Abstract:The human androgen receptor (AR) gene promoter lies in a GC-rich region containing two principal sites of transcription initiation and a putative Sp1 protein-binding site, without typical "TATA" and "CAAT" boxes. It has been suggested that mutations within the 5'untranslated region (5'UTR) may contribute to the development of prostate cancer by changing the rates of gene transcription and/or translation. In order to investigate this question, the aim of the present study was to search for the presence of mutat… Show more
“…The third alteration ,which was found in the one healthy man out of 100 blood donors, was 25delT in a conserved region of 5 0 -UTR. In the same study no germ-line alterations were found among 92 prostate cancer patients [25]. In addition, one somatic change in 3 0 -UTR of a prostate cancer specimen has been reported [26].…”
Section: Introductionmentioning
confidence: 78%
“…Two single cases of germ-line alterations have been identified in the 5 0 -UTR and one in the promoter region, two of these in prostate cancer patients [24], and one in a healthy male blood donor [25]. The alterations that were found in one prostate cancer patient were G-10T within the ARTIS I and C203A within a GC rich region of the 5 0 -UTR [24].…”
Recurrent mutations in the promoter or UTRs of AR seem to be rare, and thus not likely mechanisms for the increased expression of the gene in the androgen ablation-resistant prostate cancer.
“…The third alteration ,which was found in the one healthy man out of 100 blood donors, was 25delT in a conserved region of 5 0 -UTR. In the same study no germ-line alterations were found among 92 prostate cancer patients [25]. In addition, one somatic change in 3 0 -UTR of a prostate cancer specimen has been reported [26].…”
Section: Introductionmentioning
confidence: 78%
“…Two single cases of germ-line alterations have been identified in the 5 0 -UTR and one in the promoter region, two of these in prostate cancer patients [24], and one in a healthy male blood donor [25]. The alterations that were found in one prostate cancer patient were G-10T within the ARTIS I and C203A within a GC rich region of the 5 0 -UTR [24].…”
Recurrent mutations in the promoter or UTRs of AR seem to be rare, and thus not likely mechanisms for the increased expression of the gene in the androgen ablation-resistant prostate cancer.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.