We investigate the possibility that scalar leptoquarks generate consequential effects on the flavor-changing neutral-current decays of charmed hadrons into final states with missing energy "Image missing" carried away by either standard model or sterile neutrinos. We focus on scenarios involving the R2, $$ {\tilde{R}}_2 $$
R
˜
2
, and $$ {\overline{S}}_1 $$
S
¯
1
leptoquarks and take into account various pertinent constraints, learning that meson-mixing ones and those inferred from collider searches can be of significance. We find in particular that the branching fractions of charmed meson decays D →"Image missing", M = π, ρ, and Ds→"Image missing" and singly charmed baryon decays $$ {\Lambda}_c^{+} $$
Λ
c
+
→"Image missing" and Ξc→"Image missing" are presently allowed to attain the 10−7-10−6 levels if induced by R2 and that the impact of $$ {\tilde{R}}_2 $$
R
˜
2
is comparatively much less. In contrast, the contributions of $$ {\overline{S}}_1 $$
S
¯
1
, which couples to right-handed up-type quarks and the sterile neutrinos, could lead to branching fractions as high as order 10−3. This suggests that these charmed hadron decays might be within reach of the BESIII and Belle II experiments or future super charm-tau factories and could serve as potentially promising probes of leptoquark interactions with sterile neutrinos.