Rare dimeric guaianes from Xylopia vielana and their multidrug resistance reversal activity

New Guaiane-Type Sesquiterpenoids Biscogniauxiaols A–G with Anti-Fungal and Anti-Inflammatory Activities from the Endophytic Fungus Biscogniauxia Petrensis

“…According to literature reports, guaiane-type sesquiterpenoids had anticancer and MDR reversal activities [30,31]. Thus, the anti-cancer and reversal activities of compounds 1-7 in the cisplatin sensitive A549 cells and resistant A549/DDP cells were evaluated in vitro, respectively.…”

“…However, they had weak reversal activities to the cisplatin resistant A549/DDP cells at concentrations of 50 µg/mL and 100 µg/mL compared to the control group DDP (Figures 7 and 8). According to literature reports, guaiane-type sesquiterpenoids had anticancer and MDR reversal activities [30,31]. Thus, the anti-cancer and reversal activities of compounds 1-7 in the cisplatin sensitive A549 cells and resistant A549/DDP cells were evaluated in vitro, respectively.…”

Exploring Diversity through Dimerization in Natural Products by a Rational Tandem Mass-Based Molecular Network Strategy

“…Cycloaddition of o -QM itself or between o -QM and the isochromene isomer at different sites can result in a wide variety of dimeric aromatic polyketides . Similarly, in sorbicillinol, the tautomerism of enol-keto and diene/dienophile bifunctionality are essential for the synthesis of Diels–Alder-type dimers of bisorbicillinol, bisorbibutenolide, and bisorbicillinolide; additionally, reactive allylic alcohol within sorbicillinol facilitates the formation of Michael-type dimers of trichodimerol, bisvertinol, and bisvertinolone. , In addition, a similar pattern of isomerization and/or diene/dienophile bifunctionality is also present in the cases of epoxycyclohexenone aldehyde , and guaiane monomer , (Figure S1).…”

Structure-Based Molecular Networking for the Target Discovery of Oxahomoaporphine and 8-Oxohomoaporphine Alkaloids from Duguetia surinamensis

“…1 Many of them, such as Annona cherimola (cherimoya), A. squamosa (sugarapple), A. montana (mountain soursop), A. mucosa (wild sugarapple), and A. muricata (soursop), have economic importance. 2 In addition, several other genera, including Bocageopsis, 3 Duguetia, 4 Onychopetalum, 5 Unonopsis, 6 Uvaria, 7 and Xylopia, 8 are of interest due to the presence of biologically active compounds. Among these genera, Duguetia comprises 94 species, with 66 of them occurring in Brazilian Amazonia and Cerrado ecosystems.…”