Rare localization of extrarenal nephroblastoma in 1-month-old female infant

Armanda, Višnja; Čulić, Srđana; Pogorelić, Zenon; Kuljiš, Dubravka; Budimir, Dražen; Kuzmić-Prusac, Ivana

doi:10.1016/j.jpurol.2012.03.005

Cited by 18 publications

(11 citation statements)

References 10 publications

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“…Extrarenal nephroblastoma is an exceptionally rare tumor. 1 To our knowledge, this case is the first reported case of extrarenal nephroblastoma metastasizing to the CNS. The patient is living, at the time of writing, and has had long survival of 319.9 months (26.6 years) after brain metastasis and 347.9 months (29.0 years) after diagnosis of primary malignancy at age 2.1 years.…”

Section: Discussionmentioning

confidence: 70%

The pathological spectrum of solid CNS metastases in the pediatric population

Wiens

Hattab²

2014

PED

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Object Collectively, metastatic tumors are the most common malignancy encountered in the adult central nervous system (CNS), arising most often from lung, breast, skin, and gastrointestinal tract carcinomas. Limited information is available in the literature regarding solid nonhematopoietic CNS metastases in children. The authors carried out a retrospective study of pediatric metastatic neoplasms to the CNS treated in a 30-year period to characterize their frequency, common histological subtypes, and sites of origin. Methods The archival pathology files were searched (1981–2011) for metastatic tumors to the CNS in patients 21 years of age and younger. Pathology material was reviewed, tumors were classified by site of origin and histological subtype, and survival was evaluated. Results The authors identified 26 patients with solid nonhematopoietic CNS metastases out of 1135 pediatric CNS tumors diagnosed from 1981 to 2011. Patients ranged in age from 1.5 to 20.3 years and were equally divided between sexes. Most CNS metastases were supratentorial (85%) and solitary (65%). The mean interval from primary malignant diagnosis to CNS metastasis was 27 months. Sites of origin included kidney/adrenal, bone/soft tissue, gonads, head and neck, lung, and liver. Mean survival after CNS involvement was 36.6 months. Overall 1-year and 5-year survival rates were 52% and 16%, respectively. Conclusions In neuropathology practice, nonhematopoietic pediatric CNS metastases are far less common than are nonhematopoietic adult CNS metastases, accounting for approximately 2% of all pediatric CNS tumors. The most common tumors to exhibit CNS metastasis are of kidney/adrenal origin, followed by those from bone/soft tissue. As expected, prognosis is dismal, despite aggressive therapy.

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Section: Discussionmentioning

confidence: 70%

The pathological spectrum of solid CNS metastases in the pediatric population

Wiens

Hattab²

2014

PED

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“…Ameliyat öncesi tanı koyabilecek karakteristik görüntüleme yöntemi ya da tetkik yoktur (3,7) . Tümör tanısı genellikle kitlenin rezeksiyonundan sonra histopatolojik değerlendirmede konulur (2,13) .…”

Section: Discussionunclassified

“…Wilms tümörünün morfolojik bulgularını içeren tümör lezyonları böbrek dışında; retroperitoneal, lumbar-sakrokoksigeal bölge, testis, vajen, over, mesane, uterus, inguinal kanal, prostat, kolon, adrenal bez, cilt, göğüs duvarı ve mediastende yer aldığı az sayıda olguda gösterilmiştir (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) . Teratoid Wilms' klasik nefroblastomanın %50'sinden fazlasının heterolog elementler (yağ dokusu, glanduler doku, glial hücreler, kas hücreleri, kıkırdak ya da kemik dokusu) tarafından oluşturulduğu Variend ve ark.…”

Section: Introductionunclassified

“…(11) tarafından 1984 yılında tanımlanan bir tipidir. Bazı teratomların yoğun nefroblastik komponent içermesi durumunda teratoid Wilms tümöründen söz edilir ve tüm olguların %0,5-1'ini oluşturmaktadır (1,(3)(4)(5) . Teratoid Wilms tümörü lokal invazyon veya uzak metastaz özelliği olmayan tümör olarak bilinir (1) , ancak birçok olguda cerrahi sonrasında kemoterapi ya da radyoterapi gerekmektedir (3,7,8,13) .…”

Section: Introductionunclassified

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A rare tumour of childhood: Extrarenal retroperitoneal teratoid Wilms’

Bahadır¹,

Taşkınlar²,

Karabulut³

et al. 2016

TCCD

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“…Extrarenal Wilm's tumor (ERWT) is an extremely rare entity with an estimated occurrence of 0.5-1% of all Wilm's tumor cases [1]. It occurs mostly in early childhood; however cases in adults have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Extra-Renal Wilm’s Tumor In A 3 Years Old Boy-A Case Report

Khalid¹

2017

JCPCR

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Wilm's Tumor, also known as nephroblastoma is mainly a malignant tumor of the kidneys. Extrarenal Wilm's is a rare entity and only few case reports are available in paediatric literature. We report the case of a 3 years old Pakistani boy who presented with abdominal mass in right upper and lower quadrant associated with pain. Abdominal tomography revealed a huge retroperitoneal mass compressing the right kidney & liver. Trucut biopsy of the mass revealed WT1 positive Wilm's tumor. He is currently on postoperative chemotherapy and is doing well.

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Rare localization of extrarenal nephroblastoma in 1-month-old female infant

Cited by 18 publications

References 10 publications

The pathological spectrum of solid CNS metastases in the pediatric population

The pathological spectrum of solid CNS metastases in the pediatric population

A rare tumour of childhood: Extrarenal retroperitoneal teratoid Wilms’

Extra-Renal Wilm’s Tumor In A 3 Years Old Boy-A Case Report

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