Is Pleurectomy/Decortication Superior to Extrapleural Pneumonectomy for Patients with Malignant Pleural Mesothelioma? A Single-Institutional Experience

Miyazaki, Takuro; Yamasaki, Naoya; Tsuchiya, Tomoshi; Matsumoto, Keitaro; Kamohara, Ryotaro; Hatachi, Go; Nagayasu, Takeshi

doi:10.5761/atcs.oa.17-00192

Cited by 10 publications

(3 citation statements)

References 23 publications

(32 reference statements)

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“…To date, two major surgical procedures are available for removal or debulking of MPM that is considered to be resectable: [extended (e)] pleurectomy/decortication (P/D) and extrapleural pneumonectomy (EPP), but this is subject to discussion, in particular regarding the most appropriate intervention (5,(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Extrapleural pneumonectomy: still indicated?

Domen

Berzenji

Hendriks

et al. 2018

Transl. Lung Cancer Res

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The optimal treatment of malignant pleural mesothelioma (MPM) has not yet been established and is still under investigation. Surgery is one of the pillars in the multimodality approach with the purpose of removing as much as visible tumor as possible and to relieve symptoms. To date, two major surgical procedures are available for removal or debulking of MPM that is considered to be resectable: [extended (e)] pleurectomy/decortication (P/D) and extrapleural pneumonectomy (EPP). Historically, EPP was regarded as the only way to achieve a macroscopic complete resection. However, in the last years, there is a shift in literature towards (e)P/D as the preferred surgical procedure whenever possible as several retrospective studies and meta-analyses showed a similar or lower long-term survival and higher perioperative mortality and postoperative morbidity in patients who been treated with EPP. On the other hand, no randomizedcontrolled trials regarding surgical treatment with (e)P/D or EPP exist and therefore level A evidence favoring one surgical procedure is lacking. In this review we provide a nuanced and well-considered answer to the question whether EPP is still indicated in the surgical treatment of MPM.

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Section: Introductionmentioning

confidence: 99%

Extrapleural pneumonectomy: still indicated?

Domen

Berzenji

Hendriks

et al. 2018

Transl. Lung Cancer Res

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“…The primary indication of decortication is fibrothorax because of chronic empyema thoracis (pyogenic and tubercular), haemothorax and pleural thickening due to inflammatory conditions like rheumatoid arthritis and tumours like malignant mesothelioma. 1 , 2 Contraindications to decortication, as bronchial stenosis is an absolute contraindication to performing a decortication procedure. These patients additionally require resection of the stenosed segment and bronchial anastomosis apart from decortication of the severely diseased lung.…”

Section: Discussionmentioning

confidence: 99%

Lung decortication for spontaneous hydropneumothorax in post COVID patients: A case series

Kumar¹,

Mishra²

2022

Perioperative Care and Operating Room Management

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“…Although nonrandomized controlled trials comparing surgical treatment with extended-P/D or EPP exist, retrospective series favor extended-P/D (Table 1) [26][27][28][29][30][31][32][33][34][35][36][37][38]. A meta-analysis published by Cao et al compared EPP (n = 632) to extended-P/D (n = 513) from seven relevant studies [39].…”

Section: Surgical Resectionmentioning

confidence: 99%

Current Treatment Strategies in Malignant Pleural Mesothelioma with a Treatment Algorithm

Sayan

Eren

Gupta

et al. 2019

Advances in Respiratory Medicine

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Malignant pleural mesothelioma (MPM) is a rare disease with a poor prognosis. The main therapeutic options for MPM include surgery, chemotherapy, and radiation therapy (RT). Although multimodality therapy has been reported to improve survival, not every medically operable patient is able to undergo all recommended therapy. With improvements in surgical techniques and systemic therapies, as well as advancements in RT, there has been a potential new paradigm in the management of this disease. In this review, we discuss the current literature on MPM management and propose a functional treatment algorithm.

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Is Pleurectomy/Decortication Superior to Extrapleural Pneumonectomy for Patients with Malignant Pleural Mesothelioma? A Single-Institutional Experience

Cited by 10 publications

References 23 publications

Extrapleural pneumonectomy: still indicated?

Extrapleural pneumonectomy: still indicated?

Lung decortication for spontaneous hydropneumothorax in post COVID patients: A case series

Current Treatment Strategies in Malignant Pleural Mesothelioma with a Treatment Algorithm

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