Rates of RNFL Thinning in Patients with Suspected or Confirmed Glaucoma Receiving Unilateral Intravitreal Injections for Exudative AMD

Swaminathan, Swarup S.; Kunkler, Anne L.; Quan, Ann; Medert, Charles M.; Vanner, Elizabeth A.; Feuer, William J.; Chang, Ta Chen

doi:10.1016/j.ajo.2020.12.016

Cited by 9 publications

(7 citation statements)

References 48 publications

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“…Horsley et al18 reported no RNFL loss in a retrospective study of injected eyes that underwent RNFL measurement over the span of at least 1 year. Swaminathan et al23 reported no difference in RNFL thinning per year in a retrospective study of 53 injected eyes versus fellow eye controls. If there is an association between injections and RNFL loss, then it is likely that some but not all eyes are susceptible, and small studies might bias the data and miss susceptible eyes.…”

Section: Sequelae Of Postinjection Iop Elevation: Glaucoma and Retina...mentioning

confidence: 95%

“…Studies examining the effect of injections on RNFL architecture are summarized in Table 1. 8,[17][18][19][20][21][22][23][24] In their 2020 meta-analysis of intravitreal injections and RNFL stability, de Vries et al 8 included 4 studies on this topic and concluded that RNFL was significantly reduced by −3.34 µm at 1 year, but only 1 of the 4 individual studies (Martinez-de-la-Casa and colleagues) inferred that injections were associated with thinning. Martinez-de-la-Casa et al 20 completed a prospective study of 49 eyes and 17 control eyes that demonstrated RNFL thinning in injected eyes over the span of 1 year.…”

Section: Sequelae Of Postinjection Iop Elevation: Glaucoma and Retina...mentioning

confidence: 99%

“…Studies conflict on the topic of repeated injections on RNFL loss. Studies examining the effect of injections on RNFL architecture are summarized in Table 1 8,17–24. In their 2020 meta-analysis of intravitreal injections and RNFL stability, de Vries et al8 included 4 studies on this topic and concluded that RNFL was significantly reduced by −3.34 µm at 1 year, but only 1 of the 4 individual studies (Martinez-de-la-Casa and colleagues) inferred that injections were associated with thinning.…”

Section: Sequelae Of Postinjection Iop Elevation: Glaucoma and Retina...mentioning

confidence: 99%

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Intraocular Pressure Elevation Following Intravitreal Anti-VEGF Injections: Short- and Long-term Considerations

Levin

Chaya

Kahook³

et al. 2021

Journal of Glaucoma

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Published studies agree that transient intraocular pressure (IOP) spikes are common after intravitreal injections of anti–vascular endothelial growth factor agents. Currently, there is no standard of care guiding if and when to prevent these IOP spikes. Furthermore, there are challenges in determining the impact of postinjection IOP elevation on the health of the retinal ganglion cells, particularly given the often-existing comorbidities of retinal and glaucoma pathology. This review highlights the current literature regarding both acute and chronic postinjection IOP elevations and discusses management of postinjection IOP elevation, especially in patients at high risk for glaucomatous damage.

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Section: Sequelae Of Postinjection Iop Elevation: Glaucoma and Retina...mentioning

confidence: 95%

Section: Sequelae Of Postinjection Iop Elevation: Glaucoma and Retina...mentioning

confidence: 99%

Section: Sequelae Of Postinjection Iop Elevation: Glaucoma and Retina...mentioning

confidence: 99%

See 1 more Smart Citation

Intraocular Pressure Elevation Following Intravitreal Anti-VEGF Injections: Short- and Long-term Considerations

Levin

Chaya

Kahook³

et al. 2021

Journal of Glaucoma

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“…This model was applied if both eyes came from the same individual. 21 The root mean squared error (RMSE) for mVD and thickness measurements was calculated. Pearson correlation coefficients were used to evaluate the associations between VF measures with vascular and thickness measurements in POAG eyes.…”

Section: Discussionmentioning

confidence: 99%

“…These models included fixed effects for age, sex, group, and follow-up period. This model was applied if both eyes came from the same individual 21 . The root mean squared error (RMSE) for mVD and thickness measurements was calculated.…”

Section: Methodsmentioning

confidence: 99%

Progressive Macular Vessel Density Loss Observed on Optical Coherence Tomography Angiography in Glaucoma Patients With Single-Hemifield Visual Field Defects

Lin

Zhang

Shang

et al. 2023

Journal of Glaucoma

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Précis: Faster hemispheric mVD loss was found in the affected hemifield of POAG patients without significant changes in hemispheric thickness. The progression of mVD loss was associated with the severity of VF damage. Purpose: To evaluate the changes in macular vessel density (mVD) loss in primary open angle glaucoma (POAG) patients with visual field (VF) defects confined to 1 hemifield. Materials and Methods: This longitudinal cohort study used linear mixed models to evaluate the changes in the hemispheric mean total deviation (mTD), mVD, macular ganglion cell complex, macular ganglion cell-inner plexiform layer, and retinal nerve fiber layer between affected hemifields, unaffected hemifields, and healthy controls. Results: Twenty-nine POAG eyes and 25 healthy eyes were followed for an average of 29 months. In POAG eyes, the rates of decline in hemispheric mTD and hemispheric mVD in the affected hemifields were significantly faster than those in the unaffected hemifields (−0.42±1.24 vs. 0.02±0.69 dB/year, P=0.018 and −2.16±1.01 vs. −1.77±0.90% / year, P=0.031, respectively). There were no differences in the rate of hemispheric thickness change between the 2 hemifields. The rate of hemispheric mVD decline in both hemifields of POAG eyes was significantly faster than that of the healthy controls (All P<0.05). An association between the reduced mTD of the VF and the rate of hemispheric mVD loss in the affected hemifield was observed (r=0.484, P=0.008). Faster rates of mVD loss (β=−1.72±0.80, P =0.050) were significantly related to reduced hemispheric mTD in the multivariate analysis. Conclusions: Faster hemispheric mVD loss was found in the affected hemifield of POAG patients without significant changes in hemispheric thickness. The progression of mVD loss was associated with the severity of VF damage.

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Systemic and Ocular Adverse Events with Intravitreal Anti-VEGF Therapy Used in the Treatment of Diabetic Retinopathy: a Review

et al. 2022

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Rates of RNFL Thinning in Patients with Suspected or Confirmed Glaucoma Receiving Unilateral Intravitreal Injections for Exudative AMD

Cited by 9 publications

References 48 publications

Intraocular Pressure Elevation Following Intravitreal Anti-VEGF Injections: Short- and Long-term Considerations

Intraocular Pressure Elevation Following Intravitreal Anti-VEGF Injections: Short- and Long-term Considerations

Progressive Macular Vessel Density Loss Observed on Optical Coherence Tomography Angiography in Glaucoma Patients With Single-Hemifield Visual Field Defects

Systemic and Ocular Adverse Events with Intravitreal Anti-VEGF Therapy Used in the Treatment of Diabetic Retinopathy: a Review

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