Raspberry-like small multicore gold nanostructures for efficient photothermal conversion in the first and second near-infrared windows

Sangnier, Anouchka Plan; Aufaure, Romain; Cheong, Soshan; Motte, Laurence; Palpant, Bruno; Tilley, Richard D.; Guénin, Erwann; Wilhelm, Claire; Lalatonne, Yoann

doi:10.1039/c8cc09476d

Cited by 20 publications

(19 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the America National Standards for Safe Use of Lasers, MPE for skin exposure to NIR-I laser (808 nm) is 0.33 W cm −2 , while that to NIR-II laser (1064 nm) is 1 W cm −2 (ANSI Z136.1-2007), allowing a wider applicability of NIR-II-responsive photothermal agents [4]. Nowadays, several materials including inorganic nanomaterials [5][6][7][8][9][10], small organic molecule-based nanoparticles [11][12][13] and semiconducting polymer nanoparticles [14][15][16][17][18][19][20] have been explored as therapeutic agents for efficient NIR-II photothermal tumor ablation in vitro and in vivo. Though an excellent antitumor effect has been achieved, the tumor depth profiles after NIR-II PTT are rarely systematically studied.…”

Section: Introductionmentioning

confidence: 99%

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Guo

Zhang

et al. 2020

Sci. China Mater.

View full text Add to dashboard Cite

Research on deep-tissue photothermal therapy (PTT) in the near-infrared II (NIR-II, 1000-1350 nm) region has bloomed in recent years, owing to higher maximum permissible exposure and deeper tissue penetration over that in the near-infrared I (NIR-I, 650-950 nm) region. However, more details need to be uncovered to facilitate a fundamental understanding of NIR-II PTT. Herein, a tumor-targeted therapeutic nanosystem based on NIR-responsive molybdenum oxide (MoO 2) nanoaggregates was fabricated. The photothermal conversion capabilities of MoO 2 in the NIR-I and II regions were investigated step by step, from a simple tissue phantom to a three-dimensional cellular system, and further to a tumor-bearing animal model. NIR-II laser exhibited a lower photothermal attenuation coefficient (0.541 at 1064 nm) in a tissue phantom compared with its counterpart (0.959 at 808 nm), which allows it to be more capable of deeptissue PTT in vitro and in vivo. Depth profile analysis elucidated a negative correlation between the microstructural collapse of tumor tissue and the penetration depth. Moreover, the depth-related tumor ablation was also studied by Raman fingerprint analysis, which demonstrated the major biochemical compositional disturbances in photothermal ablated tumor tissues, providing fundamental knowledge to NIR-II deeptissue photothermal therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Guo

Zhang

et al. 2020

Sci. China Mater.

View full text Add to dashboard Cite

show abstract

“…To modulate the plasmonic resonance to the NIR, anisotropic gold nanoparticles such as nanorods, nanostars, and nanoshells have been proposed and experimented for cancer thermotherapy 34–36. However photothermal agents within NIR‐II are still rare;37–39 among them, multicore gold nanoparticles were recently described as very effective NIR‐II nanoheaters 40,41…”

Section: Introductionmentioning

confidence: 99%

“…Gold nanorods with narrow plasmons at 680 and 808 nm were then chosen as state‐of‐the‐art photothermal gold nanoparticles 48. Finally, gold nanoraspberries were produced, of size small enough (25 nm range), with the advantage of covering both the first and second NIR windows 41. To assess the impact of cellular internalization on the nanoparticle thermal efficiency, both absorption spectra and heat generation were measured after internalization in cancer cells and compared with measurements in aqueous dispersion, under the same settings.…”

Section: Introductionmentioning

confidence: 99%

Endosomal Confinement of Gold Nanospheres, Nanorods, and Nanoraspberries Governs Their Photothermal Identity and Is Beneficial for Cancer Cell Therapy

et al. 2020

Self Cite

View full text Add to dashboard Cite

Gold nanoparticles can act as photothermal agents to generate local tumor heating and subsequent depletion upon laser exposure. Herein, photothermal heating of four gold nanoparticles and the resulting induced cancer cell death are systematically assessed, within extra‐ or intracellular localizations. Two state‐of‐the‐art gold nanorods are compared with small nanospheres (single‐core) and nanoraspberries (multicore). Heat generation is measured in water dispersion and in cancer cells, using lasers at wavelengths of 680, 808, and 1064 nm, covering the entire range used in photothermal therapy, defined as near infrared first (NIR‐I) and second (NIR‐II) windows, with NIR‐II offering more tissue penetration. When dispersed in water, gold nanospheres provide no significant heating, gold nanorods are efficient in NIR‐I, and only gold nanoraspberries are still heating in NIR‐II. However, in cells, due to endosomal confinement, all nanoparticles present an absorption red‐shift translating visible and NIR‐I absorbing nanoparticles into effective NIR‐I and NIR‐II nanoheaters, respectively. The gold nanorods then become competitive with the multicore nanoparticles (nanoraspberries) in NIR‐II. Similarly, once in cells, gold nanospheres can be envisaged for NIR‐I heating. Remarkably, nanoraspberries are efficient nanoheaters, whatever the laser applied, and the extra‐ versus intra‐cellular localization demonstrates treatment versatility.

show abstract

“…The phothothermal conversation efficiency (η) was then calculated from the heating curves, and found to be (23 ± 3)% (Figure S3 C,D). This value of η is high enough to justify the use of such particles for photothermal therapy 61.…”

Section: Resultsmentioning

confidence: 99%

TRAIL acts synergistically with iron oxide nanocluster-mediated magneto- and photothermia

Belkahla¹,

Mazarío²,

Sangnier³

et al. 2019

Theranostics

Self Cite

View full text Add to dashboard Cite

Targeting TRAIL (Tumor necrosis factor (TNF)-Related Apoptosis-Inducing Ligand) receptors for cancer therapy remains challenging due to tumor cell resistance and poor preparations of TRAIL or its derivatives. Herein, to optimize its therapeutic use, TRAIL was grafted onto iron oxide nanoclusters (NCs) with the aim of increasing its pro-apoptotic potential through nanoparticle-mediated magnetic hyperthermia (MHT) or photothermia (PT).Methods: The nanovector, NC@TRAIL, was characterized in terms of size, grafting efficiency, and potential for MHT and PT. The therapeutic function was assessed on a TRAIL-resistant breast cancer cell line, MDA-MB-231, wild type (WT) or TRAIL-receptor-deficient (DKO), by combining complementary methylene blue assay and flow cytometry detection of apoptosis and necrosis.Results: Combined with MHT or PT under conditions of “moderate hyperthermia” at low concentrations, NC@TRAIL acts synergistically with the TRAIL receptor to increase the cell death rate beyond what can be explained by the mere global elevation of temperature. In contrast, all results are consistent with the idea that there are hotspots, close to the nanovector and, therefore, to the membrane receptor, which cause disruption of the cell membrane. Furthermore, nanovectors targeting other membrane receptors, unrelated to the TNF superfamily, were also found to cause tumor cell damage upon PT. Indeed, functionalization of NCs by transferrin (NC@Tf) or human serum albumin (NC@HSA) induces tumor cell killing when combined with PT, albeit less efficiently than NC@TRAIL.Conclusions: Given that magnetic nanoparticles can easily be functionalized with molecules or proteins recognizing membrane receptors, these results should pave the way to original remote-controlled antitumoral targeted thermal therapies.

show abstract

Raspberry-like small multicore gold nanostructures for efficient photothermal conversion in the first and second near-infrared windows

Abstract: Gold nanoraspberries were synthesized by a seed-mediated synthesis with polyethylene glycol-functionalized bisphosphonates.

Cited by 20 publications

References 42 publications

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Endosomal Confinement of Gold Nanospheres, Nanorods, and Nanoraspberries Governs Their Photothermal Identity and Is Beneficial for Cancer Cell Therapy

TRAIL acts synergistically with iron oxide nanocluster-mediated magneto- and photothermia

Contact Info

Product

Resources

About