Neuropsychiatric Symptoms, Caregiver Burden and Distress in Behavioral-Variant Frontotemporal Dementia and Alzheimer's Disease

Lima-Silva, Thaís Bento; Bahia, Valéria Santoro; Carvalho, Viviane Amaral; Guimarães, Henrique Cerqueira; Caramelli, Paulo; Balthazar, Márcio Luiz Figueredo; Damasceno, Benito Pereira; Bottino, Cássio Machado de Campos; Brucki, Sônia Maria Dozzi; Nitrini, Ricardo; Yassuda, Mônica Sanches

doi:10.1159/000437351

Cited by 70 publications

(78 citation statements)

References 24 publications

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“…As the correct diagnosis is the cornerstone of patient's management, misdiagnosis should be avoided to prevent treatment delay. Furthermore, a correct diagnosis of bvFTD has direct implications for heritability, prognosis and patient management [34,35]. …”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of the Frontotemporal Dementia Consensus Criteria in the Late-Onset Frontal Lobe Syndrome

Vijverberg

Dols

Krudop

et al. 2016

Dement Geriatr Cogn Disord

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Background/Aims: We aimed to prospectively assess the diagnostic accuracy of the revised criteria for behavioural variant frontotemporal dementia (bvFTD) among subjects presenting with a frontal lobe syndrome in middle-late adulthood. Methods: Patients were included based on a predominant behavioural clinical presentation, a Frontal Behavioural Inventory (FBI) score of ≥11 and/or a Stereotypy Rating Inventory (SRI) score of ≥10. At baseline, the fulfilment of the international consensus criteria for behavioural variant FTD (FTDC) was systematically recorded. The 2-year follow-up consensus diagnosis was used as the gold standard to calculate sensitivity and specificity of the FTDC criteria for possible and probable bvFTD. Results: Two-year follow-up data were available for 116 patients (85%). Two-year follow-up consensus diagnoses consisted of probable/definite bvFTD (n = 27), other dementia (n = 30), psychiatric disorders (n = 46) and other neurological disorders (n = 13). Sensitivity for possible bvFTD was 85% (95% CI 70-95%) at a specificity of 27% (95% CI 19-37%). Sensitivity for probable bvFTD was 85% (95% CI 69-95%), whereas their specificity was 82% (95% CI 73-89%). Conclusions: We found a good diagnostic accuracy for FTDC probable bvFTD. However, the specificity for FTDC possible bvFTD was low. Our results reflect the symptomatic overlap between bvFTD, other neurological conditions and psychiatric disorders, and the relevance of adding neuroimaging to the diagnostic process.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of the Frontotemporal Dementia Consensus Criteria in the Late-Onset Frontal Lobe Syndrome

Vijverberg

Dols

Krudop

et al. 2016

Dement Geriatr Cogn Disord

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“…He believed in the power of rewards to increase the likelihood of a behavior and punishments to decrease the occurrence of a behavior. Behavioral therapists work on changing unwanted and destructive behaviors through behavior modification techniques such as positive or negative reinforcement [39,40] …”

Section: Behavior Therapymentioning

confidence: 99%

Development in diagnosis and treatment of Alzheimer’s disease

Kumar¹

2016

IOSRPHR

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ABSTRACT:-The decrease in hippocampal neurogenesis can lead to development of Alzheimer disease (AD), yet various hypothesis suggest that AD patient have increased neurogenesis in the region 1 of hippocampus proper (CA1 region). Ammon"s horn (the principle region of Alzheimer"s pathology) has been found to be involved in neuronal loss however the exact nature of neurogenesis is unknown. Insulin like growth factor 1 (IGF-1 are associated with an increased risk of developing AD) stimulates neurogenesis to produce major change in hippocampal plasticity and seems to be involved in Alzheimer"s pathology. Allopregnanolone, a neurosteroid, aids in continued neurogenesis in the brain. Levels of allopregnanolone in the brain decline in old age and Alzheimer"s disease Allopregnanolone acts by reversing neurogenesis impairment thus preventing cognitive deficitis of AD disease in various mouse models. Ephirin signaling pathway has been shown to regulate neurogenesis in the hippocampus and have been studied as potential target to treat some symptoms of AD. Molecule associated with the pathology of AD, including Apo lipoprotein (ApoE), presenilin genesPSI,PS2 and APP have also been found to impact adult neurogenesis in the hippocampus. Detection and diagnosis of AD is done by variety of neuro-psychatic and imaging techniques. Psychological, behavioral, cognitive, holistic and humanistic therapy approaches are used for its treatment.

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“…Measures of neuropsychiatric symptoms may be more clinically relevant [4]. As neurosyphilis can mimic any psychiatric disorder, routine screening of psychiatric patients for syphilis is recommended [5].…”

Section: Introductionmentioning

confidence: 99%

Neuropsychiatric Features of Neurosyphilis: Frequency, Relationship with the Severity of Cognitive Impairment and Comparison with Alzheimer Disease

Zhong

Shi

Hou

et al. 2017

Dement Geriatr Cogn Disord

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Background: The pattern of neuropsychiatric features of patients with neurosyphilis and the impact of the severity of cognitive impairment on neuropsychiatric syndromes are unknown. Objective: We aim to assess the neuropsychiatric features of patients with neurosyphilis, and compare the impact of the severity of cognitive impairment on the neuropsychiatric syndromes between neurosyphilis and Alzheimer disease (AD). Methods: Neuropsychiatric symptoms and the degree of cognitive impairment were assessed in a case-control study of 91 neurosyphilis, 162 AD, 157 mild cognitive impairment, and 139 normal controls by the Neuropsychiatric Inventory (NPI) scale and Clinical Dementia Rating scale, respectively. Factor analysis was performed on the 12 NPI items. Results: Factor analysis showed that patients with neurosyphilis showed more severe neuropsychiatric syndromes at the dementia stage than those neurosyphilis patients at the mild cognitive impairment stage, while neuropsychiatric manifestations were equally common among the different stages of dementia (all p < 0.05). Frontal lobe syndrome was more severe in patients with neurosyphilis than in patients with AD from the early mild cognitive impairment stage to the moderate dementia stage (all p < 0.01). Conclusions: Patients with neurosyphilis show different patterns of neuropsychiatric syndromes at the mild cognitive impairment and dementia stages, and differ from patients with AD.

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Neuropsychiatric Symptoms, Caregiver Burden and Distress in Behavioral-Variant Frontotemporal Dementia and Alzheimer's Disease

Cited by 70 publications

References 24 publications

Diagnostic Accuracy of the Frontotemporal Dementia Consensus Criteria in the Late-Onset Frontal Lobe Syndrome

Diagnostic Accuracy of the Frontotemporal Dementia Consensus Criteria in the Late-Onset Frontal Lobe Syndrome

Development in diagnosis and treatment of Alzheimer’s disease

Neuropsychiatric Features of Neurosyphilis: Frequency, Relationship with the Severity of Cognitive Impairment and Comparison with Alzheimer Disease

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