Rate of PSA rise predicts metastatic versus local recurrence after definitive radiotherapy

Defining biochemical cure for prostate carcinoma patients treated with external beam radiation therapy

“…Sartor et al 28 demonstrated a higher local failure rate with a longer half-life, which is somewhat contradictory to our results. Other studies have shown no relation between post-RT PSA half-life and treatment failure.…”

Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study

“…A short PSADT after definitive radiotherapy also predicts more rapid progression to symptoms. [15][16][17] The PSADT in men under observation alone has been shown to be the most powerful indicator of disease activity. 18 Although the use of PSADT to help predict those patients who will develop clinically progressive disease has been well established; it has not been established whether therapeutically altering or increasing the doubling time will impact the measurable clinical end points such as the development of metastatic disease or prolonged survival.…”

Detection of Local, Regional, and Distant Recurrence in Patients With PSA Relapse After External-Beam Radiotherapy Using 11C-Choline Positron Emission Tomography

“…Biochemical recurrence (BCR) following radiotherapy has been defined by the American Society for Therapeutic Radiology and Oncology (ASTRO) (1) and recently updated in the ASTRO Phoenix Consensus (2).The time interval between treatment and BCR as well as PSA doubling time are used as indicators for local or distant recurrence (3). Conventional imaging modalities such as CT and MRI are limited in their ability to localize the site of recurrence with high accuracy (4).…”