Rare Presentation of Unicentric Castleman's Disease in the Parotid Gland

Castleman Disease of the Parotid Gland: A Case Report

“…6 In a related manner, CD has been closely associated with interleukin (IL) 6 and tumor necrosis factor a. 3 Clinical manifestations of CD have been classified into unicentric and multicentric forms. The unicentric form (UCD) is typically found in young adults and manifests as an asymptomatic painless mass.…”

“…In this report, we have reviewed the literature regarding patients with parotid gland involvement in CD and analyzed the clinical characteristics of their cases (Table 1). 3,4,7,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] In our review,…”

“…33 There are many options for treatment of MCD but no official guidelines thus far. Therapies for MCD include chemotherapy, immunosuppressive therapy, radiotherapy, and corticosteroid therapy 3 ; chemotherapy combined with steroid therapy is the most common treatment approach. In recent years, overproduction of IL-6 has been shown to play an important role in the pathogenesis of MCD, although the specific mechanism is not well understood.…”

“…However, the parotid gland is rarely affected. 3 On the basis of histologic assessment, CD is classified into 3 subtypes: hyaline vascular, plasma cell, and mixed. On the basis of clinical assessment, CD is classified into unicentric and multicentric forms.…”

Castleman Disease of the Parotid Gland: A Report of a Case

“…Of those, the most supported theory is excessive lymphoproliferation due to chronic stimulation by a virus or chronic inflammation. It has been proven in the literature that there is a strong association between CD and viral infections: EBV, HIV, and HHV-8 [ 7 ]. Another strong theory proposes the significance of the interaction between interleukin 6 and tumor necrosis factor alpha and the systemic presentation of multicentric CD [ 7 ].…”