single-center Retrospective Study

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