Rate of Change of Functional Abilities in Frontotemporal Dementia

Mioshi, Eneida; Hodges, John R.

doi:10.1159/000255652

Cited by 67 publications

(83 citation statements)

References 55 publications

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“…The current findings are important as they corroborate previous studies [2,4,7,8,22,23], which have indicated higher behavioral disturbances and caregiver strain in bvFTD, with data originating from a developing nation. In our study, the most frequently reported symptoms in bvFTD were apathy (85%), irritability (65%), disinhibition (60%) and agitation/aggression (55%).…”

Section: Discussionsupporting

confidence: 91%

“…De Vugt et al [2] and Riedijk et al [4] found higher distress in caregivers of bvFTD patients using the NPI, whereas Mioshi and Hodges [7] reported similar results using the Perceived Stress Scale. In the current study, apathy generated the highest distress, followed by disinhibition, irritability and aggression, in agreement with de Vugt et al [2].…”

Section: Discussionmentioning

confidence: 99%

“…With the exception of apathy, such symptoms have been considered as part of a disruptive cluster of neuropsychiatric symptoms and, as such, they have been described as highly stressful by dementia caregivers [6,22,23]. Nevertheless, apathy has also been reported as highly stressful by family caregivers [7,24]. …”

Section: Discussionmentioning

confidence: 99%

“…In this latter study, bvFTD patients presented higher scores for apathy, disinhibition and eating disorders according to NPI scores. More recently, Mioshi and Hodges [7] and Mioshi et al [8] have suggested that burden is higher among caregivers of bvFTD patients; yet, this may be due to a constellation of factors, including dementia severity, relationship changes and caregivers' depression.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the aims of the present investigation were: (1) to compare caregiver burden and distress in bvFTD and AD and (2) to investigate the association between patients' cognitive, functional and behavioral disturbances and bvFTD and AD caregivers' burden and distress. New knowledge about these associations, especially originating from a developing nation, with a different cultural background and different access to services, may be crucial for the development of effective caregiver interventions that might be suitable across nations [7,10]. Based on previous studies, we hypothesized that bvFTD patients would present higher behavioral disturbances, that their caregivers would report higher levels of burden and distress and that functional and neuropsychiatric symptoms would be more robustly associated with caregiver strain in bvFTD than in AD.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Neuropsychiatric Symptoms, Caregiver Burden and Distress in Behavioral-Variant Frontotemporal Dementia and Alzheimer's Disease

Lima-Silva¹,

Bahia²,

Carvalho

et al. 2015

Dement Geriatr Cogn Disord

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Background/Aims: We aimed to compare caregiver burden and distress in behavioral-variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) and to investigate which factors contribute to caregivers' burden and distress. Methods: Fifty patients and their caregivers were invited to participate. Among the patients, 20 had a diagnosis of bvFTD and 30 had AD. Caregivers and patients were statistically equivalent for age, sex, education and dementia severity according to Clinical Dementia Rating. The protocol included the Short Zarit Burden Inventory, the Neuropsychiatric Inventory (NPI), Disability Assessment for Dementia (DAD), the Cornell Scale for Depression in Dementia (CSDD), Addenbrooke's Cognitive Examination-Revised, the Executive Interview with 25 Items, Direct Assessment of Functional Status and the Geriatric Anxiety Inventory (GAI). Results: In the NPI, caregivers of bvFTD patients reported a higher presence and severity of neuropsychiatric symptoms and caregiver distress compared to caregivers of AD patients. There was no significant difference in the perceived burden. In bvFTD, DAD and GAI scores were significantly correlated with burden, whereas in AD, burden was correlated with CSDD and NPI scores. Psychiatric symptoms were associated with distress in both groups. Conclusions: Caregivers of bvFTD patients experienced higher levels of distress than caregivers of AD patients. Patients' functional limitations were associated with burden of caregivers of bvFTD patients, whereas neuropsychiatric symptoms were associated with caregiver strain in both groups.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Neuropsychiatric Symptoms, Caregiver Burden and Distress in Behavioral-Variant Frontotemporal Dementia and Alzheimer's Disease

Lima-Silva¹,

Bahia²,

Carvalho

et al. 2015

Dement Geriatr Cogn Disord

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Frontotemporal Dementia Associated With theC9ORF72Mutation

et al. 2014

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IMPORTANCE While advances have been made in characterizing the C9ORF72 clinical phenotype, the hallmark features that discriminate between carriers and noncarriers remain unclear. OBJECTIVES To determine the frequency of the C9ORF72 mutation in a frontotemporal dementia (FTD) cohort and to define the clinical, neuropsychological, behavioral, and imaging features of C9ORF72 mutation carriers in comparison with noncarriers in a well-defined behavioral-variant (bv)-FTD cohort. DESIGN, SETTING, AND PARTICIPANTS A prospective cohort study of patients assessed during a 5-year period from January 1, 2008, to December 31, 2012, at an FTD specialist referral center (FRONTIER). A total of 114 consecutive patients with FTD, FTD-amyotrophic lateral sclerosis (ALS), and corticobasal syndrome were assessed at FRONTIER. Patients with bvFTD who carried the C9ORF72 mutation (n = 10) were compared with noncarriers (n = 19) and a healthy control group (n = 35). These were matched for age, sex, and education history. Blood sampling for gene analysis was performed after informed consent was obtained. MAIN OUTCOMES AND MEASURES Clinical, behavioral, cognitive, and neuropsychological deficits, cortical atrophy on a magnetic resonance imaging visual rating scale, and family history as quantified by the Goldman Scale. RESULTS In a cohort of 114 FTD cases, 14 patients expressed the C9ORF72 mutation, representing a frequency rate of 34% in bvFTD and 17% in FTD-ALS. Family histories of ALS (P = .001) and psychiatric disorders (P = .02) were significantly more common in mutation carriers. The C9ORF72 carriers were also more likely to experience psychotic symptoms (P = .03). The degree of brain atrophy was significantly less in the C9ORF72 cohort, and in many the progression was slow. Presenting features of C9ORF72 carriers were compared against International Consensus Diagnostic Criteria for bvFTD, and most cases failed to satisfy criteria for probable bvFTD. CONCLUSIONS AND RELEVANCE The C9ORF72 mutation appears to be a common cause of bvFTD. Many of the C9ORF72 carriers have a family history of ALS or psychiatric illness. Psychotic features emerged as the most discriminating clinical feature between mutation carriers and noncarriers. Progression is often slow and brain atrophy is less pronounced than in nonmutation cases of bvFTD. These findings have clinical relevance for both diagnosis and selection of patients for genetic testing.

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Functional decline in the aphasic variant of Alzheimer's disease

Moeller

Sridhar

Martersteck

et al. 2021

Alzheimer's & Dementia

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Introduction: Primary progressive aphasia (PPA) is a clinical dementia syndrome associated with frontotemporal lobar degeneration (FTLD) or Alzheimer's disease (AD).Impairment in activities of daily living is essential for dementia diagnosis, yet less is known about the neuropathologic impact on functional decline in PPA, especially over time.Methods: Activities of Daily Living Questionnaire (ADLQ) ratings were compared by suspected underlying pathology between 17 PPA Aβ+ and 11 PPA Aβparticipants at 6month intervals for 2 years using a linear mixed-effects model. A general linear model examined associations between functional decline and cortical thickness at baseline.

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Rate of Change of Functional Abilities in Frontotemporal Dementia

Cited by 67 publications

References 55 publications

Neuropsychiatric Symptoms, Caregiver Burden and Distress in Behavioral-Variant Frontotemporal Dementia and Alzheimer's Disease

Neuropsychiatric Symptoms, Caregiver Burden and Distress in Behavioral-Variant Frontotemporal Dementia and Alzheimer's Disease

Frontotemporal Dementia Associated With theC9ORF72Mutation

Functional decline in the aphasic variant of Alzheimer's disease

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