Defining biochemical cure for prostate carcinoma patients treated with external beam radiation therapy

Kestin, Larry L.; Vicini, Frank A.; Ziaja, Ellen L.; Stromberg, Jannifer S.; Frazier, Robert C.; Martínez, Álvaro

doi:10.1002/(sici)1097-0142(19991015)86:8<1557::aid-cncr24>3.0.co;2-2

Cited by 79 publications

(35 citation statements)

References 32 publications

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] In general, the lower the nPSA, the more favorable the result. The problem with using nPSA clinically is that unless there is evidence of a rising PSA, it is difficult to know when the nPSA has occurred.…”

Section: Discussionmentioning

confidence: 99%

“…T he nadir in prostate-specific antigen (nPSA) after radiotherapy (RT) has been shown to predict biochemical failure (BF), [1][2][3][4][5][6][7][8][9][10][11][12][13] distant metastasis (DM), 9,[13][14][15] cause-specific mortality (CSM), 14,15 and overall mortality (OM). 15 However, the nPSA usually takes several years to occur, even as long as 8-10 years in some cases.…”

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confidence: 99%

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Prostate‐specific antigen nadir within 12 months of prostate cancer radiotherapy predicts metastasis and death

Alçântara

Hanlon

Buyyounouski

et al. 2006

Cancer

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Objective: The main goal of this study was to verify the influence of low birth weight (LBW) on the physical fitness of children aged 7–10 years. The comparisons were subsequently adjusted for chronological age, gender, physical activity (PA), and body composition. Methods: A total of 356 children of both genders born in Vitoria de Santo Antão (Northeast of Brazil) were divided into two groups according to their birth weight (LBW < 2.500 g, n = 100, and normal birth weight, NBW ≥ 3.000 g and ≤ 3.999 g, n = 256). Body composition measurements included body weight, height, body mass index, triceps, and subscapular skinfolds, and body fat percentage (%BF). PA was assessed by a questionnaire. Physical fitness was assessed by handgrip strength, muscle endurance, explosive power, flexibility, agility, maximal oxygen consumption (VO2max), and running speed. Results: LBW children were shorter, lighter, had lower fat‐free mass, muscle strength, and running speed but a higher VO2max than the NBW group. The differences in body weight (P = 0.507), height (P = 0.177), fat‐free mass (P = 0.374), and VO2max (P = 0.312) disappeared when adjusted for covariates. The differences in right and left handgrip strength (P < 0.01) and running speed (P < 0.01) remained significant even when controlled for age, gender, height, fat‐free mass, and PA. Conclusion: This combined analysis suggests that LBW alone can be not considered as a biological determinant of growth, body composition, or physical fitness in children, but is a predictor of muscle strength and running speed. Am. J. Hum. Biol., 2013. © 2012 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Prostate‐specific antigen nadir within 12 months of prostate cancer radiotherapy predicts metastasis and death

Alçântara

Hanlon

Buyyounouski

et al. 2006

Cancer

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“…MRI-guided biopsy (D+E) was performed, and prostate cancer (Gleason score, 3+ 5) was demonstrated. Owing to the slice thickness of 4 mm of the T2w image, the throw of the 18G biopsy needle is blurred in image E regardless of whether serum PSA [66,67], digital rectal examination (DRE), or TRUS-guided biopsy is used to answer this question [68]. Detection of local prostate cancer recurrence is even more difficult with conventional MRI, as the low signal intensity of fibrotic changes after radiotherapy or of scar tissue after prostatectomy may mimic local recurrence on T2w images [5,6,69,70].…”

Section: Detection Of Recurrent Prostate Cancermentioning

confidence: 99%

Dynamic contrast-enhanced magnetic resonance imaging and pharmacokinetic models in prostate cancer

2010

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Dynamic contrast-enhanced MRI enables noninvasive analysis of prostate vascularization as well as tumour angiogenesis and capillary permeability characteristics in prostate cancers. Pharmacokinetic models summarizing the complex information provided by signal intensity-time curves for a few quantitative pharmacokinetic parameters are increasingly being used in the routine clinical setting. This review consists of two parts. The first part discusses the advantages and disadvantages of the MR pulse sequences that can be used for performing DCE-MRI and also of the most widely used pharmacokinetic parameters and models and the parameters they describe. The second part outlines the range of current and potential future clinical applications of DCE-MRI and pharmacokinetic parametric maps in patients with prostate cancer, with reference to the current scientific literature on the topic. The potential clinical applications of DCE-MRI for prostate cancer include detection, localization, and staging, differentiation of recurrent cancer and estimation of the patient's prognosis, as well as monitoring of treatment response.

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“…Yet, despite our best efforts in selecting appropriate therapy, up to 50% of these patients, depending on risk factors, will develop biochemical failure within 5 years, leaving room for improvement (1)(2)(3). Prostate cancer treatment options are numerous, and accurate prediction of patient outcome is an increasingly important guide for appropriate treatment of the disease.…”

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confidence: 99%

Prostate Cancer: Prediction of Biochemical Failure after External-Beam Radiation Therapy—Kattan Nomogram and Endorectal MR Imaging Estimation of Tumor Volume

et al. 2011

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Purpose:To determine whether magnetic resonance (MR) imaging and MR spectroscopic imaging fi ndings can improve predictions made with the Kattan nomogram for radiation therapy. Materials and Methods:The institutional review board approved this retrospective HIPAA-compliant study. Ninety-nine men who underwent endorectal MR and MR spectroscopy before externalbeam radiation therapy for prostate cancer (January 1998 to June 2007) were included. Linear predictors were calculated with input variables from the study sample and the Kattan original coeffi cients. The linear predictor is a single weighted value that combines information of all predictor variables in a model, where the weight of each value is its association with the outcome. Two radiologists independently reviewed all MR images to determine extent of disease; a third independent reader resolved discrepancies. Biochemical failure was defi ned as a serum prostate-specifi c antigen level of 2 ng/mL (2 m g/L) or more above nadir. Cox proportional hazard models were used to determine the probabilities of treatment failure (biochemical failure) in 5 years. One model included only the Kattan nomogram data; the other also incorporated imaging fi ndings. The discrimination performance of all models was determined with receiver operating characteristics (ROC) curve analyses. These analyses were followed by an assessment of net risk reclassifi cation. Results:The areas under the ROC curve for the Kattan nomogram and the model incorporating MR imaging fi ndings were 61.1% (95% confi dence interval: 58.1%, 64.0%) and 78.0% (95% confi dence interval: 75.7%, 80.4%), respectively . Comparison of performance showed that the model with imaging fi ndings performed signifi cantly better than did the model with clinical variables alone ( P , .001).Overall, the addition of imaging fi ndings led to an improvement in risk classifi cation of about 28%, ranging from approximately a minimum of 16% to a maximum of 39%, depending on the risk change considered important.

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Defining biochemical cure for prostate carcinoma patients treated with external beam radiation therapy

Cited by 79 publications

References 32 publications

Prostate‐specific antigen nadir within 12 months of prostate cancer radiotherapy predicts metastasis and death

Prostate‐specific antigen nadir within 12 months of prostate cancer radiotherapy predicts metastasis and death

Dynamic contrast-enhanced magnetic resonance imaging and pharmacokinetic models in prostate cancer

Prostate Cancer: Prediction of Biochemical Failure after External-Beam Radiation Therapy—Kattan Nomogram and Endorectal MR Imaging Estimation of Tumor Volume

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