Rare pulmonary primitive neuroectodermal tumor metastasizing to the right atrium: a case report

Mao, Liwei; Wang, Hongmei; Xie, Guoming; Zhang, Na; Liao, Gaoliang

doi:10.1007/s12032-012-0200-5

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…The most common treatment interventions in metastatic PNET were chemotherapy plan only (n = 6) [26][27][28][29][30][31] and surgical plan (tumor resection) with chemotherapy (n = 5). [32][33][34][35][36] One patient had only tumor resection, 37 one patient underwent both chemotherapy and radiotherapy, 38 and one patient was without any intervention.…”

Section: Metastatic Pnetmentioning

confidence: 99%

Primary and metastatic primitive neuroectodermal tumor of the heart: A systematic review

Hajsadeghi

Iranpour

Amouei

et al. 2022

Asian Cardiovasc Thorac Ann

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Objective Primary and metastatic primitive neuroectodermal tumors of the pericardium are uncommon. Two cases are presented and discussed. Methods The cases of a 17- and 38-year-old male patients with neuroectodermal tumors of the pericardium are presented. In addition, a systematic review was performed according to the Preferred Reporting Items and checklist for Systematic reviews and Meta-Analyses (PRISMA). All selected articles’ quality assessment was done using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports. Results The systematic review yielded 29 patients with primary or metastatic PNET. Two patients underwent cardiac transplantation. It seems that unlike considering total resection in other organs, pericardiectomy in PNET patients with pericardial origin may lead to further invasion of the lesions, and it is not recommended. The average disease-free follow-up was 10 months. The combination of neoadjuvant and adjuvant chemotherapy along with surgery and radiotherapy offered the best disease-free outcomes. Conclusion Neuroectodermal heart tumors are rare, aggressive tumors requiring chemotherapy and radiotherapy in association with tumor resection surgery to have the best disease-free duration.

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Section: Metastatic Pnetmentioning

confidence: 99%

Primary and metastatic primitive neuroectodermal tumor of the heart: A systematic review

Hajsadeghi

Iranpour

Amouei

et al. 2022

Asian Cardiovasc Thorac Ann

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“…To date, the 18 F-FDG PET/CT imaging features of pPNETs have only been published in case reports (18-25) (see Table 2 for a summary). A soft tissue mass with high uptake of 18 F-FDG and the SUVmax ranging from 4.36 to 17.2 is observed in most pPNET lesions (18)(19)(20)(21)(22)(23)(24). Significantly high 18 F-FDG uptake by pPNET lesions was observed in all 23 patients reported in this study.…”

Section: F-fdg Pet/ct Characteristics Of Ppnet Primary and Metastatic Lesionsmentioning

confidence: 99%

“…Additionally, 18 F-FDG PET/CT can simultaneously display the metabolic rates of primary and metastatic pPNET lesions and play an important role in the efficacy evaluation and follow-up (20,21). In this study, 5 patients with pPNETs underwent 18 F-FDG PET/CT for systemic examination after surgery and/or chemoradiotherapy (between 3 months and 2 years).…”

Section: Advantages Of 18 F-fdg Pet/ct Vs Ct or Mrimentioning

confidence: 99%

“…In recent years, 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has shown unique advantages in the diagnosis, differential diagnosis, staging, and prognosis evaluation of malignant tumors and has been considered an alternative that can compensate for the limitations of CT and MRI (16,17). However, to the best of our knowledge, all 18 F-FDG PET/CT imaging studies of pPNET in the current literature are described in case reports (18)(19)(20)(21)(22)(23)(24)(25), which represent a lower level of evidence.…”

Section: Introductionmentioning

confidence: 97%

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A novel insight in the diagnosis of peripheral primitive neuroectodermal tumors: a retrospective analysis of 23 patients

Li¹,

Li²,

Zhao³

et al. 2018

Transl. Cancer Res

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Background: Peripheral primitive neuroectodermal tumors (pPNETs) are rare, small, round cell tumors with high malignancy and invasiveness and a poor prognosis. 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is important in the diagnosis of pPNETs, but the current literature on PET/CT imaging of pPNETs is limited to case reports with low-quality evidence.Methods: This study retrospectively analyzed the 18 F-FDG PET/CT images of 23 patients with pPNETs.Clinical information and 18 F-FDG PET/CT data were collected to analyze the PET/CT features of primary and metastatic lesions and to explore the pathological morphology, metabolism, and distribution patterns of pPNETs.Results: Of the 23 pPNET patients, 18 were male, with an average age of 26.22 years (range, 12 to 41 years). The location of the primary lesion was bone in 16 patients and non-skeletal (muscle, lung, liver, kidney, testis and mediastinum) in 7. 18 F-FDG PET/CT of all patients showed a soft tissue mass with a significantly intense 18 F-FDG uptake. The maximum diameter of the lesion was 7.64±2.38 cm, and the maximum standard uptake value (SUVmax) was 11.27±3.80. Primary pPNETs with ill-defined borders, heterogeneous density and invasion into the adjacent tissues were observed in 73.9% (17/23) of the patients.Necrosis or cystic changes were found in 52.17% of the lesions. No calcification was noted in any lesions.Metastases were observed in 43.5% (10/23) of the patients, including hematogenous metastases to the bone (7 patients), bilateral lungs (4 patients), liver (3 patients), vascular tumor thrombus (2 patients), and metastasis to the pericardium (1 patient); 13.0% (3/23) of patients had lymph node metastases. The rate of multiple metastases was higher in patients with primary non-skeletal pPNET than in those with primary bone pPNET [6/7 (85.7%) vs. 4/16 (25%)].Conclusions: Both primary and metastatic pPNETs lesions showed high uptake of 18 F-FDG on 18 F-FDG PET/CT imaging, which has high detection sensitivity. 18 F-FDG PET/CT is of great value for the diagnosis, differential diagnosis, clinical decision-making, evaluation of efficacy, and recurrence assessment of pPNETs.

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PET/TC con 18 F-FDG en metástasis cardíaca en un paciente con antecedente de tumor neuroectodérmico maligno de la pared torácica (tumor de Askin): caso clínico y revisión de la literatura

Marroquín

Hernández

Pilkington

et al. 2018

Revista Española de Medicina Nuclear e Imagen Molecular

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Rare pulmonary primitive neuroectodermal tumor metastasizing to the right atrium: a case report

Cited by 6 publications

References 7 publications

Primary and metastatic primitive neuroectodermal tumor of the heart: A systematic review

Primary and metastatic primitive neuroectodermal tumor of the heart: A systematic review

A novel insight in the diagnosis of peripheral primitive neuroectodermal tumors: a retrospective analysis of 23 patients

PET/TC con 18 F-FDG en metástasis cardíaca en un paciente con antecedente de tumor neuroectodérmico maligno de la pared torácica (tumor de Askin): caso clínico y revisión de la literatura

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