Castleman Disease of the Parotid Gland: A Case Report

Abstract

Castleman disease is a rare lymphoproliferative disorder characterized by the formation of painless hyperplastic lymph nodes. It can affect any lymph nodes of the body but rarely affects the salivary gland. We describe a patient with unicentric Castleman disease presenting as a parotid tumor and discuss the diagnosis and treatment of Castleman disease. A 39-year-old man had a painless lump on the right side of his face for 1 year. A computed tomography scan showed a well-defined, homogeneous mass in the right parotid gland. The patient underwent a right-sided superficial parotidectomy with preservation of the facial nerve. Histopathologic analysis of the excisional biopsy specimen confirmed the diagnosis of Castleman disease. No further treatment was administered, and the patient recovered well; no recurrence was present at the 1-year follow-up. Castleman disease is a lymphoproliferative disease that rarely affects the parotid gland. Histopathologic examination is regarded as the gold standard for diagnosis of Castleman disease. The current treatment for patients with unicentric Castleman disease is surgical resection. For patients with multicentric Castleman disease, more complex therapies are required.

Benign lymphoproliferative disorders in the immunosuppressed patient: an update

“…Two forms of the disease are recognised, unicentric and multicentric (MCD), with the latter often being associated with immunosuppression and HHV8 infection. Microscopically, two subtypes are identified: the more common hyaline vascular variant and the plasma cell variant 22–24 . The plasma cell variant may be further subdivided to include HHV8‐positive and HHV8‐negative cases.…”

“…Lymphadenopathy is the main clinical finding, with B symptoms (fever, night sweats and weight loss) reported in over 95% of patients. Other common clinical presentations include splenomegaly and hepatomegaly 22,23 …”

“…These individuals may subsequently develop lymphomas. Whereas the unicentric type is treated surgically, MCD often requires combination chemotherapy and steroids, with relative success; however, overall prognosis still remains poor 22–24 …”

Retroperitoneal Unicentric Castleman's disease, a case report

“…So, certain diagnosis is essential to avoid unnecessary treatment. The diagnosis of CD is challengeable for clinicians and pathology evaluation is requirement to affordable treatment [ 6 ]. The clinical symptoms and signs are various and the diagnosis is problematic and optimal managing is still indefinite.…”

Hypermetabolic Unicentric Castleman Disease of Kidney on FDG PET/CT

“…Rarely, unicentric Castleman disease presents in unusual sites, including the lung, pancreas, liver, adrenal, orbits, nasopharynx, spleen, parotid gland, and small bowel. [2][3][4][5][6][7][8][9][10] It has no specific clinical or radiologic features. Histologic examination is the key to a correct diagnosis.…”