In addition to seven known alkaloids
(2, 6–11) and 1,2,4-trimethoxybenzene
(1), three isoquinoline-derived alkaloids (3–5), namely, duguetinine (3), a
compound based
on an unprecedented oxahomoaporphine scaffold, and two new 8-oxohomoaporphine
alkaloids, duguesuramine (4) and 11-methoxyduguesuramine
(5), and a new asarone-derived phenylpropanoid (10) were isolated from the bark of Duguetia surinamensis. The isolation workflow was guided by HPLC-HRESIMS/MS and molecular
networking-based analyses. Twenty-four known alkaloids were dereplicated
from the D. surinamensis alkaloid-rich fraction network
and were assigned by manual MS/MS interpretation. Their cytotoxic
potential was evaluated.
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