Rates of hippocampal atrophy correlate with change in clinical status in aging and AD

Jack, Clifford R.; Petersen, Ronald C.; Xu, Yue; O’Brien, Peter C.; Smith, Glenn E.; Ivnik, Robert J.; Boeve, B. F.; Tangalos, Eric G.; Kokmen, Emre

doi:10.1212/wnl.55.4.484

Cited by 810 publications

(562 citation statements)

References 31 publications

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“…The HC plays an important role in human memory and orientation. Moreover, HC dysfunction is involved in a variety of diseases, including AD (Jack et al, 2000), posttraumatic stress disorder (Bremner et al, 1995), major depression (Bremner et al, 2000), schizophrenia (Buss et al, 2007;Tanskanen et al, 2005), and epilepsy (Bernasconi et al, 2003). This structure is especially difficult to segment because of its small size, high variability, low contrast, and discontinuous boundaries in MR images (Chupin et al, 2007;Siadat et al, 2007).…”

Section: Datasetsmentioning

confidence: 99%

Patch-based segmentation using expert priors: Application to hippocampus and ventricle segmentation

et al. 2011

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Section: Datasetsmentioning

confidence: 99%

Patch-based segmentation using expert priors: Application to hippocampus and ventricle segmentation

et al. 2011

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“…Neurodegeneration of the hippocampus is widely implicated in the loss of spatial memory (navigation skills), dementia, and AD (Foster 1999;Apostolova and Thompson 2007). In AD, the rate of hippocampal atrophy is 3.5-4%/year, exceeding the ∼1.6%/year loss observed in normal aging by nearly 3-fold (Jack et al 1998(Jack et al , 2000. For normal aging and neurodegenerative conditions alike, diminishing hippocampal volume is correlated with atrophy of other brain regions, increasing ventricular space and diminished brain volume (Scahill et al 2003;Apostolova and Thompson 2007).…”

Section: Brain Sizementioning

confidence: 99%

A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice

Aksenov

Long

Liu

et al. 2011

AGE

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We developed a complex dietary supplement designed to offset five key mechanisms of aging and tested its effectiveness in ameliorating age-related cognitive decline using a visually cued Morris water maze test. All younger mice (<1 year old) learned the task well. However, older untreated mice (>1 year) were unable to learn the maze even after 5 days, indicative of strong cognitive decline at older ages. In contrast, no cognitive decline was evident in older supplemented mice, even when ∼2 years old. Supplemented older mice were nearly 50% better at locating the platform than age-matched controls. Brain weights of supplemented mice were significantly greater than controls, even at younger ages. Reversal of cognitive decline in activity of complexes III and IV by supplementation was significantly associated with cognitive improvement, implicating energy supply as one possible mechanism. These results represent proof of principle that complex dietary supplements can provide powerful benefits for cognitive function and brain aging.

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“…The hippocampus plays a crucial role in cognitive processing associated with memory function (Tulving & Markowitsch, 1998), and accelerated atrophy of this region is an early feature of AD (Jack et al., 2000). Of particular interest is the relationship between hippocampal volume and episodic memory (Kramer et al., 2005; Mormino et al., 2009; Stoub, Rogalski, Leurgans, Bennett, & deToledo‐Morrell, 2010).…”

Section: Introductionmentioning

confidence: 99%

Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease

et al. 2017

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IntroductionCardiorespiratory fitness (CRF) has been shown to be related to brain health in older adults. In individuals at risk for developing Alzheimer's disease (AD), CRF may be a modifiable risk factor that could attenuate anticipated declines in brain volume and episodic memory. The objective of this study was to determine the association between CRF and both hippocampal volume and episodic memory in a cohort of cognitively healthy older adults with familial and/or genetic risk for Alzheimer's disease (AD).MethodsEighty‐six enrollees from the Wisconsin Registry for Alzheimer's Prevention participated in this study. Participants performed a graded maximal exercise test, underwent a T‐1 anatomical magnetic resonance imaging scan, and completed the Rey Auditory Verbal Learning Test (RAVLT).ResultsThere were no significant relationships between CRF and HV or RAVLT memory scores for the entire sample. When the sample was explored on the basis of gender, CRF was significantly associated with hippocampal volume for women. For men, significant positive associations were observed between CRF and RAVLT memory scores.SummaryThese results suggest that CRF may be protective against both hippocampal volume and episodic memory decline in older adults at risk for AD, but that the relationships may be gender specific.

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Rates of hippocampal atrophy correlate with change in clinical status in aging and AD

Abstract: Background-The cognitive continuum in the elderly population can be conceptually divided into those who are functioning normally (controls), those with a mild cognitive impairment (MCI), and those with probable AD.

Cited by 810 publications

References 31 publications

Patch-based segmentation using expert priors: Application to hippocampus and ventricle segmentation

Patch-based segmentation using expert priors: Application to hippocampus and ventricle segmentation

A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice

Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease

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